Elagolix Sodium and its Impurities
Elagolix Sodium is used in the treatment of pain associated with endometriosis in women. It is sold under the brand name Orilissa.Reference standards of Elagolix Sodium API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

![3-[2(R)-amino-2-phenylethyl]-5-(2-fluoro-3-methoxy PA 05 1481000](https://www.pharmaffiliates.com/pimages/PA051481000.jpg)
3-[2(R)-amino-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4(1H,3H)-dione
3-[2(R)-amino-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4(1H,3H)-dione
Catalogue No.:PA 05 1481000
CAS :
830346-50-4
Molecular Formula : C28H24F5N3O3
Molecular Weight : 545.51


Methyl (R)-4-((2-(5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)amino)butanoate
Methyl (R)-4-((2-(5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)amino)butanoate
Catalogue No.:PA 05 1481001
CAS :
1092070-97-7
Molecular Formula : C33H32F5N3O5
Molecular Weight : 645.63


Ethyl (R)-4-((2-(5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)amino)butanoate hemi(4,4'-methylenebis(3-hydroxy-2-naphthoate))
Ethyl (R)-4-((2-(5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)amino)butanoate hemi(4,4'-methylenebis(3-hydroxy-2-naphthoate))
Catalogue No.:PA 05 1481002
CAS :
NA
Molecular Formula : C91H84F10N6O16
Molecular Weight : 1707.68


(R)-5-(2-Fluoro-3-methoxyphenyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-3-(2-(methylamino)-2-phenylethyl)pyrimidine-2,4(1H,3H)-dione
(R)-5-(2-Fluoro-3-methoxyphenyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-3-(2-(methylamino)-2-phenylethyl)pyrimidine-2,4(1H,3H)-dione
Catalogue No.:PA 05 1481003
CAS :
1062642-62-9
Molecular Formula : C29H26F5N3O3
Molecular Weight : 559.54


(R)-5-(2-Fluoro-3-methoxyphenyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-3-(2-(2-oxopyrrolidin-1-yl)-2-phenylethyl)pyrimidine-2,4(1H,3H)-dione
(R)-5-(2-Fluoro-3-methoxyphenyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-3-(2-(2-oxopyrrolidin-1-yl)-2-phenylethyl)pyrimidine-2,4(1H,3H)-dione
Catalogue No.:PA 05 1481004
CAS :
2248628-93-3
Molecular Formula : C32H28F5N3O4
Molecular Weight : 613.59


(R)-4,4'-((2-(5-(2-Fluoro-3-methoxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)azanediyl)dibutyric acid
(R)-4,4'-((2-(5-(2-Fluoro-3-methoxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)azanediyl)dibutyric acid
Catalogue No.:PA 05 1481005
CAS :
2409132-60-9
Molecular Formula : C36H36F5N3O7
Molecular Weight : 717.69


(R)-4-((2-(5-(2-Fluoro-3-hydroxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)amino)butanoic acid
(R)-4-((2-(5-(2-Fluoro-3-hydroxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)amino)butanoic acid
Catalogue No.:PA 05 1481006
CAS :
832720-51-1
Molecular Formula : C31H28F5N3O5
Molecular Weight : 617.57


Ethyl (R)-4-((2-(5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)amino)butanoate
Ethyl (R)-4-((2-(5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)amino)butanoate
Catalogue No.:PA 05 1481007
CAS :
832720-84-0
Molecular Formula : C34H34F5N3O5
Molecular Weight : 659.65


sodium (S)-4-((2-(5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)amino)butanoate
sodium (S)-4-((2-(5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)amino)butanoate
Catalogue No.:PA 05 1481008
CAS :
2756307-49-8
Molecular Formula : C32H29F5N3NaO5
Molecular Weight : 653.58


5-(2-Fluoro-3-methoxyphenyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione
5-(2-Fluoro-3-methoxyphenyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione
Catalogue No.:PA 05 1481009
CAS :
1150560-59-0
Molecular Formula : C20H15F5N2O3
Molecular Weight : 426.34


tert-Butyl (R)-(2-(5-bromo-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)carbamate
tert-Butyl (R)-(2-(5-bromo-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)carbamate
Catalogue No.:PA 05 1481013
CAS :
830346-49-1
Molecular Formula : C26H26BrF4N3O4
Molecular Weight : 600.41


(R)-4-((2-(4-(2,2-Dimethyl-4-oxopentyl)-5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)amino)butanoic Acid
(R)-4-((2-(4-(2,2-Dimethyl-4-oxopentyl)-5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)amino)butanoic Acid
Catalogue No.:PA 05 1481014
CAS :
2409132-64-3
Molecular Formula : C38H40F5N3O6
Molecular Weight : 729.75


(R)-4-((2-(5-Bromo-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)(nitroso)amino)butanoic Acid
(R)-4-((2-(5-Bromo-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)(nitroso)amino)butanoic Acid
Catalogue No.:PA 05 1481016
CAS :
NA
Molecular Formula : C25H23BrF4N4O5
Molecular Weight : 615.38


(R)-4-((2-(3-(2-Fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)amino)butanoic Acid
(R)-4-((2-(3-(2-Fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)amino)butanoic Acid
Catalogue No.:PA 05 1481017
CAS :
NA
Molecular Formula : C25H25F4N3O4
Molecular Weight : 507.49


(R)-4-((2-(5-(3-Ethoxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)amino)butanoic Acid
(R)-4-((2-(5-(3-Ethoxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)amino)butanoic Acid
Catalogue No.:PA 05 1481021
CAS :
832720-49-7
Molecular Formula : C33H33F4N3O5
Molecular Weight : 627.64


4-[[(1R)-2-[5-(2-Fluoro-3-methoxyphenyl)-3,6-dihydro-4-methyl-2,6-dioxo-3-[[2-(trifluoromethyl)phenyl]methyl]-1(2H)-pyrimidinyl]-1-phenylethyl]amino]butanoic Acid
4-[[(1R)-2-[5-(2-Fluoro-3-methoxyphenyl)-3,6-dihydro-4-methyl-2,6-dioxo-3-[[2-(trifluoromethyl)phenyl]methyl]-1(2H)-pyrimidinyl]-1-phenylethyl]amino]butanoic Acid
Catalogue No.:PA 05 1481026
CAS :
2375499-61-7
Molecular Formula : C32H31F4N3O5
Molecular Weight : 613.61


Sodium (R)-4,4'-((2-(5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)azanediyl)dibutyrate
Sodium (R)-4,4'-((2-(5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)azanediyl)dibutyrate
Catalogue No.:PA 05 1481028
CAS :
NA
Molecular Formula : C36H34F5N3Na2O7
Molecular Weight : 761.65


(R)-4-((2-(3-(2-Fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)(nitroso)amino)butanoic Acid
(R)-4-((2-(3-(2-Fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)(nitroso)amino)butanoic Acid
Catalogue No.:PA 05 1481029
CAS :
NA
Molecular Formula : C25H24F4N4O5
Molecular Weight : 536.48


(R)-4-((2-(5-(2-Fluoro-3-hydroxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)(nitroso)amino)butanoic Acid
(R)-4-((2-(5-(2-Fluoro-3-hydroxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)(nitroso)amino)butanoic Acid
Catalogue No.:PA 05 1481030
CAS :
NA
Molecular Formula : C31H27F5N4O6
Molecular Weight : 646.57


(R)-5-(2-fluoro-3-methoxyphenyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-(hydroxyamino)-2-phenylethyl)-6-methylpyrimidine-2,4(1H,3H)-dione
(R)-5-(2-fluoro-3-methoxyphenyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-(hydroxyamino)-2-phenylethyl)-6-methylpyrimidine-2,4(1H,3H)-dione
Catalogue No.:PA 05 1481031
CAS :
2486454-64-0
Molecular Formula : C28H24F5N3O4
Molecular Weight : 561.51