eltrombopag and its Impurities
Eltrombopag is used to treat low blood platelet counts in adults with chronic immune thrombocytopenia when certain other medicines, or surgery to remove the spleen, have not worked well enough. It has been recently approved for the treatment of thrombocytopenia in patients with chronic hepatitis C to allow them to initiate and maintain interferon-based therapy.. Reference standards of Eltrombopag API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below
 
	
			                                   
																				(E)-5'-Chloro-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)-1-hydroxyhydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic Acid
(E)-5'-Chloro-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)-1-hydroxyhydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic Acid
- Catalogue No.:PA 32 22540 
- CAS : - NA
- Molecular Formula : C25H21ClN4O5 
- Molecular Weight : 492.91 
 
	
			                                   
																				(E)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-methoxy-[1,1'-biphenyl]-3-carboxylic Acid
(E)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-methoxy-[1,1'-biphenyl]-3-carboxylic Acid
- Catalogue No.:PA 32 22560 
- CAS : - NA
- Molecular Formula : C26H24N4O4 
- Molecular Weight : 456.49 
 
	
			                                   
																				(Z)-5'-Chloro-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic Acid
(Z)-5'-Chloro-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic Acid
- Catalogue No.:PA 32 22570 
- CAS : - NA
- Molecular Formula : C25H21ClN4O4 
- Molecular Weight : 476.91 
 
	
			                                   
																				(Z)-2'-(Benzyloxy)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-[1,1'-biphenyl]-3-carboxylic Acid
(Z)-2'-(Benzyloxy)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-[1,1'-biphenyl]-3-carboxylic Acid
- Catalogue No.:PA 32 22580 
- CAS : - NA
- Molecular Formula : C32H28N4O4 
- Molecular Weight : 532.59 
 
	
			                                   
																				(Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)-1-nitrosohydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid
(Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)-1-nitrosohydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid
- Catalogue No.:PA 32 0221000 
- CAS : - NA
- Molecular Formula : C25H21N5O5 
- Molecular Weight : 471.47 
 
	
			                                   
																				2-Aminoethyl (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)-2'-methoxy-[1,1'-biphenyl]-3-carboxylate
2-Aminoethyl (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)-2'-methoxy-[1,1'-biphenyl]-3-carboxylate
- Catalogue No.:PA 32 0221002 
- CAS : - NA
- Molecular Formula : C28H29N5O4 
- Molecular Weight : 499.57 
 
	
			                                   
																				(2S,3S,4S,5R)-6-((3-Acetamido-3'-carboxy-[1,1'-biphenyl]-2-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid
(2S,3S,4S,5R)-6-((3-Acetamido-3'-carboxy-[1,1'-biphenyl]-2-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid
- Catalogue No.:PA 32 0221005 
- CAS : - NA
- Molecular Formula : C21H21NO10 
- Molecular Weight : 447.4 
 
	
			                                   
																				(Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)-2'-hydroxy-N-(2-hydroxyethyl)-[1,1'-biphenyl]-3-carboxamide
(Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)-2'-hydroxy-N-(2-hydroxyethyl)-[1,1'-biphenyl]-3-carboxamide
- Catalogue No.:PA 32 0221007 
- CAS : - NA
- Molecular Formula : C27H27N5O4 
- Molecular Weight : 485.54 
 
	
			                                   
																				3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic Acid
3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic Acid
- Catalogue No.:PA 32 0221014 
- CAS : - 376591-99-0
- Molecular Formula : C25H22N4O4 
- Molecular Weight : 442.48 
 
	
			                                   
																				1,1'',2'-Tris(3,4-dimethylphenyl)-5,5''-dihydroxy-3,3'',5'-trimethyl-1H,1''H-[4,4':4',4''-terpyrazol]-3'(2'H)-one
1,1'',2'-Tris(3,4-dimethylphenyl)-5,5''-dihydroxy-3,3'',5'-trimethyl-1H,1''H-[4,4':4',4''-terpyrazol]-3'(2'H)-one
- Catalogue No.:PA 32 0221015 
- CAS : - 2750368-89-7
- Molecular Formula : C36H38N6O3 
- Molecular Weight : 602.74 
 
	
			                                   
																				3'-(2-((4Z,5Z)-1-(3,4-Dimethylphenyl)-5-(hydroxyimino)-3-methyl-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic Acid
3'-(2-((4Z,5Z)-1-(3,4-Dimethylphenyl)-5-(hydroxyimino)-3-methyl-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic Acid
- Catalogue No.:PA 32 0221021 
- CAS : - NA
- Molecular Formula : C25H23N5O4 
- Molecular Weight : 457.49 
 
	
			                                   
																				Methyl (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)-1-hydroxyhydrazineyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylate
Methyl (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)-1-hydroxyhydrazineyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylate
- Catalogue No.:PAI 32 022001 
- CAS : - NA
- Molecular Formula : C26H24N4O5 
- Molecular Weight : 472.5 
 
	
			                                   
																				Methyl (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazineyl)-2'-methoxy-[1,1'-biphenyl]-3-carboxylate
Methyl (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazineyl)-2'-methoxy-[1,1'-biphenyl]-3-carboxylate
- Catalogue No.:PAI 32 022002 
- CAS : - NA
- Molecular Formula : C27H26N4O4 
- Molecular Weight : 470.53 
 
	
			                                   
																				Methyl (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)-1-nitrosohydrazineyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylate
Methyl (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)-1-nitrosohydrazineyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylate
- Catalogue No.:PA 32 0221026 
- CAS : - NA
- Molecular Formula : C26H23N5O5 
- Molecular Weight : 485.5 
 
	
			                                   
																				(Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)-2'-hydroxy-5'-nitroso-[1,1'-biphenyl]-3-carboxylic Acid
(Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)-2'-hydroxy-5'-nitroso-[1,1'-biphenyl]-3-carboxylic Acid
- Catalogue No.:PA 32 0221027 
- CAS : - NA
- Molecular Formula : C25H21N5O5 
- Molecular Weight : 471.47 
 
	
			                                  ![(Z)-4-(((E)-2-Hydroxy-[1,1'-biphenyl]-3(2H)-yliden PA 32 0221031](https://www.pharmaffiliates.com/pimages/PA320221031.jpg) 
																				(Z)-4-(((E)-2-Hydroxy-[1,1'-biphenyl]-3(2H)-ylidene)hydrazineylidene)-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
(Z)-4-(((E)-2-Hydroxy-[1,1'-biphenyl]-3(2H)-ylidene)hydrazineylidene)-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
- Catalogue No.:PA 32 0221031 
- CAS : - NA
- Molecular Formula : C21H16N4O2 
- Molecular Weight : 356.39 
 
	
			                                   
																				(Z)-2'-Hydroxy-3'-(2-(5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazineyl)-[1,1'-biphenyl]-3-carboxylic Acid
(Z)-2'-Hydroxy-3'-(2-(5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazineyl)-[1,1'-biphenyl]-3-carboxylic Acid
- Catalogue No.:PA 32 0221033 
- CAS : - NA
- Molecular Formula : C22H16N4O4 
- Molecular Weight : 400.39 
 
	
			                                   
																				(Z)-3,4,5-Trihydroxy-6-((2'-hydroxy-3'-(1-hydroxy-2-(5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazineyl)-[1,1'-biphenyl]-3-carbonyl)oxy)tetrahydro-2H-pyran-2-carboxylic Acid
(Z)-3,4,5-Trihydroxy-6-((2'-hydroxy-3'-(1-hydroxy-2-(5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazineyl)-[1,1'-biphenyl]-3-carbonyl)oxy)tetrahydro-2H-pyran-2-carboxylic Acid
- Catalogue No.:PA 32 0221034 
- CAS : - NA
- Molecular Formula : C22H20N4O11 
- Molecular Weight : 516.42 
 
	
			                                   
																				(Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazineyl)-N-(2-hydroxyethyl)-2'-methoxy-[1,1'-biphenyl]-3-carboxamide
(Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazineyl)-N-(2-hydroxyethyl)-2'-methoxy-[1,1'-biphenyl]-3-carboxamide
- Catalogue No.:PA 32 0221042 
- CAS : - NA
- Molecular Formula : C28H29N5O4 
- Molecular Weight : 499.57 
 
	
			                                   
																				2-Aminoethyl (E)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazineyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylate
2-Aminoethyl (E)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazineyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylate
- Catalogue No.:PA 32 0221043 
- CAS : - NA
- Molecular Formula : C27H27N5O4 
- Molecular Weight : 485.54 

 
																				 
																				 
																				 
																				 
																				 
																				![3'-Amino-2'-Hydroxy-[1,1']biphenyl-3-carboxylic Ac PA 32 22590](https://www.pharmaffiliates.com/pimages/PA3222590.jpg) 
																				 
																				 
																				 
																				 
																				 
																				 
																				![2'-Hydroxy-3'-nitro-[1,1'-biphenyl]-3-carboxylic A PA 32 0221010](https://www.pharmaffiliates.com/pimages/PA320221010.jpg) 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				![3'-Amino-2'-methoxy-[1,1'-biphenyl]-3-carboxylic A PA 32 0221023](https://www.pharmaffiliates.com/pimages/PA320221023.jpg) 
																				 
																				 
																				 
																				 
																				![3'-Hydrazineyl-2'-hydroxy-[1,1'-biphenyl]-3-carbox PA 32 0221030](https://www.pharmaffiliates.com/pimages/PA320221030.jpg) 
																				 
																				 
																				![2',3'-Dihydroxy-[1,1'-biphenyl]-3-carboxylic Acid PA 32 0221036](https://www.pharmaffiliates.com/pimages/PA320221036.jpg) 
																				 
																				![2'-(Benzyloxy)-3'-nitro-[1,1'-biphenyl]-3-carboxyl PA 32 0221038](https://www.pharmaffiliates.com/pimages/PA320221038.jpg) 
																				![2'-Methoxy-3'-nitro-[1,1'-biphenyl]-3-carboxylic a PA 32 0221039](https://www.pharmaffiliates.com/pimages/PA320221039.jpg) 
																				 
																				 
																				 
																				 
 
 
 
