eltrombopag and its Impurities
Eltrombopag is used to treat low blood platelet counts in adults with chronic immune thrombocytopenia when certain other medicines, or surgery to remove the spleen, have not worked well enough. It has been recently approved for the treatment of thrombocytopenia in patients with chronic hepatitis C to allow them to initiate and maintain interferon-based therapy.. Reference standards of Eltrombopag API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below


(E)-5'-Chloro-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)-1-hydroxyhydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic Acid
(E)-5'-Chloro-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)-1-hydroxyhydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic Acid
Catalogue No.:PA 32 22540
CAS :
NA
Molecular Formula : C25H21ClN4O5
Molecular Weight : 492.91


(E)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-methoxy-[1,1'-biphenyl]-3-carboxylic Acid
(E)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-methoxy-[1,1'-biphenyl]-3-carboxylic Acid
Catalogue No.:PA 32 22560
CAS :
NA
Molecular Formula : C26H24N4O4
Molecular Weight : 456.49


(Z)-5'-Chloro-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic Acid
(Z)-5'-Chloro-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic Acid
Catalogue No.:PA 32 22570
CAS :
NA
Molecular Formula : C25H21ClN4O4
Molecular Weight : 476.91


(Z)-2'-(Benzyloxy)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-[1,1'-biphenyl]-3-carboxylic Acid
(Z)-2'-(Benzyloxy)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-[1,1'-biphenyl]-3-carboxylic Acid
Catalogue No.:PA 32 22580
CAS :
NA
Molecular Formula : C32H28N4O4
Molecular Weight : 532.59


(Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)-1-nitrosohydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid
(Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)-1-nitrosohydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid
Catalogue No.:PA 32 0221000
CAS :
NA
Molecular Formula : C25H21N5O5
Molecular Weight : 471.47


2-Aminoethyl (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)-2'-methoxy-[1,1'-biphenyl]-3-carboxylate
2-Aminoethyl (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)-2'-methoxy-[1,1'-biphenyl]-3-carboxylate
Catalogue No.:PA 32 0221002
CAS :
NA
Molecular Formula : C28H29N5O4
Molecular Weight : 499.57


(2S,3S,4S,5R)-6-((3-Acetamido-3'-carboxy-[1,1'-biphenyl]-2-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid
(2S,3S,4S,5R)-6-((3-Acetamido-3'-carboxy-[1,1'-biphenyl]-2-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid
Catalogue No.:PA 32 0221005
CAS :
NA
Molecular Formula : C21H21NO10
Molecular Weight : 447.4


(Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)-2'-hydroxy-N-(2-hydroxyethyl)-[1,1'-biphenyl]-3-carboxamide
(Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)-2'-hydroxy-N-(2-hydroxyethyl)-[1,1'-biphenyl]-3-carboxamide
Catalogue No.:PA 32 0221007
CAS :
NA
Molecular Formula : C27H27N5O4
Molecular Weight : 485.54


3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic Acid
3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic Acid
Catalogue No.:PA 32 0221014
CAS :
376591-99-0
Molecular Formula : C25H22N4O4
Molecular Weight : 442.48


1,1'',2'-Tris(3,4-dimethylphenyl)-5,5''-dihydroxy-3,3'',5'-trimethyl-1H,1''H-[4,4':4',4''-terpyrazol]-3'(2'H)-one
1,1'',2'-Tris(3,4-dimethylphenyl)-5,5''-dihydroxy-3,3'',5'-trimethyl-1H,1''H-[4,4':4',4''-terpyrazol]-3'(2'H)-one
Catalogue No.:PA 32 0221015
CAS :
2750368-89-7
Molecular Formula : C36H38N6O3
Molecular Weight : 602.74


 3'-(2-((4Z,5Z)-1-(3,4-Dimethylphenyl)-5-(hydroxyimino)-3-methyl-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic Acid
3'-(2-((4Z,5Z)-1-(3,4-Dimethylphenyl)-5-(hydroxyimino)-3-methyl-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic Acid
Catalogue No.:PA 32 0221021
CAS :
NA
Molecular Formula : C25H23N5O4
Molecular Weight : 457.49


Methyl (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)-1-hydroxyhydrazineyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylate
Methyl (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)-1-hydroxyhydrazineyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylate
Catalogue No.:PAI 32 022001
CAS :
NA
Molecular Formula : C26H24N4O5
Molecular Weight : 472.5


Methyl (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazineyl)-2'-methoxy-[1,1'-biphenyl]-3-carboxylate
Methyl (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazineyl)-2'-methoxy-[1,1'-biphenyl]-3-carboxylate
Catalogue No.:PAI 32 022002
CAS :
NA
Molecular Formula : C27H26N4O4
Molecular Weight : 470.53


Methyl (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)-1-nitrosohydrazineyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylate
Methyl (Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)-1-nitrosohydrazineyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylate
Catalogue No.:PA 32 0221026
CAS :
NA
Molecular Formula : C26H23N5O5
Molecular Weight : 485.5


(Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)-2'-hydroxy-5'-nitroso-[1,1'-biphenyl]-3-carboxylic Acid
(Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)-2'-hydroxy-5'-nitroso-[1,1'-biphenyl]-3-carboxylic Acid
Catalogue No.:PA 32 0221027
CAS :
NA
Molecular Formula : C25H21N5O5
Molecular Weight : 471.47

![(Z)-4-(((E)-2-Hydroxy-[1,1'-biphenyl]-3(2H)-yliden PA 32 0221031](https://www.pharmaffiliates.com/pimages/PA320221031.jpg)
(Z)-4-(((E)-2-Hydroxy-[1,1'-biphenyl]-3(2H)-ylidene)hydrazineylidene)-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
(Z)-4-(((E)-2-Hydroxy-[1,1'-biphenyl]-3(2H)-ylidene)hydrazineylidene)-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
Catalogue No.:PA 32 0221031
CAS :
NA
Molecular Formula : C21H16N4O2
Molecular Weight : 356.39


(Z)-2'-Hydroxy-3'-(2-(5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazineyl)-[1,1'-biphenyl]-3-carboxylic Acid
(Z)-2'-Hydroxy-3'-(2-(5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazineyl)-[1,1'-biphenyl]-3-carboxylic Acid
Catalogue No.:PA 32 0221033
CAS :
NA
Molecular Formula : C22H16N4O4
Molecular Weight : 400.39


(Z)-3,4,5-Trihydroxy-6-((2'-hydroxy-3'-(1-hydroxy-2-(5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazineyl)-[1,1'-biphenyl]-3-carbonyl)oxy)tetrahydro-2H-pyran-2-carboxylic Acid
(Z)-3,4,5-Trihydroxy-6-((2'-hydroxy-3'-(1-hydroxy-2-(5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazineyl)-[1,1'-biphenyl]-3-carbonyl)oxy)tetrahydro-2H-pyran-2-carboxylic Acid
Catalogue No.:PA 32 0221034
CAS :
NA
Molecular Formula : C22H20N4O11
Molecular Weight : 516.42