empagliflozin and its Impurities
Empagliflozin is a sodium glucose co-transporter-2 inhibitor indicated as an adjunct to diet and exercise to improve glycemic control in adult patients with type 2 diabetes.. Reference standards of Empagliflozin API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below


(2R,3S,4S,5R,6S)-2-(4-Chloro-3-(4-(((R)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
(2R,3S,4S,5R,6S)-2-(4-Chloro-3-(4-(((R)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
Catalogue No.:PA 05 0561056
CAS :
NA
Molecular Formula : C23H27ClO7
Molecular Weight : 450.91


(1S,2S,3R,4R,5R)-1-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)hexane-1,2,3,4,5,6-hexaol
(1S,2S,3R,4R,5R)-1-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)hexane-1,2,3,4,5,6-hexaol
Catalogue No.:PA 05 0561070
CAS :
2452301-18-5
Molecular Formula : C23H29ClO8
Molecular Weight : 468.93


(2S,3R,4R,5R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-5-((R)-1,2-dihydroxyethyl)-2-methoxytetrahydrofuran-3,4-diol
(2S,3R,4R,5R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-5-((R)-1,2-dihydroxyethyl)-2-methoxytetrahydrofuran-3,4-diol
Catalogue No.:PA 05 0561072
CAS :
1620758-25-9
Molecular Formula : C24H29ClO8
Molecular Weight : 480.94


(2S,3R,4S,5S,6R)-2-(4-Chloro-3-(4-(((R)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol
(2S,3R,4S,5S,6R)-2-(4-Chloro-3-(4-(((R)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol
Catalogue No.:PA 05 0561073
CAS :
NA
Molecular Formula : C23H27ClO8
Molecular Weight : 466.91


(2S,3S,4S,5R,6S)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
(2S,3S,4S,5R,6S)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
Catalogue No.:PA 05 0561075
CAS :
NA
Molecular Formula : C23H27ClO7
Molecular Weight : 450.91


(2R,3R,4S,5S,6R)-2-(4-Chloro-3-(4-(((R)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol
(2R,3R,4S,5S,6R)-2-(4-Chloro-3-(4-(((R)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol
Catalogue No.:PA 05 0561077
CAS :
NA
Molecular Formula : C23H27ClO8
Molecular Weight : 466.91


(2R,3R,4R,5R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-5-((R)-1,2-dihydroxyethyl)-2-methoxytetrahydrofuran-3,4-diol
(2R,3R,4R,5R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-5-((R)-1,2-dihydroxyethyl)-2-methoxytetrahydrofuran-3,4-diol
Catalogue No.:PA 05 0561078
CAS :
1620758-26-0
Molecular Formula : C24H29ClO8
Molecular Weight : 480.94


(2R,3R,4R,5S,6S)-2-(Acetoxymethyl)-6-(4-chloro-3-(4-(((4-nitrophenyl)sulfonyl)oxy)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl Triacetate
(2R,3R,4R,5S,6S)-2-(Acetoxymethyl)-6-(4-chloro-3-(4-(((4-nitrophenyl)sulfonyl)oxy)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl Triacetate
Catalogue No.:PA 05 0561079
CAS :
NA
Molecular Formula : C33H32ClNO14S
Molecular Weight : 734.12


(2S,3S,4S,5R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-5-((R)-1,2-dihydroxyethyl)tetrahydrofuran-3,4-diol
(2S,3S,4S,5R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-5-((R)-1,2-dihydroxyethyl)tetrahydrofuran-3,4-diol
Catalogue No.:PA 05 0561080
CAS :
NA
Molecular Formula : C23H27ClO7
Molecular Weight : 450.91


(2S,3S,4S,5R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-5-((R)-1,2-dihydroxyethyl)tetrahydrofuran-3,4-diol
(2S,3S,4S,5R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-5-((R)-1,2-dihydroxyethyl)tetrahydrofuran-3,4-diol
Catalogue No.:PA 05 0561081
CAS :
NA
Molecular Formula : C23H27ClO7
Molecular Weight : 450.91


(2R,3R,4S,5S,6R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
(2R,3R,4S,5S,6R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
Catalogue No.:PA 05 0561083
CAS :
2781890-39-7
Molecular Formula : C24H29ClO8
Molecular Weight : 480.94


(2R,3S,4R,5R)-1-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-2,3,4,5,6-pentahydroxyhexan-1-one
(2R,3S,4R,5R)-1-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-2,3,4,5,6-pentahydroxyhexan-1-one
Catalogue No.:PA 05 0561084
CAS :
1620758-30-6
Molecular Formula : C23H27ClO8
Molecular Weight : 466.91


(3R,4S,5S,6R)-2-(4-Chloro-3-(4-hydroxybenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
(3R,4S,5S,6R)-2-(4-Chloro-3-(4-hydroxybenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
Catalogue No.:PA 05 0561085
CAS :
912917-83-0
Molecular Formula : C20H23ClO7
Molecular Weight : 410.85


(2R,3R,4R,5S,6S)-2-(Acetoxymethyl)-6-(4-chloro-3-(4-(((R)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate
(2R,3R,4R,5S,6S)-2-(Acetoxymethyl)-6-(4-chloro-3-(4-(((R)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate
Catalogue No.:PA 05 0561088
CAS :
915095-98-6
Molecular Formula : C31H35ClO11
Molecular Weight : 619.06


(2R,3R,4R,5S,6R)-2-(4-Chloro-3-(4-hydroxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
(2R,3R,4R,5S,6R)-2-(4-Chloro-3-(4-hydroxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
Catalogue No.:PA 05 0561089
CAS :
1118566-46-3
Molecular Formula : C19H21ClO6
Molecular Weight : 380.82


(3R,4S,5R)-5-((R)-2,2,7,7-Tetramethyl-3,6-dioxa-2,7-disilaoctan-4-yl)-3,4-bis((trimethylsilyl)oxy)dihydrofuran-2(3H)-one
(3R,4S,5R)-5-((R)-2,2,7,7-Tetramethyl-3,6-dioxa-2,7-disilaoctan-4-yl)-3,4-bis((trimethylsilyl)oxy)dihydrofuran-2(3H)-one
Catalogue No.:PAI 05 056003
CAS :
2348-31-4
Molecular Formula : C18H42O6Si4
Molecular Weight : 466.87


(2S,3R,4S,5S,6R)-2-(4-Chloro-3-(4-hydroxybenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
(2S,3R,4S,5S,6R)-2-(4-Chloro-3-(4-hydroxybenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
Catalogue No.:PA 05 0561093
CAS :
1204220-63-2
Molecular Formula : C20H23ClO7
Molecular Weight : 410.85


(2S,3R,4S,5S,6R)-2-(4-Chloro-3-(4-hydroxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol
(2S,3R,4S,5S,6R)-2-(4-Chloro-3-(4-hydroxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol
Catalogue No.:PA 05 0561094
CAS :
1054644-05-1
Molecular Formula : C19H21ClO7
Molecular Weight : 396.82


(2-Chloro-5-((3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-2-yl)phenyl)(4-(((S)-tetrahydrofuran-3-yl)oxy)phenyl)methanone
(2-Chloro-5-((3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-2-yl)phenyl)(4-(((S)-tetrahydrofuran-3-yl)oxy)phenyl)methanone
Catalogue No.:PAI 05 056004
CAS :
2125472-54-8
Molecular Formula : C24H27ClO9
Molecular Weight : 494.92


(3R,4R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-5-((R)-1,2-dihydroxyethyl)tetrahydrofuran-3,4-diol
(3R,4R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-5-((R)-1,2-dihydroxyethyl)tetrahydrofuran-3,4-diol
Catalogue No.:PA 05 0561095
CAS :
NA
Molecular Formula : C23H27ClO7
Molecular Weight : 450.91


(2S,3S,4R,5R,6R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl acetate
(2S,3S,4R,5R,6R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl acetate
Catalogue No.:PA 05 0561096
CAS :
NA
Molecular Formula : C25H29ClO8
Molecular Weight : 492.95


(2S,3R,4R,5R)-1-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)hexane-1,2,3,4,5,6-hexaol
(2S,3R,4R,5R)-1-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)hexane-1,2,3,4,5,6-hexaol
Catalogue No.:PA 05 0561104
CAS :
NA
Molecular Formula : C23H29ClO8
Molecular Weight : 468.93


(2R,3R,4R,5R,6S)-2-(Acetoxymethyl)-6-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-5-hydroxy-6-methoxytetrahydro-2H-pyran-3,4-diyl diacetate
(2R,3R,4R,5R,6S)-2-(Acetoxymethyl)-6-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-5-hydroxy-6-methoxytetrahydro-2H-pyran-3,4-diyl diacetate
Catalogue No.:PA 05 0561105
CAS :
NA
Molecular Formula : C30H35ClO11
Molecular Weight : 607.05


(2R,2'R,3S,3'S,4S,4'S,5R,5'R,6S,6'S)-6,6'-((Methylenebis(oxy))bis(methylene))bis(2-(4-chloro-3-(4-(((R)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triol)
(2R,2'R,3S,3'S,4S,4'S,5R,5'R,6S,6'S)-6,6'-((Methylenebis(oxy))bis(methylene))bis(2-(4-chloro-3-(4-(((R)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triol)
Catalogue No.:PA 05 0561108
CAS :
NA
Molecular Formula : C47H54Cl2O14
Molecular Weight : 913.84


(3R,4R,5R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-5-((R)-1,2-dihydroxyethyl)tetrahydrofuran-3,4-diol
(3R,4R,5R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-5-((R)-1,2-dihydroxyethyl)tetrahydrofuran-3,4-diol
Catalogue No.:PA 05 0561110
CAS :
NA
Molecular Formula : C23H27ClO7
Molecular Weight : 450.91


(2S,3R,4R,5S,6R)-2-(4-Chloro-3-(3-(tetrahydrofuran-3-yl)-4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
(2S,3R,4R,5S,6R)-2-(4-Chloro-3-(3-(tetrahydrofuran-3-yl)-4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
Catalogue No.:PA 05 0561111
CAS :
NA
Molecular Formula : C27H33ClO8
Molecular Weight : 521


(2R,3R,4S,5S,6R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-2-((((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)methoxy)methoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
(2R,3R,4S,5S,6R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-2-((((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)methoxy)methoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
Catalogue No.:PA 05 0561116
CAS :
NA
Molecular Formula : C47H54Cl2O15
Molecular Weight : 929.83