Eribulin Mesylate and its Impurities
Eribulin Mesylate, sold under the brand name Halaven, is an anticancer medication used to treat breast cancer and liposarcoma. Reference standards of Eribulin Mesylate API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
(1R,3S,8S,11S,14S,16R,18R,20S,22R,23R,24S,28R,31S,33S,34R,35S,37S)-22-[(2S)-3-Amino-2-hydroxypropyl]-34,37-dihydroxy-23-methoxy-16-methyl-10,17-dimethylidene2,21,32,36,38,39-hexaoxaheptacyclo[26.6.2.13,33.18,11.114,18.020,24.031,35 ]nonatriacontane-5,26-dione
(1R,3S,8S,11S,14S,16R,18R,20S,22R,23R,24S,28R,31S,33S,34R,35S,37S)-22-[(2S)-3-Amino-2-hydroxypropyl]-34,37-dihydroxy-23-methoxy-16-methyl-10,17-dimethylidene2,21,32,36,38,39-hexaoxaheptacyclo[26.6.2.13,33.18,11.114,18.020,24.031,35 ]nonatriacontane-5,26-dione
Catalogue No.:PA 05 1811000
CAS :
NA
Molecular Formula : C40H61NO12
Molecular Weight : 747.92
7,11:10,14:13,16:21,24:27,31-Pentaepoxy-2H-cyclohentriaconta[b]furan-5,18(3H,4H)-dione, 2-[(2S)-3-amino-2-hydroxypropyl]octacosahydro-12,15-dihydroxy-3-methoxy-29-methyl-23,30-bis(methylene)-, (2R,3R,3aS,7R,10S,11R,12S,13S,14S,15S,16R,21S,24S,27S,29R,31R,32aS)
7,11:10,14:13,16:21,24:27,31-Pentaepoxy-2H-cyclohentriaconta[b]furan-5,18(3H,4H)-dione, 2-[(2S)-3-amino-2-hydroxypropyl]octacosahydro-12,15-dihydroxy-3-methoxy-29-methyl-23,30-bis(methylene)-, (2R,3R,3aS,7R,10S,11R,12S,13S,14S,15S,16R,21S,24S,27S,29R,31R,32aS)
Catalogue No.:PA 05 1811001
CAS :
1534341-96-2
Molecular Formula : C40H61NO12
Molecular Weight : 747.92
(1R,2S,3S,4S,5S,6R,11S,14S,17S,19R,21R,23S,25R,26R,27S,31R,34S)-25-[(2S)-3-Amino-2-hydroxypropyl]-2,5-dihydroxy-26-methoxy-19-methyl-13,20-dimethylidene-24,35,36,37,38,39-hexaoxaheptacyclo[29.3.1.13,6.14,34.111,14.117,21.023,27]nonatriacontane-8,29-dione
(1R,2S,3S,4S,5S,6R,11S,14S,17S,19R,21R,23S,25R,26R,27S,31R,34S)-25-[(2S)-3-Amino-2-hydroxypropyl]-2,5-dihydroxy-26-methoxy-19-methyl-13,20-dimethylidene-24,35,36,37,38,39-hexaoxaheptacyclo[29.3.1.13,6.14,34.111,14.117,21.023,27]nonatriacontane-8,29-dione
Catalogue No.:PA 05 1811002
CAS :
NA
Molecular Formula : C40H61NO12
Molecular Weight : 747.92
(2R,3R,3aS,7R,8aS,9S,10aR,11S,12R,13aR,13bS,15S,18S,21S,24S,26R,28R,29aS)-2-[(2R)-3-Amino-2-hydroxypropyl]-3-methoxy-26-methyl-20,27-dimethylidenehexacosahydro-11,15:18,21:24,28-triepoxy-7,9-ethano-12,15-methano-9H,15H-furo[3,2-i]furo[2',3':5,6]pyrano[4,3-b][1,4]dioxacyclopentacosin-5(4H)-one
(2R,3R,3aS,7R,8aS,9S,10aR,11S,12R,13aR,13bS,15S,18S,21S,24S,26R,28R,29aS)-2-[(2R)-3-Amino-2-hydroxypropyl]-3-methoxy-26-methyl-20,27-dimethylidenehexacosahydro-11,15:18,21:24,28-triepoxy-7,9-ethano-12,15-methano-9H,15H-furo[3,2-i]furo[2',3':5,6]pyrano[4,3-b][1,4]dioxacyclopentacosin-5(4H)-one
Catalogue No.:PA 05 1811004
CAS :
1190091-21-4
Molecular Formula : C40H59NO11
Molecular Weight : 729.91
(2R,3R,3aS,7R,8aS,9S,10aR,11S,12R,13aR,13bS,15S,18S,21S,24S,26R,28R,29aS)-2-[(2S)-2,3-Dihydroxypropyl]-3-methoxy-26-methyl-20,27-dimethylidenehexacosahydro-11,15:18,21:24,28-triepoxy-7,9-ethano-12,15-methano-9H,15H-furo[3,2-i]furo[2?,3?:5,6]pyrano[4,3-b][1,4]dioxacyclopentacosin-5(4H)-one
(2R,3R,3aS,7R,8aS,9S,10aR,11S,12R,13aR,13bS,15S,18S,21S,24S,26R,28R,29aS)-2-[(2S)-2,3-Dihydroxypropyl]-3-methoxy-26-methyl-20,27-dimethylidenehexacosahydro-11,15:18,21:24,28-triepoxy-7,9-ethano-12,15-methano-9H,15H-furo[3,2-i]furo[2?,3?:5,6]pyrano[4,3-b][1,4]dioxacyclopentacosin-5(4H)-one
Catalogue No.:PA 05 1811005
CAS :
253128-15-3
Molecular Formula : C40H58O12
Molecular Weight : 730.89
