ertugliflozin and its Impurities
Ertugliflozin is a glucose cotransporter 2 inhibitor and is in the class of drugs known as gliflozins. It is use as a monotherapy and as a fixed dose combination with either sitagliptin or with metformin.. Reference standards of Ertugliflozin API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below
(1S,2S,3S,4S,5S)-5-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol
(1S,2S,3S,4S,5S)-5-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol
Catalogue No.:PA 32 12520
CAS :
1210344-58-3
Molecular Formula : C22H25ClO7
Molecular Weight : 436.89
(1S,2S,3S,4R,5S)-5-(4-Chloro-3-(4-(2-hydroxyethoxy)benzyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol
(1S,2S,3S,4R,5S)-5-(4-Chloro-3-(4-(2-hydroxyethoxy)benzyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol
Catalogue No.:PA 32 0121005
CAS :
1298086-24-4
Molecular Formula : C22H25ClO8
Molecular Weight : 452.88
(1S,2S,3S,4R,5S)-5-(4-Chloro-3-((4-ethoxyphenyl)(hydroxy)methyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol
(1S,2S,3S,4R,5S)-5-(4-Chloro-3-((4-ethoxyphenyl)(hydroxy)methyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol
Catalogue No.:PA 32 0121002
CAS :
1298086-28-8
Molecular Formula : C22H25ClO8
Molecular Weight : 452.88
(1S,2S,3S,4R,5S)-5-(4-Chloro-3-(4-hydroxybenzyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol
(1S,2S,3S,4R,5S)-5-(4-Chloro-3-(4-hydroxybenzyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol
Catalogue No.:PA 32 0121001
CAS :
1298086-17-5
Molecular Formula : C20H21ClO7
Molecular Weight : 408.83
(2S,3R,4S,5S)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6,6-bis(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
(2S,3R,4S,5S)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6,6-bis(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
Catalogue No.:PA 32 0121007
CAS :
1528636-39-6
Molecular Formula : C23H29ClO8
Molecular Weight : 468.93
(2S,3S,4S,5R,6S)-6-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-3,4,5-trihydroxy-6-methoxytetrahydro-2H-pyran-2-carboxylic Acid
(2S,3S,4S,5R,6S)-6-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-3,4,5-trihydroxy-6-methoxytetrahydro-2H-pyran-2-carboxylic Acid
Catalogue No.:PA 32 0121009
CAS :
1528636-47-6
Molecular Formula : C22H25ClO8
Molecular Weight : 452.88
(2R,3R,4S,5S,6R)-2-(2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
(2R,3R,4S,5S,6R)-2-(2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
Catalogue No.:PA 32 0121012
CAS :
NA
Molecular Formula : C27H37ClN2O7
Molecular Weight : 537.05
(2R,3S,4S,5R)-2-(2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethoxy)-2,5-bis(hydroxymethyl)tetrahydrofuran-3,4-diol
(2R,3S,4S,5R)-2-(2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethoxy)-2,5-bis(hydroxymethyl)tetrahydrofuran-3,4-diol
Catalogue No.:PA 32 0121013
CAS :
NA
Molecular Formula : C27H37ClN2O7
Molecular Weight : 537.05
(1R,2S,3S,4R,5R)-5-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol
(1R,2S,3S,4R,5R)-5-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol
Catalogue No.:PA 32 0121014
CAS :
NA
Molecular Formula : C22H25ClO7
Molecular Weight : 436.89
