exemestane and its Impurities
Exemestane is used in the adjuvant treatment of hormonally-responsive breast cancer in postmenopausal women. It irreversibly binds to the active site of the enzyme resulting in permanent inhibition. It is an oral steroidal aromatase inhibitor.. Reference standards of Exemestane API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below


(6aR,6bS,8aS,8bS,9aR,10aS,10bR)-6a,8a-Dimethyl-2-methylene-1,2,6a,6b,7,8,8a,8b,9a,10,10a,10b-dodecahydro-4H-naphtho[2',1':4,5]indeno[1,2-b]oxiren-4-one
(6aR,6bS,8aS,8bS,9aR,10aS,10bR)-6a,8a-Dimethyl-2-methylene-1,2,6a,6b,7,8,8a,8b,9a,10,10a,10b-dodecahydro-4H-naphtho[2',1':4,5]indeno[1,2-b]oxiren-4-one
Catalogue No.:PA 05 54610
CAS :
NA
Molecular Formula : C20H24O2
Molecular Weight : 296.41


(8R,9S,13S,14S)-1-Hydroxy-4,13-dimethyl-6,7,8,9,11,12,13,14,15,16-decahydro-17H-cyclopenta[a]phenanthren-17-one
(8R,9S,13S,14S)-1-Hydroxy-4,13-dimethyl-6,7,8,9,11,12,13,14,15,16-decahydro-17H-cyclopenta[a]phenanthren-17-one
Catalogue No.:PA 05 0541002
CAS :
4954-08-9
Molecular Formula : C19H24O2
Molecular Weight : 284.4


((8R,9S,10R,13S,14S)-10,13-Dimethyl-3,17-dioxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-6-yl)methyl methanesulfonate
((8R,9S,10R,13S,14S)-10,13-Dimethyl-3,17-dioxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-6-yl)methyl methanesulfonate
Catalogue No.:PA 05 0541004
CAS :
861395-77-9
Molecular Formula : C21H28O5S
Molecular Weight : 392.51


(8R,9S,10R,13S,14S)-6-(Methoxymethyl)-10,13-dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-3H-cyclopenta[a]phenanthrene-3,17(6H)-dione
(8R,9S,10R,13S,14S)-6-(Methoxymethyl)-10,13-dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-3H-cyclopenta[a]phenanthrene-3,17(6H)-dione
Catalogue No.:PA 05 0541008
CAS :
861398-01-8
Molecular Formula : C21H28O3
Molecular Weight : 328.45


(8R,9S,10R,13S,14S)-10,13-Dimethyl-3,17-dioxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-6-carbaldehyde
(8R,9S,10R,13S,14S)-10,13-Dimethyl-3,17-dioxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-6-carbaldehyde
Catalogue No.:PA 05 0541011
CAS :
NA
Molecular Formula : C20H24O3
Molecular Weight : 312.41


(8R,9S,10R,13S,14S)-17-Hydroxy-10,13-dimethyl-3-oxo-8,9,10,11,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthrene-6-carbaldehyde
(8R,9S,10R,13S,14S)-17-Hydroxy-10,13-dimethyl-3-oxo-8,9,10,11,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthrene-6-carbaldehyde
Catalogue No.:PA 05 0541012
CAS :
NA
Molecular Formula : C20H24O3
Molecular Weight : 312.41


(8R,9S,10R,13S,14S)-3-Ethoxy-10,13-dimethyl-6-methylene-1,2,3,6,7,8,9,10,11,12,13,14,15,16-tetradecahydro-17H-cyclopenta[a]phenanthren-17-one
(8R,9S,10R,13S,14S)-3-Ethoxy-10,13-dimethyl-6-methylene-1,2,3,6,7,8,9,10,11,12,13,14,15,16-tetradecahydro-17H-cyclopenta[a]phenanthren-17-one
Catalogue No.:PA 05 0541013
CAS :
NA
Molecular Formula : C22H32O2
Molecular Weight : 328.5


((6S,8R,9S,10R,13S,14S)-10,13-dimethyl-3,17-dioxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-6-yl)methyl methanesulfonate
((6S,8R,9S,10R,13S,14S)-10,13-dimethyl-3,17-dioxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-6-yl)methyl methanesulfonate
Catalogue No.:PA 05 0541014
CAS :
NA
Molecular Formula : C21H28O5S
Molecular Weight : 392.51