ezetimibe and its Impurities
An anti-hyperlipidemic medication, it is used for cholesterol lowering that decreases the absorption of cholesterol in the small intestine. Ezetimibe is hence used for treating high cholesterol. Reference standards of Ezetimibe API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


(3R,4S)-4-(4-(Benzyloxy)phenyl)-1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-3-oxopropyl)azetidin-2-one
(3R,4S)-4-(4-(Benzyloxy)phenyl)-1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-3-oxopropyl)azetidin-2-one
Catalogue No.:PA 05 41640
CAS :
190595-65-4
Molecular Formula : C31H25F2NO3
Molecular Weight : 497.53


(4S3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-2-oxazolidinone
(4S3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-2-oxazolidinone
Catalogue No.:PA 05 41670
CAS :
272778-12-8
Molecular Formula : C39H46F2N2O5Si2
Molecular Weight : 716.96


(4S)-3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino](4-hydroxyphenyl)methyl]-5-hydroxy-1-oxopentyl]-4-phenyl-2-oxazolidinone
(4S)-3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino](4-hydroxyphenyl)methyl]-5-hydroxy-1-oxopentyl]-4-phenyl-2-oxazolidinone
Catalogue No.:PA 05 41920
CAS :
1185883-40-2
Molecular Formula : C33H30F2N2O5
Molecular Weight : 572.6


(S)-3-((2R,5S)-5-(4-Fluorophenyl)-2-((S)-((4-fluorophenyl)amino)(4-hydroxyphenyl)methyl)-5-((trimethylsilyl)oxy)pentanoyl)-4-phenyloxazolidin-2-one
(S)-3-((2R,5S)-5-(4-Fluorophenyl)-2-((S)-((4-fluorophenyl)amino)(4-hydroxyphenyl)methyl)-5-((trimethylsilyl)oxy)pentanoyl)-4-phenyloxazolidin-2-one
Catalogue No.:PA 05 41940
CAS :
NA
Molecular Formula : C36H38F2N2O5Si
Molecular Weight : 644.78


(4S)-3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(R)-[(3-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-2-oxazolidinone
(4S)-3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(R)-[(3-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-2-oxazolidinone
Catalogue No.:PA 05 41950
CAS :
NA
Molecular Formula : C39H46F2N2O5Si2
Molecular Weight : 716.96


(S)-3-((2R,5R)-5-(4-Fluorophenyl)-2-((S)-((4-fluorophenyl)amino)(4-((trimethylsilyl)oxy)phenyl)methyl)-5-((trimethylsilyl)oxy)pentanoyl)-4-phenyloxazolidin-2-one
(S)-3-((2R,5R)-5-(4-Fluorophenyl)-2-((S)-((4-fluorophenyl)amino)(4-((trimethylsilyl)oxy)phenyl)methyl)-5-((trimethylsilyl)oxy)pentanoyl)-4-phenyloxazolidin-2-one
Catalogue No.:PA 05 41960
CAS :
1809031-15-9
Molecular Formula : C39H46F2N2O5Si2
Molecular Weight : 716.96


(3R,4S)-1-(4-Fluorophenyl)-3-[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one
(3R,4S)-1-(4-Fluorophenyl)-3-[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one
Catalogue No.:PAI 05 001510
CAS :
163222-33-1
Molecular Formula : C24H21F2NO3
Molecular Weight : 409.40


(3R,4S)-1-(4-Fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one
(3R,4S)-1-(4-Fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one
Catalogue No.:PAI 05 001020
CAS :
438576-93-3
Molecular Formula : C24H21F2NO3
Molecular Weight : 409.43


(S)-3-((2S,3R)-2-(4-(Benzyloxy)phenyl)-1-(4-fluorophenyl)-4-oxoazetidin-3-yl)-1-(4-fluorophenyl)propyl acetate
(S)-3-((2S,3R)-2-(4-(Benzyloxy)phenyl)-1-(4-fluorophenyl)-4-oxoazetidin-3-yl)-1-(4-fluorophenyl)propyl acetate
Catalogue No.:PAI 05 001030
CAS :
NA
Molecular Formula : C33H29F2NO4
Molecular Weight : 541.58


4-((2S,3R)-1-(4-Fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-oxoazetidin-2-yl)phenyl Acetate
4-((2S,3R)-1-(4-Fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-oxoazetidin-2-yl)phenyl Acetate
Catalogue No.:PAI 05 001090
CAS :
NA
Molecular Formula : C26H23F2NO4
Molecular Weight : 451.46


4-((2S,3R)-3-((S)-3-(Benzyloxy)-3-(4-fluorophenyl)propyl)-1-(4-fluorophenyl)-4-oxoazetidin-2-yl)phenyl Acetate
4-((2S,3R)-3-((S)-3-(Benzyloxy)-3-(4-fluorophenyl)propyl)-1-(4-fluorophenyl)-4-oxoazetidin-2-yl)phenyl Acetate
Catalogue No.:PAI 05 001100
CAS :
NA
Molecular Formula : C33H29F2NO4
Molecular Weight : 541.58


(4R)-3-((2R,5S)-5-(Benzyloxy)-2-((4-(benzyloxy)phenyl)((3-fluorophenyl)amino)methyl)-5-(4-fluorophenyl)pentanoyl)-4-phenyloxazolidin-2-one
(4R)-3-((2R,5S)-5-(Benzyloxy)-2-((4-(benzyloxy)phenyl)((3-fluorophenyl)amino)methyl)-5-(4-fluorophenyl)pentanoyl)-4-phenyloxazolidin-2-one
Catalogue No.:PAI 05 001120
CAS :
NA
Molecular Formula : C47H42F2N2O5
Molecular Weight : 752.86


(3R,4S)-3-((S)-3-(Benzyloxy)-3-(4-fluorophenyl)propyl)-4-(4-(benzyloxy)phenyl)-1-(3-fluorophenyl)azetidin-2-one
(3R,4S)-3-((S)-3-(Benzyloxy)-3-(4-fluorophenyl)propyl)-4-(4-(benzyloxy)phenyl)-1-(3-fluorophenyl)azetidin-2-one
Catalogue No.:PAI 05 001130
CAS :
NA
Molecular Formula : C38H33F2NO3
Molecular Weight : 589.68


(4R)-3-((2R,5S)-2-((4-(Benzyloxy)phenyl)((3-fluorophenyl)amino)methyl)-5-(4-fluorophenyl)-5-((trimethylsilyl)oxy)pentanoyl)-4-phenyloxazolidin-2-one
(4R)-3-((2R,5S)-2-((4-(Benzyloxy)phenyl)((3-fluorophenyl)amino)methyl)-5-(4-fluorophenyl)-5-((trimethylsilyl)oxy)pentanoyl)-4-phenyloxazolidin-2-one
Catalogue No.:PAI 05 001180
CAS :
NA
Molecular Formula : C43H44F2N2O5Si
Molecular Weight : 734.92


(3R,4S)-4-(4-(Benzyloxy)phenyl)-1-(3-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-((trimethylsilyl)oxy)propyl)azetidin-2-one
(3R,4S)-4-(4-(Benzyloxy)phenyl)-1-(3-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-((trimethylsilyl)oxy)propyl)azetidin-2-one
Catalogue No.:PAI 05 001190
CAS :
NA
Molecular Formula : C34H35F2NO3Si
Molecular Weight : 571.74


(4S)-3-((2R)-2-((4-((tert-Butyldimethylsilyl)oxy)phenyl)((3-fluorophenyl)amino)methyl)-5-(4-fluorophenyl)-5,5-dimethoxypentanoyl)-4-phenyloxazolidin-2-one
(4S)-3-((2R)-2-((4-((tert-Butyldimethylsilyl)oxy)phenyl)((3-fluorophenyl)amino)methyl)-5-(4-fluorophenyl)-5,5-dimethoxypentanoyl)-4-phenyloxazolidin-2-one
Catalogue No.:PAI 05 001210
CAS :
NA
Molecular Formula : C41H48F2N2O6Si
Molecular Weight : 730.92


(3R,4S)-4-(4-((tert-Butyldimethylsilyl)oxy)phenyl)-1-(3-fluorophenyl)-3-(3-(4-fluorophenyl)-3-oxopropyl)azetidin-2-one
(3R,4S)-4-(4-((tert-Butyldimethylsilyl)oxy)phenyl)-1-(3-fluorophenyl)-3-(3-(4-fluorophenyl)-3-oxopropyl)azetidin-2-one
Catalogue No.:PAI 05 001220
CAS :
NA
Molecular Formula : C30H33F2NO3Si
Molecular Weight : 521.68


(3R,4S)-4-(4-((tert-Butyldimethylsilyl)oxy)phenyl)-1-(3-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)azetidin-2-one
(3R,4S)-4-(4-((tert-Butyldimethylsilyl)oxy)phenyl)-1-(3-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)azetidin-2-one
Catalogue No.:PAI 05 001230
CAS :
NA
Molecular Formula : C30H35F2NO3Si
Molecular Weight : 523.70