fluticasone and its Impurities
A synthetic glucocorticoid, ester derivatives of Fluticasone are used as topical anti-inflammatory agents. It is also used to treat allergic and non-allergic nasal symptoms. Ths corticosteroid is also used for treating eye allergies. Reference standards of Fluticasone API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


Fluticasone Propionate - Impurity G (Freebase)
6α,9-Difluoro-17-[[(fluoromethyl)sulfanyl]carbonyl]-11β-hydroxy-16α-methyl-3-oxoandrosta1,4-dien-17α-yl 6α,9-difluoro-11β,17-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carboxylate
Catalogue No.:PA 06 42070
CAS :
220589-37-7
Molecular Formula : C43H51F5O8S
Molecular Weight : 822.92


(6S,6'S,8S,8'S,9R,9'R,10S,10'S,11S,11'S,13S,13'S,14S,14'S,16R,16'R,17R,17'R)-((Methylenebis(sulfanediyl))bis(carbonyl))bis(6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17,17-diyl) Dipropionate
(6S,6'S,8S,8'S,9R,9'R,10S,10'S,11S,11'S,13S,13'S,14S,14'S,16R,16'R,17R,17'R)-((Methylenebis(sulfanediyl))bis(carbonyl))bis(6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17,17-diyl) Dipropionate
Catalogue No.:PA 06 42550
CAS :
192191-51-8
Molecular Formula : C49H60F4O10S2
Molecular Weight : 949.12


5-Iodomethyl 6α,9α-Difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-(propionyloxy)-androsta-1,4-diene-17β-carbothioate
5-Iodomethyl 6α,9α-Difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-(propionyloxy)-androsta-1,4-diene-17β-carbothioate
Catalogue No.:PA 06 42560
CAS :
80474-67-5
Molecular Formula : C25H31F2IO5S
Molecular Weight : 608.48


2-((4aS,4bS,5aS,6aS,7R,8R,11S)-11-Chloro-7-hydroxy-4a,6a,8-trimethyl-2-oxo-2,4a,5a,6,6a,7,8,9,9a,9b,10,11-dodecahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-7-yl)-2-oxoethyl Acetate
2-((4aS,4bS,5aS,6aS,7R,8R,11S)-11-Chloro-7-hydroxy-4a,6a,8-trimethyl-2-oxo-2,4a,5a,6,6a,7,8,9,9a,9b,10,11-dodecahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-7-yl)-2-oxoethyl Acetate
Catalogue No.:PA 06 42570
CAS :
NA
Molecular Formula : C24H29ClO6
Molecular Weight : 448.94


Androsta-1,4-diene-17-carbothioic acid,6,9-difluoro-17-{(2-furanylcarbonyl)oxy}-11-hydroxy-16-methyl-3-oxo-,S-methyl ester, (6α,11β,16α,17α)
Androsta-1,4-diene-17-carbothioic acid,6,9-difluoro-17-{(2-furanylcarbonyl)oxy}-11-hydroxy-16-methyl-3-oxo-,S-methyl ester, (6α,11β,16α,17α)
Catalogue No.:PA 06 82530
CAS :
397864-58-3
Molecular Formula : C27H30F2O6S
Molecular Weight : 520.59


6α,9-Difluoro-11-hydroxy-16α-methyl-3-oxo-androsta-1,4-diene-17-yl-2-furancarboxylate carbothioic S-acid
6α,9-Difluoro-11-hydroxy-16α-methyl-3-oxo-androsta-1,4-diene-17-yl-2-furancarboxylate carbothioic S-acid
Catalogue No.:PA 06 82540
CAS :
397864-40-3
Molecular Formula : C26H28F2O6S
Molecular Weight : 506.56


6α,9α-Difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-(3,3,3-d3-propionyloxy)-androsta-1,4-diene-17β-carbothioic Acid
6α,9α-Difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-(3,3,3-d3-propionyloxy)-androsta-1,4-diene-17β-carbothioic Acid
Catalogue No.:PA STI 031700
CAS :
NA
Molecular Formula : C24H27D3F2O5S
Molecular Weight : 471.57


5-Iodomethyl 6α,9α-Difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-(3,3,3-d3-propionyloxy)-androsta-1,4-diene-17β-carbothioate
5-Iodomethyl 6α,9α-Difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-(3,3,3-d3-propionyloxy)-androsta-1,4-diene-17β-carbothioate
Catalogue No.:PA STI 053330
CAS :
NA
Molecular Formula : C25H28D3F2IO5S
Molecular Weight : 611.5


(6α,11β,16α,17α)-(6'α,11'β,16'α,17'α)-17,17'-(Trithiodicarbonyl)bis[6,9-difluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-androsta-1,4-dien-3-one-d6
(6α,11β,16α,17α)-(6'α,11'β,16'α,17'α)-17,17'-(Trithiodicarbonyl)bis[6,9-difluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-androsta-1,4-dien-3-one-d6
Catalogue No.:PA STI 085720
CAS :
NA
Molecular Formula : C48H52D6F4O10S3
Molecular Weight : 973.19


Fluticasone Propionate Related Compound J (6alpha, 9alpha-difluoro-11beta,17alpha-dihydroxy-16alpha (1285818)
Fluticasone Propionate Related Compound J (6alpha, 9alpha-difluoro-11beta,17alpha-dihydroxy-16alpha (1285818)
Catalogue No.:PA USP1285818
CAS :
28416-82-2
Molecular Formula : NA
Molecular Weight : NA


Fluticasone Propionate Related Compound D (S-methyl 6alpha, 9alpha-difluoro-11beta-hydroxy-16alpha- (1285829)
Fluticasone Propionate Related Compound D (S-methyl 6alpha, 9alpha-difluoro-11beta-hydroxy-16alpha- (1285829)
Catalogue No.:PA USP1285829
CAS :
73205-13-7
Molecular Formula : NA
Molecular Weight : NA


Fluticasone Propionate System Suitability Mixture (Fluticasone Propionate and Fluticasone Propionat (1285895)
Fluticasone Propionate System Suitability Mixture (Fluticasone Propionate and Fluticasone Propionat (1285895)
Catalogue No.:PA USP1285895
CAS :
NA
Molecular Formula : NA
Molecular Weight : NA


(6S,8S,9R,10S,11S,13S,14S,16R)-6-Chloro-9-fluoro-17-(((fluoromethyl)thio)carbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate
(6S,8S,9R,10S,11S,13S,14S,16R)-6-Chloro-9-fluoro-17-(((fluoromethyl)thio)carbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate
Catalogue No.:PA 06 42600
CAS :
NA
Molecular Formula : C25H31ClF2O5S
Molecular Weight : 517.02


(4aS,4bS,5aS,6aS,8R,9aS,11S)-11-Chloro-7-(((fluoromethyl)thio)carbonyl)-4a,6a,8-trimethyl-2-oxo-2,4a,5a,6,6a,7,8,9,9a,9b,10,11-dodecahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-7-yl Propionate
(4aS,4bS,5aS,6aS,8R,9aS,11S)-11-Chloro-7-(((fluoromethyl)thio)carbonyl)-4a,6a,8-trimethyl-2-oxo-2,4a,5a,6,6a,7,8,9,9a,9b,10,11-dodecahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-7-yl Propionate
Catalogue No.:PA 06 42610
CAS :
NA
Molecular Formula : C25H30ClFO5S
Molecular Weight : 497.02


(6S,6'S,8S,8'S,9R,9'R,10S,10'S,11S,11'S,13S,13'S,14S,14'S,16R,16'R,17R,17'R)-((Methylenebis(sulfanediyl))bis(carbonyl))bis(6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17,17-diyl) bis(furan-2-carboxylate)
(6S,6'S,8S,8'S,9R,9'R,10S,10'S,11S,11'S,13S,13'S,14S,14'S,16R,16'R,17R,17'R)-((Methylenebis(sulfanediyl))bis(carbonyl))bis(6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17,17-diyl) bis(furan-2-carboxylate)
Catalogue No.:PA 06 42620
CAS :
NA
Molecular Formula : C53H56F4O12S2
Molecular Weight : 1025.13


(3aR,4R,5aS,5bS,7S,11aS,11bR,12S,13aS)-7,11b-Difluoro-12-hydroxy-4,11a-dimethyl-3,9-dioxo-5,5a,5b,6,7,9,11a,11b,12,13-decahydro-1H,3H-naphtho[2',1':4,5]indeno[1,7a-c]thiophen-3a(4H)-yl Propionate;
(3aR,4R,5aS,5bS,7S,11aS,11bR,12S,13aS)-7,11b-Difluoro-12-hydroxy-4,11a-dimethyl-3,9-dioxo-5,5a,5b,6,7,9,11a,11b,12,13-decahydro-1H,3H-naphtho[2',1':4,5]indeno[1,7a-c]thiophen-3a(4H)-yl Propionate;
Catalogue No.:PA 06 42660
CAS :
NA
Molecular Formula : C24H28F2O5S
Molecular Weight : 466.54


(6S,8S,9R,10S,11S,13S,14S,16R,17S)-6,9-Difluoro-17-(((fluoromethyl)thio)carbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate
(6S,8S,9R,10S,11S,13S,14S,16R,17S)-6,9-Difluoro-17-(((fluoromethyl)thio)carbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate
Catalogue No.:PA 06 42670
CAS :
NA
Molecular Formula : C25H31F3O5S
Molecular Weight : 500.57


Methyl (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(propionyloxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylate
Methyl (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(propionyloxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylate
Catalogue No.:PA 06 42690
CAS :
59860-80-9
Molecular Formula : C25H32F2O6
Molecular Weight : 466.52


6α,9α-Difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-(furoyloxy)-androsta-1,4-diene-17β-carboxylic Acid
6α,9α-Difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-(furoyloxy)-androsta-1,4-diene-17β-carboxylic Acid
Catalogue No.:PA 06 0821000
CAS :
397864-63-0
Molecular Formula : C26H28F2O7
Molecular Weight : 490.49


(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-17-(((fluoromethoxy)thio)carbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl furan-2-carboxylate
(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-17-(((fluoromethoxy)thio)carbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl furan-2-carboxylate
Catalogue No.:PA 33 0301000
CAS :
948569-98-0
Molecular Formula : C27H29F3O7S
Molecular Weight : 554.58


(6S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbothioic S-acid
(6S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbothioic S-acid
Catalogue No.:PAI 06 009041
CAS :
NA
Molecular Formula : C21H26F2O4S
Molecular Weight : 412.49


(6S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-17-((furan-2-carbonyl)oxy)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbothioic S-acid
(6S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-17-((furan-2-carbonyl)oxy)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbothioic S-acid
Catalogue No.:PAI 06 009042
CAS :
NA
Molecular Formula : C26H28F2O6S
Molecular Weight : 506.56


(6R,8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-17-(((fluoromethyl)thio)carbonyl)-6,11-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate
(6R,8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-17-(((fluoromethyl)thio)carbonyl)-6,11-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate
Catalogue No.:PA 06 0421000
CAS :
1059606-32-4
Molecular Formula : C25H32F2O6S
Molecular Weight : 498.58


(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-17-((furan-2-carbonyl)oxy)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H- cyclopenta[a] phenanthrene-17-carboxylic dimethylcarbamic thioanhydride
(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-17-((furan-2-carbonyl)oxy)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H- cyclopenta[a] phenanthrene-17-carboxylic dimethylcarbamic thioanhydride
Catalogue No.:PA 33 0301001
CAS :
948565-92-2
Molecular Formula : C29H33F2NO7S
Molecular Weight : 577.64


(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-17-((furan-2-carbonyl)oxy)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic hypoiodous thioanhydride
(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-17-((furan-2-carbonyl)oxy)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic hypoiodous thioanhydride
Catalogue No.:PA 33 0301002
CAS :
NA
Molecular Formula : C26H27F2IO6S
Molecular Weight : 632.46


(4aS,4bS,5aS,6aS,7R,8R,9aS,9bS,11S)-11-Fluoro-7-(((Fluoromethyl)thio)carbonyl)-4a,6a,8-trimethyl-2-oxo-2,4a,5a,6,6a,7,8,9,9a,9b,10,11-dodecahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-7-yl propionate
(4aS,4bS,5aS,6aS,7R,8R,9aS,9bS,11S)-11-Fluoro-7-(((Fluoromethyl)thio)carbonyl)-4a,6a,8-trimethyl-2-oxo-2,4a,5a,6,6a,7,8,9,9a,9b,10,11-dodecahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-7-yl propionate
Catalogue No.:PA 33 0301003
CAS :
192191-49-4
Molecular Formula : C25H30F2O5S
Molecular Weight : 480.57


(8S,9R,10S,11S,13S,14S,16R,17R)-9-Fluoro-17-((furan-2-carbonyl)oxy)-11-hydroxy-10,13,16-trimethyl-3,6-dioxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid
(8S,9R,10S,11S,13S,14S,16R,17R)-9-Fluoro-17-((furan-2-carbonyl)oxy)-11-hydroxy-10,13,16-trimethyl-3,6-dioxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid
Catalogue No.:PA 06 0421001
CAS :
1807652-41-0
Molecular Formula : C26H27FO8
Molecular Weight : 486.49


17-Acetoxy-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic dimethylcarbamic thioanhydride
17-Acetoxy-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic dimethylcarbamic thioanhydride
Catalogue No.:PAI 33 030001
CAS :
NA
Molecular Formula : C26H33F2NO6S
Molecular Weight : 525.61


(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic dimethylcarbamic Thioanhydride
(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic dimethylcarbamic Thioanhydride
Catalogue No.:PAI 06 009043
CAS :
709002-84-6
Molecular Formula : C24H31F2NO5S
Molecular Weight : 483.57