fosaprepitant dimeglumine and its Impurities
Fosaprepitant Dimeglumine is aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment. It is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant. Reference standards of Fosaprepitant Dimeglumine API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
3-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-5(4H)-one
3-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-5(4H)-one
Catalogue No.:PA 06 94570
CAS :
NA
Molecular Formula : C23H21F7N4O3
Molecular Weight : 534.43
(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentaol hemi((3-(((2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonate)
(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentaol hemi((3-(((2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonate)
Catalogue No.:PA 06 94580
CAS :
NA
Molecular Formula : C37H56F7N6O16P
Molecular Weight : 1004.83
(2R,3R,4R,5S)-6-(Methylamino)hexane-1,2,3,4,5-pentaol hemi((3-(((2R,3R)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonate)
(2R,3R,4R,5S)-6-(Methylamino)hexane-1,2,3,4,5-pentaol hemi((3-(((2R,3R)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonate)
Catalogue No.:PA 06 94600
CAS :
NA
Molecular Formula : C37H56F7N6O16P
Molecular Weight : 1004.83
Methyl (E)-2-(1-amino-2-((2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)ethylidene)hydrazine-1-carboxylate
Methyl (E)-2-(1-amino-2-((2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)ethylidene)hydrazine-1-carboxylate
Catalogue No.:PA 06 94610
CAS :
NA
Molecular Formula : C24H25F7N4O4
Molecular Weight : 566.48
(4-Benzyl-3-(((2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(p-tolyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic Acid
(4-Benzyl-3-(((2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(p-tolyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic Acid
Catalogue No.:PA 06 94630
CAS :
NA
Molecular Formula : C31H31F6N4O6P
Molecular Weight : 700.58
Methyl (Z)-2-(1-amino-2-((2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)ethylidene)hydrazine-1-carboxylate
Methyl (Z)-2-(1-amino-2-((2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)ethylidene)hydrazine-1-carboxylate
Catalogue No.:PA 06 94650
CAS :
1803189-49-2
Molecular Formula : C24H25F7N4O4
Molecular Weight : 566.48
(2R,3R,4R,5S)-6-(Methylamino)hexane-1,2,3,4,5-pentaol hemi((3-(((2S,3R)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonate)
(2R,3R,4R,5S)-6-(Methylamino)hexane-1,2,3,4,5-pentaol hemi((3-(((2S,3R)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonate)
Catalogue No.:PA 06 0941000
CAS :
1523569-87-0
Molecular Formula : C37H56F7N6O16P
Molecular Weight : 1004.84
(3-(((2S,3R)-2-((R)-1-(3,5-bis(Trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic Acid
(3-(((2S,3R)-2-((R)-1-(3,5-bis(Trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic Acid
Catalogue No.:PA 06 0941001
CAS :
1185503-00-7
Molecular Formula : C23H22F7N4O6P
Molecular Weight : 614.41
(3-(((2R,3S)-2-((S)-1-(3,5-bis(Trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic Acid
(3-(((2R,3S)-2-((S)-1-(3,5-bis(Trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic Acid
Catalogue No.:PA 06 0941002
CAS :
NA
Molecular Formula : C23H22F7N4O6P
Molecular Weight : 614.41
(3-(((2R,3R)-2-((R)-1-(3,5-bis(Trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic Acid
(3-(((2R,3R)-2-((R)-1-(3,5-bis(Trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic Acid
Catalogue No.:PA 06 0941004
CAS :
1523569-89-2
Molecular Formula : C23H22F7N4O6P
Molecular Weight : 614.41
(3-(((2S,3S)-2-((S)-1-(3,5-bis(Trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic Acid
(3-(((2S,3S)-2-((S)-1-(3,5-bis(Trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic Acid
Catalogue No.:PA 06 0941005
CAS :
NA
Molecular Formula : C23H22F7N4O6P
Molecular Weight : 614.41
(2R,3R,4R,5S)-6-(Methylamino)hexane-1,2,3,4,5-pentaol hemi((3-(((2S,3S)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonate)
(2R,3R,4R,5S)-6-(Methylamino)hexane-1,2,3,4,5-pentaol hemi((3-(((2S,3S)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonate)
Catalogue No.:PA 06 0941006
CAS :
NA
Molecular Formula : C37H56F7N6O16P
Molecular Weight : 1004.84
(3-(((2R,3R)-2-((S)-1-(3,5-bis(Trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic Acid
(3-(((2R,3R)-2-((S)-1-(3,5-bis(Trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic Acid
Catalogue No.:PA 06 0941007
CAS :
NA
Molecular Formula : C23H22F7N4O6P
Molecular Weight : 614.41
(3-(((2S,3S)-2-((R)-1-(3,5-bis(Trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic Acid
(3-(((2S,3S)-2-((R)-1-(3,5-bis(Trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic Acid
Catalogue No.:PA 06 0941008
CAS :
172822-01-4
Molecular Formula : C23H22F7N4O6P
Molecular Weight : 614.41
(4-Benzyl-3-(((2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid
(4-Benzyl-3-(((2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid
Catalogue No.:PA 06 0941009
CAS :
2035475-10-4
Molecular Formula : C30H28F7N4O6P
Molecular Weight : 704.54
(4-Benzyl-3-(((2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid Dimeglumine Salt
(4-Benzyl-3-(((2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid Dimeglumine Salt
Catalogue No.:PA 06 0941010
CAS :
2035475-11-5
Molecular Formula : C44H62F7N6O16P
Molecular Weight : 1094.97
