gemcitabine and its Impurities
Gemcitabine is a nucleoside analog used as chemotherapy. It is marketed as Gemzar® by Eli Lilly and Company. Gemcitabine is used in various carcinomas: non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer. Reference standards of Gemcitabine API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


((2R,3R,5R)-3-(Benzoyloxy)-4,4-difluoro-5-((methylsulfonyl)oxy)tetrahydrofuran-2-yl)methyl benzoate
((2R,3R,5R)-3-(Benzoyloxy)-4,4-difluoro-5-((methylsulfonyl)oxy)tetrahydrofuran-2-yl)methyl benzoate
Catalogue No.:PA 07 0551003
CAS :
134877-42-2
Molecular Formula : C20H18F2O8S
Molecular Weight : 456.41


(2R,3R,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-4,4-difluoro-2-(hydroxymethyl)tetrahydrofuran-3-yl benzoate
(2R,3R,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-4,4-difluoro-2-(hydroxymethyl)tetrahydrofuran-3-yl benzoate
Catalogue No.:PA 07 0551006
CAS :
1147182-15-7
Molecular Formula : C16H15F2N3O5
Molecular Weight : 367.31