Gilteritinib and its Impurities
Gilteritinib, sold under the brand name Xospata, is an anti-cancer drug. It acts as an inhibitor of FLT3, hence it is a tyrosine kinase inhibitor.Gilteritinib has been repurposed as a potential antiviral drug as a possible application in the treatment of COVID-19. Reference standards of Gilteritinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
6-Ethyl-3-((3-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carbonitrile
6-Ethyl-3-((3-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carbonitrile
Catalogue No.:PA 07 0841000
CAS :
2043019-99-2
Molecular Formula : C29H42N8O2
Molecular Weight : 534.71
6-Ethyl-3-((3-methoxy-4-(4-(piperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carboxamide
6-Ethyl-3-((3-methoxy-4-(4-(piperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carboxamide
Catalogue No.:PA 07 0841001
CAS :
1373410-40-2
Molecular Formula : C28H42N8O3
Molecular Weight : 538.7
3-((4-(4-(4-(5-Carbamoyl-3-ethyl-6-((3-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrazin-2-yl)piperazin-1-yl)piperidin-1-yl)-3-methoxyphenyl)amino)-6-ethyl-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carboxamide
3-((4-(4-(4-(5-Carbamoyl-3-ethyl-6-((3-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrazin-2-yl)piperazin-1-yl)piperidin-1-yl)-3-methoxyphenyl)amino)-6-ethyl-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carboxamide
Catalogue No.:PA 07 0841005
CAS :
NA
Molecular Formula : C52H75N15O5
Molecular Weight : 990.27
6-Amino-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)pyridazine-3-carboxylic Acid
6-Amino-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)pyridazine-3-carboxylic Acid
Catalogue No.:PA 07 0841007
CAS :
3030727-66-0
Molecular Formula : C15H15N7O3
Molecular Weight : 341.33
