hydrocortisone and its Impurities
It is another term for cortisol hormone and is used as an immunosuppressive drug. Hydrocortisone is used as a medication for adrenocortical insufficiency and is used by mouth or as injection. Reference standards of Hydrocortisone API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


1-((8S,9S,10R,11S,13S,14S,17R)-11,17-Dihydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2,3-dihydroxy-4-((8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)butane-1,4-dione
1-((8S,9S,10R,11S,13S,14S,17R)-11,17-Dihydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2,3-dihydroxy-4-((8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)butane-1,4-dione
Catalogue No.:PA 08 13570
CAS :
NA
Molecular Formula : C42H58O9
Molecular Weight : 706.9


(8S,9S,10R,11S,13S,14S,17R)-11-Hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-3,6-dioxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl Pentanoate
(8S,9S,10R,11S,13S,14S,17R)-11-Hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-3,6-dioxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl Pentanoate
Catalogue No.:PA 08 13710
CAS :
NA
Molecular Formula : C26H36O7
Molecular Weight : 460.56


11,17-Dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
11,17-Dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
Catalogue No.:PA 08 14520
CAS :
NA
Molecular Formula : C21H30O5
Molecular Weight : 362.46


(8S,9S,10R,11R,13S,14S,17S)-17-(2,2-Dihydroxyacetyl)-11-hydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one
(8S,9S,10R,11R,13S,14S,17S)-17-(2,2-Dihydroxyacetyl)-11-hydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one
Catalogue No.:PA 08 13800
CAS :
NA
Molecular Formula : C21H30O5
Molecular Weight : 362.47


2-((1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)amino)-2-((8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)acetic Acid
2-((1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)amino)-2-((8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)acetic Acid
Catalogue No.:PA 08 13840
CAS :
NA
Molecular Formula : C25H39NO7
Molecular Weight : 465.59


(8S,9S,10R,11S,13S,14S,17R)-11-Hydroxy-10,13-dimethyl-1,8,9,10,11,12,13,14,15,16-decahydrodispiro[cyclopenta[a]phenanthrene-17,4'-[1,3]dioxolane-5',4''-[1,3]dioxolan]-3(2H)-one
(8S,9S,10R,11S,13S,14S,17R)-11-Hydroxy-10,13-dimethyl-1,8,9,10,11,12,13,14,15,16-decahydrodispiro[cyclopenta[a]phenanthrene-17,4'-[1,3]dioxolane-5',4''-[1,3]dioxolan]-3(2H)-one
Catalogue No.:PAI 08 005050
CAS :
NA
Molecular Formula : C23H30O6
Molecular Weight : 402.49


(8S,9S,10R,11S,13S,14S,17R)-3-Ethoxy-10,13-dimethyl-1,2,7,8,9,10,11,12,13,14,15,16-dodecahydrodispiro[cyclopenta[a]phenanthrene-17,4'-[1,3]dioxolane-5',4''-[1,3]dioxolan]-11-ol
(8S,9S,10R,11S,13S,14S,17R)-3-Ethoxy-10,13-dimethyl-1,2,7,8,9,10,11,12,13,14,15,16-dodecahydrodispiro[cyclopenta[a]phenanthrene-17,4'-[1,3]dioxolane-5',4''-[1,3]dioxolan]-11-ol
Catalogue No.:PAI 08 005060
CAS :
NA
Molecular Formula : C25H36O6
Molecular Weight : 432.56


(8S,9S,10R,11S,13S,14S,17R)-3-ethoxy-10,13-dimethyl-1,2,7,8,9,10,11,12,13,14,15,16-dodecahydrodispiro[cyclopenta[a]phenanthrene-17,4'-[1,3]dioxolane-5',4''-[1,3]dioxolane]-6,11-diol
(8S,9S,10R,11S,13S,14S,17R)-3-ethoxy-10,13-dimethyl-1,2,7,8,9,10,11,12,13,14,15,16-dodecahydrodispiro[cyclopenta[a]phenanthrene-17,4'-[1,3]dioxolane-5',4''-[1,3]dioxolane]-6,11-diol
Catalogue No.:PAI 08 005070
CAS :
NA
Molecular Formula : C25H36O7
Molecular Weight : 448.56


(8S,9S,10R,11S,13S,14S,17R)-11-Hydroxy-3-methoxy-5',5',10,13-tetramethyl-1,2,4',5',7,8,9,10,11,12,13,14,15,16-tetradecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3'-one
(8S,9S,10R,11S,13S,14S,17R)-11-Hydroxy-3-methoxy-5',5',10,13-tetramethyl-1,2,4',5',7,8,9,10,11,12,13,14,15,16-tetradecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3'-one
Catalogue No.:PAI 08 005080
CAS :
NA
Molecular Formula : C25H36O4
Molecular Weight : 400.56


(6R,8S,9S,10R,11S,13S,14S,17R)-6,11-Dihydroxy-5',5',10,13-tetramethyl-1,4',5',6,7,8,9,10,11,12,13,14,15,16-tetradecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,3'(2H)-dione
(6R,8S,9S,10R,11S,13S,14S,17R)-6,11-Dihydroxy-5',5',10,13-tetramethyl-1,4',5',6,7,8,9,10,11,12,13,14,15,16-tetradecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,3'(2H)-dione
Catalogue No.:PAI 08 005090
CAS :
NA
Molecular Formula : C24H34O5
Molecular Weight : 402.53


(8S,9S,10R,11S,13S,14S,17R)-11-Hydroxy-3-methoxy-2',2',10,13-tetramethyl-1,2,7,8,9,10,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-17,4'-[1,3]dioxan]-5'-one
(8S,9S,10R,11S,13S,14S,17R)-11-Hydroxy-3-methoxy-2',2',10,13-tetramethyl-1,2,7,8,9,10,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-17,4'-[1,3]dioxan]-5'-one
Catalogue No.:PAI 08 005100
CAS :
NA
Molecular Formula : C25H36O5
Molecular Weight : 416.56


(6R,8S,9S,10R,11S,13S,14S,17R)-6,11-Dihydroxy-2',2',10,13-tetramethyl-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-17,4'-[1,3]dioxane]-3,5'(2H)-dione
(6R,8S,9S,10R,11S,13S,14S,17R)-6,11-Dihydroxy-2',2',10,13-tetramethyl-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-17,4'-[1,3]dioxane]-3,5'(2H)-dione
Catalogue No.:PAI 08 005110
CAS :
NA
Molecular Formula : C24H34O6
Molecular Weight : 418.53


(8S,9S,10R,11R,13S,14S,17R)-17-(2-Acetoxyacetyl)-17-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-11-yl 4-nitrobenzoate
(8S,9S,10R,11R,13S,14S,17R)-17-(2-Acetoxyacetyl)-17-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-11-yl 4-nitrobenzoate
Catalogue No.:PAI 08 005120
CAS :
NA
Molecular Formula : C30H35NO9
Molecular Weight : 553.61


2-((8S,9S,10R,11S,13S,14S,17R)-17-Hydroxy-10,13-dimethyl-3-oxo-11-(tosyloxy)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl Acetate
2-((8S,9S,10R,11S,13S,14S,17R)-17-Hydroxy-10,13-dimethyl-3-oxo-11-(tosyloxy)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl Acetate
Catalogue No.:PAI 08 005130
CAS :
NA
Molecular Formula : C30H38O8S
Molecular Weight : 558.69


2-((8S,9S,10R,11R,13S,14S,17R)-11-Acetoxy-17-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl Acetate
2-((8S,9S,10R,11R,13S,14S,17R)-11-Acetoxy-17-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl Acetate
Catalogue No.:PAI 08 005140
CAS :
NA
Molecular Formula : C25H34O7
Molecular Weight : 446.54


(8S,9S,10R,11S,13S,14S,17R)-3-methoxy-2',2',10,13-tetramethyl-5'-oxo-1,2,7,8,9,10,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-17,4'-[1,3]dioxan]-11-yl 4-methylbenzenesulfonate
(8S,9S,10R,11S,13S,14S,17R)-3-methoxy-2',2',10,13-tetramethyl-5'-oxo-1,2,7,8,9,10,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-17,4'-[1,3]dioxan]-11-yl 4-methylbenzenesulfonate
Catalogue No.:PAI 08 005150
CAS :
NA
Molecular Formula : C32H42O7S
Molecular Weight : 570.74