ibrutinib and its Impurities
Ibrutinib is used to treat chronic lymphocytic leukemia Waldenström's macroglobulinemia, and as a second-line treatment for mantle cell lymphoma, marginal zone lymphoma, and chronic graft vs host disease. It is a small molecule drug. Reference standards of Ibrutinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
1-((R)-3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2-chloropropan-1-one
1-((R)-3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2-chloropropan-1-one
Catalogue No.:PA 09 0271054
CAS :
1906970-58-8
Molecular Formula : C25H25ClN6O2
Molecular Weight : 476.97
N-(1-((R)-1-Acryloylpiperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-N-(3-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3-oxopropyl)nitrous amide
N-(1-((R)-1-Acryloylpiperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-N-(3-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3-oxopropyl)nitrous amide
Catalogue No.:PA 09 0271052
CAS :
NA
Molecular Formula : C50H47N13O5
Molecular Weight : 910.01
((S)-3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)(1-((R)-1-nitrosopiperidin-3-yl)-2a-(4-phenoxyphenyl)-1,2,2a,3,4,5-hexahydro-1,2,5,6,8-pentaazaacenaphthylen-4-yl)methanone
((S)-3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)(1-((R)-1-nitrosopiperidin-3-yl)-2a-(4-phenoxyphenyl)-1,2,2a,3,4,5-hexahydro-1,2,5,6,8-pentaazaacenaphthylen-4-yl)methanone
Catalogue No.:PA 09 0271055
CAS :
NA
Molecular Formula : C47H45N13O4
Molecular Weight : 855.96
tert-Butyl (R)-3-(3-(4-phenoxyphenyl)-4-((triphenyl-l5-phosphaneylidene)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
tert-Butyl (R)-3-(3-(4-phenoxyphenyl)-4-((triphenyl-l5-phosphaneylidene)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
Catalogue No.:PA 09 0271056
CAS :
2064175-42-2
Molecular Formula : C45H43N6O3P
Molecular Weight : 746.85
