ivabradine and its Impurities
Ivabradine is used for the symptomatic treatment of chronic stable angina pectoris in patients with normal sinus rhythm who cannot take beta blockers. It is marketed under the trade name Corlanor. Reference standards of Ivabradine API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
 
	
			                                  ![3-(3-((((S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5- PA 09 0581000](https://www.pharmaffiliates.com/pimages/PA090581000.jpg) 
																				3-(3-((((S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepine 3-Oxide
3-(3-((((S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepine 3-Oxide
- Catalogue No.:PA 09 0581000 
- CAS : - NA
- Molecular Formula : C27H36N2O6 
- Molecular Weight : 484.59 
 
	
			                                  ![(S)-3-(3-(((3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2 PA 09 0581001](https://www.pharmaffiliates.com/pimages/PA090581001.jpg) 
																				(S)-3-(3-(((3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepine-1,2(3H)-dione Oxalate
(S)-3-(3-(((3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepine-1,2(3H)-dione Oxalate
- Catalogue No.:PA 09 0581001 
- CAS : - NA
- Molecular Formula : C29H36N2O10 
- Molecular Weight : 572.61 
 
	
			                                   
																				3-(3-((((1R,3S,4R,6S,7S)-3,4-Dimethoxybicyclo[4.2.0]octan-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one
3-(3-((((1R,3S,4R,6S,7S)-3,4-Dimethoxybicyclo[4.2.0]octan-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one
- Catalogue No.:PA 09 0581005 
- CAS : - NA
- Molecular Formula : C27H42N2O5 
- Molecular Weight : 474.64 
 
	
			                                   
																				3-(3-((((1S,3R,4S,6R,7S)-3,4-Dimethoxybicyclo[4.2.0]octan-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one
3-(3-((((1S,3R,4S,6R,7S)-3,4-Dimethoxybicyclo[4.2.0]octan-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one
- Catalogue No.:PA 09 0581006 
- CAS : - NA
- Molecular Formula : C27H42N2O5 
- Molecular Weight : 474.64 
 
	
			                                  ![3-(3-((((S)-3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2 PA 09 0581007](https://www.pharmaffiliates.com/pimages/PA090581007.jpg) 
																				3-(3-((((S)-3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-5-hydroxy-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one
3-(3-((((S)-3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-5-hydroxy-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one
- Catalogue No.:PA 09 0581007 
- CAS : - 2253977-80-7
- Molecular Formula : C27H36N2O6 
- Molecular Weight : 484.59 
 
	
			                                   
																				3-(3-((3-Chloro-2-(3,4-dimethoxyphenyl)propyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one
3-(3-((3-Chloro-2-(3,4-dimethoxyphenyl)propyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one
- Catalogue No.:PA 09 0581008 
- CAS : - NA
- Molecular Formula : C27H37ClN2O5 
- Molecular Weight : 505.05 
 
	
			                                   
																				3-(2,3-Dimethoxy-6-oxo-6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl)-N-(((S)-3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)-N-methylpropan-1-amine oxide
3-(2,3-Dimethoxy-6-oxo-6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl)-N-(((S)-3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)-N-methylpropan-1-amine oxide
- Catalogue No.:PA 09 0581010 
- CAS : - NA
- Molecular Formula : C28H37NO6 
- Molecular Weight : 483.61 
 
	
			                                  ![3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trie PA 09 0581011](https://www.pharmaffiliates.com/pimages/PA090581011.jpg) 
																				3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one hydrochloride
3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one hydrochloride
- Catalogue No.:PA 09 0581011 
- CAS : - 1796933-38-4
- Molecular Formula : C27H37ClN2O5 
- Molecular Weight : 505.05 
 
	
			                                  ![1-(((S)-3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2,4-t PA 09 0581015](https://www.pharmaffiliates.com/pimages/PA090581015.jpg) 
																				1-(((S)-3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)-3-(((S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)urea
1-(((S)-3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)-3-(((S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)urea
- Catalogue No.:PA 09 0581015 
- CAS : - NA
- Molecular Formula : C23H28N2O5 
- Molecular Weight : 412.49 
 
	
			                                  ![(R)-3-(3-(((3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2 PA 09 0581019](https://www.pharmaffiliates.com/pimages/PA090581019.jpg) 
																				(R)-3-(3-(((3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one
(R)-3-(3-(((3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one
- Catalogue No.:PA 09 0581019 
- CAS : - 2724918-59-4
- Molecular Formula : C26H34N2O5 
- Molecular Weight : 454.57 
 
	
			                                  ![3-(3-((((S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5- PA 09 0581020](https://www.pharmaffiliates.com/pimages/PA090581020.jpg) 
																				3-(3-((((S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxydecahydro-2H-benzo[d]azepin-2-one Hydrochloride
3-(3-((((S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxydecahydro-2H-benzo[d]azepin-2-one Hydrochloride
- Catalogue No.:PA 09 0581020 
- CAS : - NA
- Molecular Formula : C27H43ClN2O5 
- Molecular Weight : 511.1 
 
	
			                                  ![(S)-3-(3-(((3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5- PA 09 0581021](https://www.pharmaffiliates.com/pimages/PA090581021.jpg) 
																				(S)-3-(3-(((3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,5-dihydro-2H-benzo[d]azepine-2,4(3H)-dione
(S)-3-(3-(((3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,5-dihydro-2H-benzo[d]azepine-2,4(3H)-dione
- Catalogue No.:PA 09 0581021 
- CAS : - 1629315-02-1
- Molecular Formula : C27H34N2O6 
- Molecular Weight : 482.58 
 
	
			                                  ![(S)-3-Chloro-N-((3,4-dimethoxybicyclo[4.2.0]octa-1 PA 09 0581022](https://www.pharmaffiliates.com/pimages/PA090581022.jpg) 
																				(S)-3-Chloro-N-((3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)-N-methylpropan-1-amine
(S)-3-Chloro-N-((3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)-N-methylpropan-1-amine
- Catalogue No.:PA 09 0581022 
- CAS : - 1031767-71-1
- Molecular Formula : C15H22ClNO2 
- Molecular Weight : 283.8 
 
	
			                                  ![3-(3-((((S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5- PA 09 0581025](https://www.pharmaffiliates.com/pimages/PA090581025.jpg) 
																				3-(3-((((S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-1-hydroxy-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one
3-(3-((((S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-1-hydroxy-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one
- Catalogue No.:PA 09 0581025 
- CAS : - 2511244-96-3
- Molecular Formula : C27H36N2O6 
- Molecular Weight : 484.59 
 
	
			                                  ![3-(3-(((4-Hydroxy-3-methoxybicyclo[4.2.0]octa-1,3, PA 09 0581024](https://www.pharmaffiliates.com/pimages/PA090581024.jpg) 
																				3-(3-(((4-Hydroxy-3-methoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one
3-(3-(((4-Hydroxy-3-methoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one
- Catalogue No.:PA 09 0581024 
- CAS : - 2247881-27-0
- Molecular Formula : C26H34N2O5 
- Molecular Weight : 454.57 
 
	
			                                  ![(S)-3-(3-(((4-Hydroxy-3-methoxybicyclo[4.2.0]octa- PA 09 0581026](https://www.pharmaffiliates.com/pimages/PA090581026.jpg) 
																				(S)-3-(3-(((4-Hydroxy-3-methoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one
(S)-3-(3-(((4-Hydroxy-3-methoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one
- Catalogue No.:PA 09 0581026 
- CAS : - 304465-03-0
- Molecular Formula : C26H34N2O5 
- Molecular Weight : 454.57 
 
	
			                                  ![(S)-3-(3-(((3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2 PA 09 0581029](https://www.pharmaffiliates.com/pimages/PA090581029.jpg) 
																				(S)-3-(3-(((3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-5-hydroxy-7,8-dimethoxy-1,3-dihydro-2H-benzo[d]azepin-2-one
(S)-3-(3-(((3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-5-hydroxy-7,8-dimethoxy-1,3-dihydro-2H-benzo[d]azepin-2-one
- Catalogue No.:PA 09 0581029 
- CAS : - NA
- Molecular Formula : C27H34N2O6 
- Molecular Weight : 482.58 
 
	
			                                  ![(R)-3-(3-(((3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2 PA 09 0581032](https://www.pharmaffiliates.com/pimages/PA090581032.jpg) 
																				(R)-3-(3-(((3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-2,3-dihydro-1H-benzo[d]azepine-1,4(5H)-dione
(R)-3-(3-(((3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-2,3-dihydro-1H-benzo[d]azepine-1,4(5H)-dione
- Catalogue No.:PA 09 0581032 
- CAS : - NA
- Molecular Formula : C27H34N2O6 
- Molecular Weight : 482.58 
 
	
			                                  ![(S)-3-(3-(((3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5- PA STI 089846](https://www.pharmaffiliates.com/pimages/PASTI089846.jpg) 
																				(S)-3-(3-(((3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-bis(methoxy-d3)-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one Hydrochloride
(S)-3-(3-(((3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-bis(methoxy-d3)-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one Hydrochloride
- Catalogue No.:PA STI 089846 
- CAS : - 2070009-63-9
- Molecular Formula : C27H31D6ClN2O5 
- Molecular Weight : 511.09 
 
	
			                                   
																				3-(3-((2-Chloro-3-(3,4-dimethoxyphenyl)propyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one
3-(3-((2-Chloro-3-(3,4-dimethoxyphenyl)propyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one
- Catalogue No.:PA 09 0581039 
- CAS : - 2373259-08-4
- Molecular Formula : C27H37ClN2O5 
- Molecular Weight : 505.05 

 
																				 
																				 
																				 
																				 
																				![[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien PA 09 0581002](https://www.pharmaffiliates.com/pimages/PA090581002.jpg) 
																				![N-((3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7- PA 09 0581003](https://www.pharmaffiliates.com/pimages/PA090581003.jpg) 
																				![Ethyl (E)-N-((3,4-dimethoxybicyclo[4.2.0]octa-1,3, PA 09 0581004](https://www.pharmaffiliates.com/pimages/PA090581004.jpg) 
																				 
																				 
																				![4,5-Dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-car PA 09 0581013](https://www.pharmaffiliates.com/pimages/PA090581013.jpg) 
																				 
																				 
																				 
																				![(S)-N-((3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trie PA 09 0581018](https://www.pharmaffiliates.com/pimages/PA090581018.jpg) 
																				 
																				 
																				![(S)-N-((3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2,4-t PA 09 0581028](https://www.pharmaffiliates.com/pimages/PA090581028.jpg) 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				![3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-car PA 09 0581038](https://www.pharmaffiliates.com/pimages/PA090581038.jpg) 
																				 
 
 
 
