Larotrectinib and its Impurities

Larotrectinib (tradename Vitrakvi) is a drug for the treatment of cancer.It is an inhibitor of tropomyosin kinase receptors TrkA, TrkB, and TrkC. It was discovered by Array BioPharma and licensed to Loxo Oncology in 2013. Reference standards of Larotrectinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

Displaying 12 results for Larotrectinib Impurities
PA 12 1480000

Larotrectinib

Larotrectinib

  • Catalogue No.:PA 12 1480000

  • CAS :

    1223403-58-4

  • Molecular Formula : C21H22F2N6O2

  • Molecular Weight : 428.44

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PA 12 1481000

(S)-N-(5-Chloropyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide

(S)-N-(5-Chloropyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide

  • Catalogue No.:PA 12 1481000

  • CAS :

    2226370-52-9

  • Molecular Formula : C11H12ClN5O2

  • Molecular Weight : 281.7

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PA 12 1481002

(S)-1-benzyl-3-hydroxypyrrolidine-2,5-dione

(S)-1-benzyl-3-hydroxypyrrolidine-2,5-dione

  • Catalogue No.:PA 12 1481002

  • CAS :

    101469-91-4

  • Molecular Formula : C11H11NO3

  • Molecular Weight : 205.21

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PA 12 1481001

(S)-1-benzylpyrrolidin-3-ol

(S)-1-benzylpyrrolidin-3-ol

  • Catalogue No.:PA 12 1481001

  • CAS :

    101385-90-4

  • Molecular Formula : C11H15NO

  • Molecular Weight : 177.25

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PA 12 1481003

Larotrectinib Open-Ring Dimer

Larotrectinib Open-Ring Dimer

  • Catalogue No.:PA 12 1481003

  • CAS :

    NA

  • Molecular Formula : C25H31F2N7O3

  • Molecular Weight : 515.57

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PA 12 1481004

1-(4-Bromo-3-fluorophenyl)ethan-1-one

1-(4-Bromo-3-fluorophenyl)ethan-1-one

  • Catalogue No.:PA 12 1481004

  • CAS :

    304445-49-6

  • Molecular Formula : C8H6BrFO

  • Molecular Weight : 217.04

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PA 12 1481005

4-Acetyl-2-fluorobenzonitrile

4-Acetyl-2-fluorobenzonitrile

  • Catalogue No.:PA 12 1481005

  • CAS :

    214760-18-6

  • Molecular Formula : C9H6FNO

  • Molecular Weight : 163.15

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PA 12 1481006

(R)-5-(2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine

(R)-5-(2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine

  • Catalogue No.:PA 12 1481006

  • CAS :

    1223404-88-3

  • Molecular Formula : C16H15F2N5

  • Molecular Weight : 315.33

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PA 12 1481007

1,3-Bis(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)urea

1,3-Bis(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)urea

  • Catalogue No.:PA 12 1481007

  • CAS :

    NA

  • Molecular Formula : C33H28F4N10O

  • Molecular Weight : 656.65

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PA 12 1481008

(R)-N-(5-(2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-2,3-dihydro-1H-pyrrole-1-carboxamide

(R)-N-(5-(2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-2,3-dihydro-1H-pyrrole-1-carboxamide

  • Catalogue No.:PA 12 1481008

  • CAS :

    NA

  • Molecular Formula : C21H20F2N6O

  • Molecular Weight : 410.43

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PA 12 1481009

(R)-N-(5-(2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-2,3-dihydro-1H-pyrrole-1-carboxamide

(R)-N-(5-(2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-oxopyrrolidine-1-carboxamide

  • Catalogue No.:PA 12 1481009

  • CAS :

    2699151-02-3

  • Molecular Formula : C21H20F2N6O2

  • Molecular Weight : 426.43

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PA 12 1481010

(2R)-2-(2,5-Difluorophenyl)-1-(3-((S)-3-hydroxypyrrolidine-1-carboxamido)pyrazolo[1,5-a]pyrimidin-5-yl)pyrrolidine 1-oxide

(2R)-2-(2,5-Difluorophenyl)-1-(3-((S)-3-hydroxypyrrolidine-1-carboxamido)pyrazolo[1,5-a]pyrimidin-5-yl)pyrrolidine 1-oxide

  • Catalogue No.:PA 12 1481010

  • CAS :

    NA

  • Molecular Formula : C21H22F2N6O3

  • Molecular Weight : 444.44

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