Larotrectinib and its Impurities

Larotrectinib (tradename Vitrakvi) is a drug for the treatment of cancer.It is an inhibitor of tropomyosin kinase receptors TrkA, TrkB, and TrkC. It was discovered by Array BioPharma and licensed to Loxo Oncology in 2013. Reference standards of Larotrectinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

Displaying 14 results for Larotrectinib Impurities
Drug Reference Standards & Impurity Synthesis in India
PA 12 1480000

Larotrectinib

Larotrectinib

  • Catalogue No.:PA 12 1480000

  • CAS :

    1223403-58-4

  • Molecular Formula : C21H22F2N6O2

  • Molecular Weight : 428.44

Enquire
Details
Drug Reference Standards & Impurity Synthesis in India
PA 12 1481000

(S)-N-(5-Chloropyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide

(S)-N-(5-Chloropyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide

  • Catalogue No.:PA 12 1481000

  • CAS :

    2226370-52-9

  • Molecular Formula : C11H12ClN5O2

  • Molecular Weight : 281.7

Enquire
Details
Drug Reference Standards & Impurity Synthesis in India
PA 12 1481002

(S)-1-benzyl-3-hydroxypyrrolidine-2,5-dione

(S)-1-benzyl-3-hydroxypyrrolidine-2,5-dione

  • Catalogue No.:PA 12 1481002

  • CAS :

    101469-91-4

  • Molecular Formula : C11H11NO3

  • Molecular Weight : 205.21

Enquire
Details
Drug Reference Standards & Impurity Synthesis in India
PA 12 1481001

(S)-1-benzylpyrrolidin-3-ol

(S)-1-benzylpyrrolidin-3-ol

  • Catalogue No.:PA 12 1481001

  • CAS :

    101385-90-4

  • Molecular Formula : C11H15NO

  • Molecular Weight : 177.25

Enquire
Details
Drug Reference Standards & Impurity Synthesis in India
PA 12 1481003

Larotrectinib Open-Ring Dimer

Larotrectinib Open-Ring Dimer

  • Catalogue No.:PA 12 1481003

  • CAS :

    NA

  • Molecular Formula : C25H31F2N7O3

  • Molecular Weight : 515.57

Enquire
Details
Drug Reference Standards & Impurity Synthesis in India
PA 12 1481004

1-(4-Bromo-3-fluorophenyl)ethan-1-one

1-(4-Bromo-3-fluorophenyl)ethan-1-one

  • Catalogue No.:PA 12 1481004

  • CAS :

    304445-49-6

  • Molecular Formula : C8H6BrFO

  • Molecular Weight : 217.04

Enquire
Details
Drug Reference Standards & Impurity Synthesis in India
PA 12 1481005

4-Acetyl-2-fluorobenzonitrile

4-Acetyl-2-fluorobenzonitrile

  • Catalogue No.:PA 12 1481005

  • CAS :

    214760-18-6

  • Molecular Formula : C9H6FNO

  • Molecular Weight : 163.15

Enquire
Details
Drug Reference Standards & Impurity Synthesis in India
PA 12 1481006

(R)-5-(2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine

(R)-5-(2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine

  • Catalogue No.:PA 12 1481006

  • CAS :

    1223404-88-3

  • Molecular Formula : C16H15F2N5

  • Molecular Weight : 315.33

Enquire
Details
Drug Reference Standards & Impurity Synthesis in India
PA 12 1481007

1,3-Bis(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)urea

1,3-Bis(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)urea

  • Catalogue No.:PA 12 1481007

  • CAS :

    NA

  • Molecular Formula : C33H28F4N10O

  • Molecular Weight : 656.65

Enquire
Details
Drug Reference Standards & Impurity Synthesis in India
PA 12 1481008

(R)-N-(5-(2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-2,3-dihydro-1H-pyrrole-1-carboxamide

(R)-N-(5-(2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-2,3-dihydro-1H-pyrrole-1-carboxamide

  • Catalogue No.:PA 12 1481008

  • CAS :

    NA

  • Molecular Formula : C21H20F2N6O

  • Molecular Weight : 410.43

Enquire
Details
Drug Reference Standards & Impurity Synthesis in India
PA 12 1481009

(R)-N-(5-(2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-2,3-dihydro-1H-pyrrole-1-carboxamide

(R)-N-(5-(2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-oxopyrrolidine-1-carboxamide

  • Catalogue No.:PA 12 1481009

  • CAS :

    2699151-02-3

  • Molecular Formula : C21H20F2N6O2

  • Molecular Weight : 426.43

Enquire
Details
Drug Reference Standards & Impurity Synthesis in India
PA 12 1481010

(2R)-2-(2,5-Difluorophenyl)-1-(3-((S)-3-hydroxypyrrolidine-1-carboxamido)pyrazolo[1,5-a]pyrimidin-5-yl)pyrrolidine 1-oxide

(2R)-2-(2,5-Difluorophenyl)-1-(3-((S)-3-hydroxypyrrolidine-1-carboxamido)pyrazolo[1,5-a]pyrimidin-5-yl)pyrrolidine 1-oxide

  • Catalogue No.:PA 12 1481010

  • CAS :

    NA

  • Molecular Formula : C21H22F2N6O3

  • Molecular Weight : 444.44

Enquire
Details
Drug Reference Standards & Impurity Synthesis in India
PA 12 1481011

(R)-2-(2,5-Difluorophenyl)-1-nitrosopyrrolidine

(R)-2-(2,5-Difluorophenyl)-1-nitrosopyrrolidine

  • Catalogue No.:PA 12 1481011

  • CAS :

    NA

  • Molecular Formula : C10H10F2N2O

  • Molecular Weight : 212.2

Enquire
Details
Drug Reference Standards & Impurity Synthesis in India
PA 12 1481012

(S)-N-(5-((R)-2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxy-N-nitrosopyrrolidine-1-carboxamide

(S)-N-(5-((R)-2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxy-N-nitrosopyrrolidine-1-carboxamide

  • Catalogue No.:PA 12 1481012

  • CAS :

    NA

  • Molecular Formula : C21H21F2N7O3

  • Molecular Weight : 457.44

Enquire
Details
Periodic Table- Pharmaffiliates

Calculators
Periodic Table- Pharmaffiliates

Contact us

Ask A Scientist-Pharmaffiliates

Ask a Scientist
General Help

General Help
pharmaffiliates