Lazertinib and its Impurities
Lazertinib, brand name - Lazcluze is a third-generation EGFR tyrosine kinase inhibitor (TKI) used in the treatment of non-small cell lung cancer (NSCLC) with specific EGFR mutations. Reference standards of Lazertinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
4-(2-Acrylamido-4-((4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidin-2-yl)amino)-5-methoxyphenyl)morpholine 4-oxide
4-(2-Acrylamido-4-((4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidin-2-yl)amino)-5-methoxyphenyl)morpholine 4-oxide
Catalogue No.:PA 12 2201000
CAS :
NA
Molecular Formula : C30H34N8O4
Molecular Weight : 570.65
N-(5-((4-(4-((Dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidin-2-yl)amino)-4-hydroxy-2-morpholinophenyl)acrylamide
N-(5-((4-(4-((Dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidin-2-yl)amino)-4-hydroxy-2-morpholinophenyl)acrylamide
Catalogue No.:PA 12 2201001
CAS :
NA
Molecular Formula : C29H32N8O3
Molecular Weight : 540.63
N-(5-((4-(4-((Dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidin-2-yl)amino)-4-methoxy-2-morpholinophenyl)-4-hydroxybutanamide
N-(5-((4-(4-((Dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidin-2-yl)amino)-4-methoxy-2-morpholinophenyl)-4-hydroxybutanamide
Catalogue No.:PA 12 2201002
CAS :
NA
Molecular Formula : C31H38N8O4
Molecular Weight : 586.7
N-(4-Methoxy-5-((4-(4-((methyl(nitroso)amino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidin-2-yl)amino)-2-morpholinophenyl)acrylamide
N-(4-Methoxy-5-((4-(4-((methyl(nitroso)amino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidin-2-yl)amino)-2-morpholinophenyl)acrylamide
Catalogue No.:PA 12 2201003
CAS :
NA
Molecular Formula : C29H31N9O4
Molecular Weight : 569.63
N-(5-((4-(4-((Dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidin-2-yl)(nitroso)amino)-4-methoxy-2-morpholinophenyl)acrylamide
N-(5-((4-(4-((Dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidin-2-yl)(nitroso)amino)-4-methoxy-2-morpholinophenyl)acrylamide
Catalogue No.:PA 12 2201004
CAS :
NA
Molecular Formula : C30H33N9O4
Molecular Weight : 583.65
3-Chloro-N-(5-((4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidin-2-yl)amino)-4-methoxy-2-morpholinophenyl)propanamide
3-Chloro-N-(5-((4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidin-2-yl)amino)-4-methoxy-2-morpholinophenyl)propanamide
Catalogue No.:PA 12 2201005
CAS :
NA
Molecular Formula : C30H35ClN8O3
Molecular Weight : 591.11
N-((1-(2-((5-Acrylamido-2-methoxy-4-morpholinophenyl)amino)pyrimidin-4-yl)-3-phenyl-1H-pyrazol-4-yl)methyl)-3-((5-((4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidin-2-yl)amino)-4-methoxy-2-morpholinophenyl)amino)-N,N-dimethyl-3-oxopropan-1-aminium Chloride
N-((1-(2-((5-Acrylamido-2-methoxy-4-morpholinophenyl)amino)pyrimidin-4-yl)-3-phenyl-1H-pyrazol-4-yl)methyl)-3-((5-((4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidin-2-yl)amino)-4-methoxy-2-morpholinophenyl)amino)-N,N-dimethyl-3-oxopropan-1-aminium Chloride
Catalogue No.:PA 12 2201006
CAS :
NA
Molecular Formula : C60H69ClN16O6
Molecular Weight : 1145.77
1-(2-((2-Methoxy-4-morpholino-5-nitrophenyl)amino)pyrimidin-4-yl)-5-phenyl-1H-pyrazole-4-carbaldehyde
1-(2-((2-Methoxy-4-morpholino-5-nitrophenyl)amino)pyrimidin-4-yl)-5-phenyl-1H-pyrazole-4-carbaldehyde
Catalogue No.:PA 12 2201007
CAS :
NA
Molecular Formula : C25H23N7O5
Molecular Weight : 501.5
