levosimendan and its Impurities
Levosimendan is marketed under the trade name Simdax. It is a calcium sensitiser used in the management of acutely decompensated congestive heart failure. Reference standards of Levosimendan API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


2-[2-[4-(2-Azidotetrahydro-3-methyl-5-oxo-2-furanyl)phenyl]hydrazinylidene]propanedinitrile
2-[2-[4-(2-Azidotetrahydro-3-methyl-5-oxo-2-furanyl)phenyl]hydrazinylidene]propanedinitrile
Catalogue No.:PA 12 42510
CAS :
252638-01-0
Molecular Formula : C14H11N7O2
Molecular Weight : 309.28


4-Amino-6-ethoxy-N-(4-((R)-4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)-5-((4-((R)-4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)diazenyl)pyrimidine-2-carbohydrazonoyl cyanide
4-Amino-6-ethoxy-N-(4-((R)-4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)-5-((4-((R)-4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)diazenyl)pyrimidine-2-carbohydrazonoyl cyanide
Catalogue No.:PA 12 42560
CAS :
618458-79-0
Molecular Formula : C30H30N12O3
Molecular Weight : 606.65


2-Amino-N-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)-2-oxoacetohydrazonoyl Cyanide
2-Amino-N-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)-2-oxoacetohydrazonoyl Cyanide
Catalogue No.:PA 12 42580
CAS :
131741-37-2
Molecular Formula : C14H14N6O2
Molecular Weight : 298.31


(E)-2-(4-((E)-Isocyano(2-(4-((R)-4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)hydrazono)methyl)-2H-1,3-oxazet-2-ylidene)-2-((E)-(4-((R)-4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)diazenyl)acetonitrile
(E)-2-(4-((E)-Isocyano(2-(4-((R)-4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)hydrazono)methyl)-2H-1,3-oxazet-2-ylidene)-2-((E)-(4-((R)-4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)diazenyl)acetonitrile
Catalogue No.:PA 12 0421002
CAS :
NA
Molecular Formula : C28H23N11O3
Molecular Weight : 561.57


(R,Z)-2-Amino-N-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)-2-oxoacetohydrazonoyl cyanide
(R,Z)-2-Amino-N-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)-2-oxoacetohydrazonoyl cyanide
Catalogue No.:PA 12 0421003
CAS :
NA
Molecular Formula : C14H14N6O2
Molecular Weight : 298.31


Methyl (R,E)-2-cyano-2-(2-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)hydrazono)acetate
Methyl (R,E)-2-cyano-2-(2-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)hydrazono)acetate
Catalogue No.:PA 12 0421006
CAS :
NA
Molecular Formula : C15H15N5O3
Molecular Weight : 313.32


(R)-N'-(Dicyanomethylene)-N-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)nitrous Hydrazide
(R)-N'-(Dicyanomethylene)-N-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)nitrous Hydrazide
Catalogue No.:PA 12 0421007
CAS :
NA
Molecular Formula : C14H11N7O2
Molecular Weight : 309.29


(R,E)-2-Amino-N-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)-2-oxoacetohydrazonoyl Cyanide
(R,E)-2-Amino-N-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)-2-oxoacetohydrazonoyl Cyanide
Catalogue No.:PA 12 0421008
CAS :
2493974-39-1
Molecular Formula : C14H14N6O2
Molecular Weight : 298.31