levothyroxine and its Impurities
A synthetic form of thyroid hormone, Thyroxine. Levothyroxine is used in the treatment of thyroid hormone deficiency and certain types of thyroid tumors. It is a levorotatory enantiomer of Thyroxine. Reference standards of Levothyroxine API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


(S)-2-((tert-Butoxycarbonyl)amino)-3-(4-(4-((4-hydroxycyclohexa-1,3-dien-1-yl)oxy)-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoic Acid
(S)-2-((tert-Butoxycarbonyl)amino)-3-(4-(4-((4-hydroxycyclohexa-1,3-dien-1-yl)oxy)-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoic Acid
Catalogue No.:PAI 12 008264
CAS :
NA
Molecular Formula : C26H25I4NO7
Molecular Weight : 971.1


Methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-((tert-butyldimethylsilyl)oxy)phenoxy)-3-chloro-5-iodophenyl)propanoate
Methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-((tert-butyldimethylsilyl)oxy)phenoxy)-3-chloro-5-iodophenyl)propanoate
Catalogue No.:PAI 12 008267
CAS :
NA
Molecular Formula : C27H37ClINO6Si
Molecular Weight : 662.03


Methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(3-chloro-4-(4-hydroxyphenoxy)-5-iodophenyl)propanoate
Methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(3-chloro-4-(4-hydroxyphenoxy)-5-iodophenyl)propanoate
Catalogue No.:PAI 12 008268
CAS :
NA
Molecular Formula : C21H23ClINO6
Molecular Weight : 547.77


(S)-2-((tert-Butoxycarbonyl)amino)-3-(3-chloro-4-(4-hydroxyphenoxy)-5-iodophenyl)propanoic Acid
(S)-2-((tert-Butoxycarbonyl)amino)-3-(3-chloro-4-(4-hydroxyphenoxy)-5-iodophenyl)propanoic Acid
Catalogue No.:PAI 12 008269
CAS :
NA
Molecular Formula : C20H21ClINO6
Molecular Weight : 533.74


((2R,3S,4R,5R,6S)-4,5,6-Trihydroxy-3-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)methyl 4-methylbenzenesulfonate
((2R,3S,4R,5R,6S)-4,5,6-Trihydroxy-3-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)methyl 4-methylbenzenesulfonate
Catalogue No.:PAI 12 008275
CAS :
NA
Molecular Formula : C19H28O13S
Molecular Weight : 496.48


Methyl (2S)-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)-2-(((3,4,5-trihydroxy-6-((3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)methyl)amino)propanoate
Methyl (2S)-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)-2-(((3,4,5-trihydroxy-6-((3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)methyl)amino)propanoate
Catalogue No.:PAI 12 008276
CAS :
NA
Molecular Formula : C28H33I4NO14
Molecular Weight : 1115.18


(2S)-2-(3-(Carboxymethyl)-3-hydroxy-2,5-dioxopyrrolidin-1-yl)-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoic Acid
(2S)-2-(3-(Carboxymethyl)-3-hydroxy-2,5-dioxopyrrolidin-1-yl)-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoic Acid
Catalogue No.:PA 12 0151004
CAS :
NA
Molecular Formula : C21H15I4NO9
Molecular Weight : 932.97


(S)-2-((tert-Butoxycarbonyl)amino)-3-(3-chloro-4-(4-hydroxy-3,5-diiodophenoxy)-5-iodophenyl)propanoic Acid
(S)-2-((tert-Butoxycarbonyl)amino)-3-(3-chloro-4-(4-hydroxy-3,5-diiodophenoxy)-5-iodophenyl)propanoic Acid
Catalogue No.:PAI 12 008271
CAS :
NA
Molecular Formula : C20H19ClI3NO6
Molecular Weight : 785.54


Methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(3-chloro-4-(4-hydroxy-3,5-diiodophenoxy)-5-iodophenyl)propanoate
Methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(3-chloro-4-(4-hydroxy-3,5-diiodophenoxy)-5-iodophenyl)propanoate
Catalogue No.:PAI 12 008270
CAS :
NA
Molecular Formula : C21H21ClI3NO6
Molecular Weight : 799.56


(S)-2-Amino-3-(4-(3-(4-(4-((S)-2-amino-2-carboxyethyl)-2,6-diiodophenoxy)-2,6-diiodophenoxy)-4-hydroxy-5-iodophenoxy)-3,5-diiodophenyl)propanoic Acid
(S)-2-Amino-3-(4-(3-(4-(4-((S)-2-amino-2-carboxyethyl)-2,6-diiodophenoxy)-2,6-diiodophenoxy)-4-hydroxy-5-iodophenoxy)-3,5-diiodophenyl)propanoic Acid
Catalogue No.:PA 12 0151010
CAS :
2088032-62-4
Molecular Formula : C30H21I7N2O8
Molecular Weight : 1425.84


(S,E)-2-((3,5-Di-tert-butyl-4-hydroxybenzylidene)amino)-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoic Acid
(S,E)-2-((3,5-Di-tert-butyl-4-hydroxybenzylidene)amino)-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoic Acid
Catalogue No.:PA 12 0151013
CAS :
NA
Molecular Formula : C30H31I4NO5
Molecular Weight : 993.2