Linagliptin is a medication used to treat diabetes mellitus type 2. It is sold under the brand name Tradjenta. It is used together with exercise and diet. Reference standards of Linagliptin API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
7-(But-2-yn-1-yl)-8-((2-hydroxyethyl)amino)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione
Catalogue No.:PA 12 0471056
CAS :
Molecular Formula : C22H23N7O3
Molecular Weight : 433.47
8-((R)-3-Aminopiperidin-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-7-(penta-2,3-dien-1-yl)-3,7-dihydro-1H-purine-2,6-dione
Catalogue No.:PA 12 0471057
Molecular Formula : C26H30N8O2
Molecular Weight : 486.58
Methyl (R)-2-((1-(7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)carbamoyl)benzoate
Catalogue No.:PA 12 0471058
Molecular Formula : C34H34N8O5
Molecular Weight : 634.7
N-((R)-1-(7-(But-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)-4-methyl-2-((S)-3-(5-methyl-1,3-dioxoisoindolin-2-yl)piperidine-1-carbonyl)benzamide
Catalogue No.:PA 12 0471059
Molecular Formula : C48H48N10O6
Molecular Weight : 860.98
rel-2-((R)-3-Aminopiperidine-1-carbonyl)-N-((R)-1-(7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)benzamide
Catalogue No.:PA 12 0471060
Molecular Formula : C38H42N10O4
Molecular Weight : 702.82
N1,N2-bis((R)-1-(7-(But-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)phthalamide
Catalogue No.:PA 12 0471061
Molecular Formula : C58H58N16O6
Molecular Weight : 1075.21
(R)-2-((1-(7-(But-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)carbamoyl)benzoic Acid
Catalogue No.:PA 12 0471062
Molecular Formula : C33H32N8O5
Molecular Weight : 620.67
(R)-N1-(1-(7-(But-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)-N2-(2-hydroxyethyl)phthalamide
Catalogue No.:PA 12 0471063
Molecular Formula : C35H37N9O5
Molecular Weight : 663.74
tert-Butyl (R)-(1-(3-methyl-1,7-bis((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)carbamate
Catalogue No.:PA 12 0471064
Molecular Formula : C36H40N10O4
Molecular Weight : 676.78
7-(But-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-8-(piperidin-3-ylamino)-3,7-dihydro-1H-purine-2,6-dione
Catalogue No.:PA 12 0471065
Molecular Formula : C25H28N8O2
Molecular Weight : 472.55
tert-Butyl (R)-(1-((4-methylquinazolin-2-yl)methyl)piperidin-3-yl)carbamate
Catalogue No.:PA 12 0471066
Molecular Formula : C20H28N4O2
Molecular Weight : 356.47
Tert-butyl (R)-(1-(7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)(nitroso)carbamate
Catalogue No.:PA 12 0471067
Molecular Formula : C30H35N9O5
Molecular Weight : 601.67
8-(3-Aminopiperidin-1-yl)-7-(but-2-yn-1-yl)-1-((4-(2-((1-(7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)amino)ethyl)quinazolin-2-yl)methyl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione
Catalogue No.:PA 12 0471068
Molecular Formula : C51H56N16O4
Molecular Weight : 957.12
(R)-7-(but-2-yn-1-yl)-3-methyl-8-(3-(methylamino)piperidin-1-yl)-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione
Catalogue No.:PA 12 0471069
7-(but-2-yn-1-yl)-3-Methyl-1-((4-methylquinazolin-2-yl)methyl)-8-((3R)-3-((3,4,5,6-tetrahydroxy-2-oxohexyl)amino)piperidin-1-yl)-3,7-dihydro-1H-purine-2,6-dione
Catalogue No.:PA 12 0471070
Molecular Formula : C31H38N8O7
Molecular Weight : 634.69
(R)-3-((7-(But-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)amino)piperidin-1-yl Pivalate
Catalogue No.:PAI 12 047001
Molecular Formula : C30H36N8O4
Molecular Weight : 572.67
(R)-8-(3-Aminopiperidin-1-yl)-7-butyl-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione
Catalogue No.:PA 12 0471071
Molecular Formula : C25H32N8O2
Molecular Weight : 476.59
(R)-8-(3-Aminopiperidin-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-7-(3- oxobutyl)-1H-purine-2,6(3H,7H)-dione
Catalogue No.:PA 12 0471072
Molecular Formula : C25H30N8O3
Molecular Weight : 490.57
(R)-7-(But-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-8-((1-nitrosopiperidin-3-yl)amino)-3,7-dihydro-1H-purine-2,6-dione
Catalogue No.:PA 12 0471073
Molecular Formula : C25H27N9O3
Molecular Weight : 501.55
8-(3-Aminopiperidin-1-yl)-7-(3-chlorobut-2-en-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione
Catalogue No.:PA 12 0471074
Molecular Formula : C25H29ClN8O2
Molecular Weight : 509.01
tert-Butyl (S)-(1-(7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)carbamate
Catalogue No.:PAI 12 047002
8-Bromo-7-(but-2-yn-1-yl)-3-methyl-1-(quinazolin-2-ylmethyl)-3,7-dihydro-1H-purine-2,6-dione
Catalogue No.:PA 12 0471075
Molecular Formula : C19H15BrN6O2
Molecular Weight : 439.27
7-(But-2-yn-1-yl)-3-methyl-8-(3-(1-methyl-2-(piperidin-3-yl)hydrazinyl)piperidin-1-yl)-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione Hydrochloride
Catalogue No.:PA 12 0471076
Molecular Formula : C31H41ClN10O2
Molecular Weight : 621.19
(R)-8-(3-Aminopiperidin-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-3,9-dihydro-1H-purine-2,6-dione
Catalogue No.:PA 12 0471077
Molecular Formula : C21H24N8O2
Molecular Weight : 420.48
(R)-8-(3-Aminopiperidin-1-yl)-1,7-di(but-2-yn-1-yl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione
Catalogue No.:PA 12 0471078
Molecular Formula : C19H24N6O2
Molecular Weight : 368.44
Diethyl (tert-butoxycarbonyl)-D-glutamate
Catalogue No.:PA 12 0471079
Molecular Formula : C14H25NO6
Molecular Weight : 303.36
7-(But-2-yn-1-yl)-3-methyl-8-((4-methylquinazolin-2-yl)methoxy)-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione
Catalogue No.:PA 12 0471080
Molecular Formula : C30H26N8O3
Molecular Weight : 546.59
Linagliptin Piperidine Impurity
Catalogue No.:PA 12 0471081
Molecular Formula : C31H40N10O2
Molecular Weight : 584.73
7-(But-2-yn-1-yl)-8-((3R)-3-(((3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)amino)piperidin-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione
Catalogue No.:PA 12 0471082
Molecular Formula : C37H48N8O12
Molecular Weight : 796.84
8-((R)-3-Aminopiperidin-1-yl)-7-(but-2-yn-1-yl)-1-((4-((S)-2-(((R)-1-(7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)amino)propyl)quinazolin-2-yl)methyl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione
Catalogue No.:PA 12 0471083
Molecular Formula : C52H58N16O4
Molecular Weight : 971.14
8-Bromo-3-methyl-7-nitroso-3,7-dihydro-1H-purine-2,6-dione
Catalogue No.:PA 12 0471084
Molecular Formula : C6H4BrN5O3
Molecular Weight : 274.03
N-((R)-1-(7-(But-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)-N-((((R)-1-(7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)amino)methyl)nitrous amide
Catalogue No.:PA 12 0471085
Molecular Formula : C51H55N17O5
Molecular Weight : 986.12
N,N'-Methylenebis(N-((R)-1-(7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)nitrous amide)
Catalogue No.:PA 12 0471086
Molecular Formula : C51H54N18O6
Molecular Weight : 1015.11
7-(But-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-8-(3-(((piperidin-3-ylamino)methyl)amino)piperidin-1-yl)-3,7-dihydro-1H-purine-2,6-dione Trihydrochloride
Catalogue No.:PA 12 0471087
Molecular Formula : C31H43Cl3N10O2
Molecular Weight : 694.1
(R)-8-(3-Aminopiperidin-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-7-vinyl-3,7-dihydro-1H-purine-2,6-dione
Catalogue No.:PA 12 0471088
Molecular Formula : C23H26N8O2
Molecular Weight : 446.52
(S)-N-(2-Acetylphenyl)-2-(8-(3-aminopiperidin-1-yl)-7-(but-2-yn-1-yl)-3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-1-yl)acetamide
Catalogue No.:PA 12 0471089
Molecular Formula : C25H29N7O4
Molecular Weight : 491.55
(R)-3-(Boc-Amino)piperidine Hydrochloride
Catalogue No.:PA 12 0471090
Molecular Formula : C10H21ClN2O2
Molecular Weight : 236.74
N-Carbamoyl Linagliptin (Racemic)
Catalogue No.:PA 12 0471091
Molecular Formula : C26H29N9O3
Molecular Weight : 515.58
7-(But-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-8-(3-(((piperidin-3-ylamino)methyl)amino)piperidin-1-yl)-3,7-dihydro-1H-purine-2,6-dione
Catalogue No.:PA 12 0471092
Linagliptin Impurity 1
Catalogue No.:PA 12 0471094
2-((R)-3-Aminopiperidine-1-carbonyl)-N-((R)-1-(7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)benzamide
Catalogue No.:PA 12 0471093
(Z)-8-Bromo-7-(3-bromobut-2-en-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione
Catalogue No.:PA 12 0471096
Molecular Formula : C20H18Br2N6O2
Molecular Weight : 534.21
(3R)-3-Amino-1-(7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidine 1-oxide
Catalogue No.:PA 12 0471095
Molecular Formula : C25H28N8O3
Molecular Weight : 488.55
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