Lumacaftor used in combination with Ivacaftor as the fixed dose combination product Orkambi for the management of Cystic Fibrosis in patients aged 6 years and older. It is a drug. It is available in a single pill with ivacaftor. Reference standards of Lumacaftor API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
Lumacaftor
Catalogue No.:PA 12 95000
CAS :
Molecular Formula : C24H18F2N2O5
Molecular Weight : 452.51
Tert-butyl 3-(1-(3-bromophenyl)-1-hydroxypentyl)benzoate
Catalogue No.:PA 12 95510
Molecular Formula : C22H27BrO3
Molecular Weight : 419.36
Lumacaftor D4
Catalogue No.:PA STI 089143
Molecular Formula : C24H14D4F2N2O5
Molecular Weight : 456.44
1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(5-methyl-6-(3-pentanoylphenyl)pyridin-2-yl)cyclopropane-1-carboxamide
Catalogue No.:PA 12 0951000
Molecular Formula : C28H26F2N2O4
Molecular Weight : 492.52
3-(6-(3-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-5-hydroxy-2-oxopyrrolidin-1-yl)-3-methylpyridin-2-yl)benzoic Acid
Catalogue No.:PA 12 0951001
Molecular Formula : C24H18F2N2O6
Molecular Weight : 468.41
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