Lumateperone and its Impurities
Schizophrenia is a complex mental illness and impacts approximately 1% of the population. It is generally accompanied by significant metabolic and/or neurological adverse effects.Reference standards of Lumateperone API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


(6bR,10aS)-3-Methyl-2,3,6b,7,8,9,10,10a-octahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline
(6bR,10aS)-3-Methyl-2,3,6b,7,8,9,10,10a-octahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline
Catalogue No.:PA 12 1401000
CAS :
313368-85-3
Molecular Formula : C14H19N3
Molecular Weight : 229.33


1-(4-Fluorophenyl)-4-((6bR,10aS)-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)butan-1-one
1-(4-Fluorophenyl)-4-((6bR,10aS)-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)butan-1-one
Catalogue No.:PA 12 1401002
CAS :
313368-82-0
Molecular Formula : C23H26FN3O
Molecular Weight : 379.48


1-(4-Fluorophenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)butan-1-ol
1-(4-Fluorophenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)butan-1-ol
Catalogue No.:PA 12 1401003
CAS :
1469343-42-7
Molecular Formula : C24H30FN3O
Molecular Weight : 395.52


1-(2-Fluorophenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)butan-1-one
1-(2-Fluorophenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)butan-1-one
Catalogue No.:PA 12 1401004
CAS :
NA
Molecular Formula : C24H28FN3O
Molecular Weight : 393.51


4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)-1-(4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)phenyl)butan-1-one
4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)-1-(4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)phenyl)butan-1-one
Catalogue No.:PA 12 1401005
CAS :
2649799-31-3
Molecular Formula : C38H46N6O
Molecular Weight : 602.83


Ethyl (6bR,10aS)-2-oxo-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(7H)-carboxylate
Ethyl (6bR,10aS)-2-oxo-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(7H)-carboxylate
Catalogue No.:PA 12 1401006
CAS :
313369-16-3
Molecular Formula : C16H19N3O3
Molecular Weight : 301.35


Ethyl (6bR,10aS)-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(7H)-carboxylate
Ethyl (6bR,10aS)-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(7H)-carboxylate
Catalogue No.:PA 12 1401007
CAS :
313369-17-4
Molecular Formula : C16H21N3O2
Molecular Weight : 287.36


4-((6bR,10aS)-3-Methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)-1-phenylbutan-1-one
4-((6bR,10aS)-3-Methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)-1-phenylbutan-1-one
Catalogue No.:PA 12 1401011
CAS :
1576239-82-1
Molecular Formula : C24H29N3O
Molecular Weight : 375.52


1-(4-Fluorophenyl)-4-((6bS,10aR)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)butan-1-one
1-(4-Fluorophenyl)-4-((6bS,10aR)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)butan-1-one
Catalogue No.:PA 12 1401012
CAS :
313368-92-2
Molecular Formula : C24H28FN3O
Molecular Weight : 393.51


4,4'-((6bR,10aS)-1,2,6b,9,10,10a-Hexahydro-3H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-3,8(7H)-diyl)bis(1-(4-fluorophenyl)butan-1-one)
4,4'-((6bR,10aS)-1,2,6b,9,10,10a-Hexahydro-3H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-3,8(7H)-diyl)bis(1-(4-fluorophenyl)butan-1-one)
Catalogue No.:PA 12 1401013
CAS :
NA
Molecular Formula : C33H35F2N3O2
Molecular Weight : 543.66


4,4'-((6bR,6b'R,10aS,10a'S)-Methylenebis(3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-5,8(7H)-diyl))bis(1-(4-fluorophenyl)butan-1-one)
4,4'-((6bR,6b'R,10aS,10a'S)-Methylenebis(3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-5,8(7H)-diyl))bis(1-(4-fluorophenyl)butan-1-one)
Catalogue No.:PA 12 1401014
CAS :
NA
Molecular Formula : C49H56F2N6O2
Molecular Weight : 799.02


4,4'-((6bR,10'aS)-3,3'-Dimethyl-2,2',3,3',6b,6'b,9,9',10,10a,10',10'a-dodecahydro-1H,1'H-[5,5'-bipyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline]-8,8'(7H,7'H)-diyl)bis(1-(4-fluorophenyl)butan-1-one)
4,4'-((6bR,10'aS)-3,3'-Dimethyl-2,2',3,3',6b,6'b,9,9',10,10a,10',10'a-dodecahydro-1H,1'H-[5,5'-bipyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline]-8,8'(7H,7'H)-diyl)bis(1-(4-fluorophenyl)butan-1-one)
Catalogue No.:PA 12 1401015
CAS :
NA
Molecular Formula : C48H54F2N6O2
Molecular Weight : 785


Ethyl (6bS,10aR)-3-methyl-2-oxo-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(7H)-carboxylate
Ethyl (6bS,10aR)-3-methyl-2-oxo-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(7H)-carboxylate
Catalogue No.:PA 12 1401019
CAS :
NA
Molecular Formula : C17H21N3O3
Molecular Weight : 315.37


rel-Ethyl (6bR,10aR)-3-methyl-2-oxo-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(7H)-carboxylate
rel-Ethyl (6bR,10aR)-3-methyl-2-oxo-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(7H)-carboxylate
Catalogue No.:PA 12 1401020
CAS :
2702323-64-4
Molecular Formula : C17H21N3O3
Molecular Weight : 315.37


(6bR,10aS)-8-(4-(4-Fluorophenyl)-4-oxobutyl)-3-methyl-6b,7,8,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-2(3H)-one
(6bR,10aS)-8-(4-(4-Fluorophenyl)-4-oxobutyl)-3-methyl-6b,7,8,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-2(3H)-one
Catalogue No.:PA 12 1401023
CAS :
2117618-95-6
Molecular Formula : C24H26FN3O2
Molecular Weight : 407.49


Ethyl (4aR,9bR)-6-bromo-5-(2-(methylamino)-2-oxoethyl)-1,3,4,4a,5,9b-hexahydro-2H-pyrido[4,3-b]indole-2-carboxylate
Ethyl (4aR,9bR)-6-bromo-5-(2-(methylamino)-2-oxoethyl)-1,3,4,4a,5,9b-hexahydro-2H-pyrido[4,3-b]indole-2-carboxylate
Catalogue No.:PA 12 1401030
CAS :
NA
Molecular Formula : C17H22BrN3O3
Molecular Weight : 396.29


Ethyl (4aS,9bS)-6-bromo-5-(2-(methylamino)-2-oxoethyl)-1,3,4,4a,5,9b-hexahydro-2H-pyrido[4,3-b]indole-2-carboxylate
Ethyl (4aS,9bS)-6-bromo-5-(2-(methylamino)-2-oxoethyl)-1,3,4,4a,5,9b-hexahydro-2H-pyrido[4,3-b]indole-2-carboxylate
Catalogue No.:PA 12 1401031
CAS :
NA
Molecular Formula : C17H22BrN3O3
Molecular Weight : 396.29


Ethyl (6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(7H)-carboxylate
Ethyl (6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(7H)-carboxylate
Catalogue No.:PA 12 1401032
CAS :
313369-26-5
Molecular Formula : C17H23N3O2
Molecular Weight : 301.39


(6bR,10aS)-3-Methyl-8-nitroso-2,3,6b,7,8,9,10,10a-octahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline
(6bR,10aS)-3-Methyl-8-nitroso-2,3,6b,7,8,9,10,10a-octahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline
Catalogue No.:PA 12 1401033
CAS :
NA
Molecular Formula : C14H18N4O
Molecular Weight : 258.33