megestrol and its Impurities
Megestrol is used to treat loss of appetite and weight loss because of disease. It is a progestin of the 17α-hydroxyprogesterone group which was never marketed and is not currently used clinically. Reference standards of Megestrol API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
(8R,9S,10R,13R,14S)-17-acetyl-6-(bromomethyl)-10,13-dimethyl-1,2,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
(8R,9S,10R,13R,14S)-17-acetyl-6-(bromomethyl)-10,13-dimethyl-1,2,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
Catalogue No.:PAI 13 009020
CAS :
NA
Molecular Formula : C22H29BrO2
Molecular Weight : 405.38
(6S,8R,9S,10R,13S,14S,17R)-17-Acetoxy-6,10,13-trimethyl-17-((R)-1-(2,2,2-trichloroacetoxy)ethyl)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl 2,2,2-trichloroacetate
Catalogue No.:PAI 13 009060
CAS :
NA
Molecular Formula : C28H36Cl6O6
Molecular Weight : 681.29
(8R,9S,10R,13S,14S,17R)-17-Acetyl-6-(bromomethyl)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl Acetate
(8R,9S,10R,13S,14S,17R)-17-Acetyl-6-(bromomethyl)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl Acetate
Catalogue No.:PAI 13 009070
CAS :
NA
Molecular Formula : C24H33BrO4
Molecular Weight : 465.43
(8R,9S,10R,13S,14S,17R)-17-Acetyl-6,10,13-trimethyl-1,2,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolan]-17-yl Acetate
(8R,9S,10R,13S,14S,17R)-17-Acetyl-6,10,13-trimethyl-1,2,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolan]-17-yl Acetate
Catalogue No.:PAI 13 009080
CAS :
NA
Molecular Formula : C26H38O5
Molecular Weight : 430.59
