melphalan and its Impurities
Melphalan is used to treat multiple myeloma. It is sold under the trade name Alkeran. It is also used to treat a certain type of ovarian cancer. Reference standards of Melphalan API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


(S)-2-Amino-3-(4-((2-chloroethyl)(2-hydroxyethyl)amino)phenyl)propanoic acid hydrochloride
(S)-2-Amino-3-(4-((2-chloroethyl)(2-hydroxyethyl)amino)phenyl)propanoic acid hydrochloride
Catalogue No.:PA 40 0031000
CAS :
1818258-86-4
Molecular Formula : C13H20Cl2N2O3
Molecular Weight : 323.21


Methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-((2-chloroethyl)(2-hydroxyethyl)amino)phenyl)propanoate
Methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-((2-chloroethyl)(2-hydroxyethyl)amino)phenyl)propanoate
Catalogue No.:PAI 13 007129
CAS :
NA
Molecular Formula : C19H29ClN2O5
Molecular Weight : 400.9


Ethyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-((2-(2-chloroethoxy)ethyl)(2-chloroethyl)amino)phenyl)propanoate
Ethyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-((2-(2-chloroethoxy)ethyl)(2-chloroethyl)amino)phenyl)propanoate
Catalogue No.:PAI 13 007131
CAS :
NA
Molecular Formula : C22H34Cl2N2O5
Molecular Weight : 477.42


tert-Butyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-((2-chloroethyl)(2-hydroxyethyl)amino)phenyl)propanoate
tert-Butyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-((2-chloroethyl)(2-hydroxyethyl)amino)phenyl)propanoate
Catalogue No.:PAI 13 007138
CAS :
NA
Molecular Formula : C22H35ClN2O5
Molecular Weight : 442.98


Ethyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-((2-(2-chloroethoxy)ethyl)(2-hydroxyethyl)amino)phenyl)propanoate
Ethyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-((2-(2-chloroethoxy)ethyl)(2-hydroxyethyl)amino)phenyl)propanoate
Catalogue No.:PAI 13 007139
CAS :
NA
Molecular Formula : C22H35ClN2O6
Molecular Weight : 458.98


Methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-((2-(2-chloroethoxy)ethyl)(2-hydroxyethyl)amino)phenyl)propanoate
Methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-((2-(2-chloroethoxy)ethyl)(2-hydroxyethyl)amino)phenyl)propanoate
Catalogue No.:PAI 13 007142
CAS :
NA
Molecular Formula : C21H33ClN2O6
Molecular Weight : 444.95


Methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-((2-(2-chloroethoxy)ethyl)(2-chloroethyl)amino)phenyl)propanoate
Methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-((2-(2-chloroethoxy)ethyl)(2-chloroethyl)amino)phenyl)propanoate
Catalogue No.:PAI 13 007143
CAS :
NA
Molecular Formula : C21H32Cl2N2O5
Molecular Weight : 463.4


Methyl (S)-3-(4-(bis(2-chloroethyl)amino)phenyl)-2-((tert-butoxycarbonyl)amino)propanoate
Methyl (S)-3-(4-(bis(2-chloroethyl)amino)phenyl)-2-((tert-butoxycarbonyl)amino)propanoate
Catalogue No.:PAI 13 007145
CAS :
2514734-95-1
Molecular Formula : C19H28Cl2N2O4
Molecular Weight : 419.34