Midazolam and its Impurities
A benzodiazepine class of medication, Midazolamworks through the GABA neurotransmitter. It is used for the purpoes of anesthesia, procedural sedation, sleeping trouble, and severe agitation. Overdose causes toxicity. Reference standards of Midazolam API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


8-Chloro-6-(2-fluorophenyl)-3a-hydroxy-1-methyl-3a,4-dihydro-3H-benzo[f]imidazo[1,5-a][1,4]diazepin-3-one
8-Chloro-6-(2-fluorophenyl)-3a-hydroxy-1-methyl-3a,4-dihydro-3H-benzo[f]imidazo[1,5-a][1,4]diazepin-3-one
Catalogue No.:PA 13 0451000
CAS :
NA
Molecular Formula : C18H13ClFN3O2
Molecular Weight : 357.77


(2-(5-(Aminomethyl)-2-methyl-1H-imidazol-1-yl)-5-chlorophenyl)(2-fluorophenyl)methanone Dihydrochloride
(2-(5-(Aminomethyl)-2-methyl-1H-imidazol-1-yl)-5-chlorophenyl)(2-fluorophenyl)methanone Dihydrochloride
Catalogue No.:PA 13 0451005
CAS :
59468-73-4
Molecular Formula : C18H17Cl3FN3O
Molecular Weight : 416.7


N-((7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-yl)methyl)acetamide
N-((7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-yl)methyl)acetamide
Catalogue No.:PA 13 0451010
CAS :
59467-68-4
Molecular Formula : C18H17ClFN3O
Molecular Weight : 345.8


(E)-7-Chloro-5-(2-fluorophenyl)-2-(nitromethylene)-2,3-dihydro-1H-benzo[e][1,4]diazepine 4-oxide
(E)-7-Chloro-5-(2-fluorophenyl)-2-(nitromethylene)-2,3-dihydro-1H-benzo[e][1,4]diazepine 4-oxide
Catalogue No.:PA 13 0451012
CAS :
1099229-51-2
Molecular Formula : C16H11ClFN3O3
Molecular Weight : 347.73


Ethyl 2-acetamido-2-(7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-ylidene)acetate
Ethyl 2-acetamido-2-(7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-ylidene)acetate
Catalogue No.:PA 13 0451013
CAS :
59469-47-5
Molecular Formula : C21H19ClFN3O3
Molecular Weight : 415.85


Ethyl 8-chloro-6-(2-fluorophenyl)-1-phenyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate
Ethyl 8-chloro-6-(2-fluorophenyl)-1-phenyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate
Catalogue No.:PA 13 0451014
CAS :
59470-13-2
Molecular Formula : C26H19ClFN3O2
Molecular Weight : 459.91


8-Chloro-6-(2-fluorophenyl)-1-methyl-5-nitroso-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine
8-Chloro-6-(2-fluorophenyl)-1-methyl-5-nitroso-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine
Catalogue No.:PA 13 0451018
CAS :
59469-02-2
Molecular Formula : C18H14ClFN4O
Molecular Weight : 356.79


8-Chloro-6-(2-fluorophenyl)-1-methyl-5-nitroso-3a,4,5,6-tetrahydro-3H-benzo[f]imidazo[1,5-a][1,4]diazepine
8-Chloro-6-(2-fluorophenyl)-1-methyl-5-nitroso-3a,4,5,6-tetrahydro-3H-benzo[f]imidazo[1,5-a][1,4]diazepine
Catalogue No.:PA 13 0451019
CAS :
NA
Molecular Formula : C18H16ClFN4O
Molecular Weight : 358.8


N-((7-Chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-yl)methyl)acetamide-13C2
N-((7-Chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-yl)methyl)acetamide-13C2
Catalogue No.:PA STI 019910
CAS :
2724512-83-6
Molecular Formula : C1613C2H17ClFN3O
Molecular Weight : 347.78


N-((1-Acetyl-7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-yl)methyl)acetamide
N-((1-Acetyl-7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-yl)methyl)acetamide
Catalogue No.:PAI 13 008040
CAS :
NA
Molecular Formula : C20H19ClFN3O2
Molecular Weight : 387.84


Ethyl 8-chloro-6-(2-fluorophenyl)-1-methyl-3a,4-dihydro-3H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate
Ethyl 8-chloro-6-(2-fluorophenyl)-1-methyl-3a,4-dihydro-3H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate
Catalogue No.:PAI 13 008103
CAS :
NA
Molecular Formula : C21H19ClFN3O2
Molecular Weight : 399.85


Ethyl 8-chloro-6-(2-fluorophenyl)-3a,4-dihydro-3H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate
Ethyl 8-chloro-6-(2-fluorophenyl)-3a,4-dihydro-3H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate
Catalogue No.:PAI 13 008104
CAS :
NA
Molecular Formula : C20H17ClFN3O2
Molecular Weight : 385.82


Ethyl 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate
Ethyl 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate
Catalogue No.:PAI 13 008105
CAS :
59469-49-7
Molecular Formula : C21H17ClFN3O2
Molecular Weight : 397.83


Dimethyl 2-(7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-ylidene)malonate
Dimethyl 2-(7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-ylidene)malonate
Catalogue No.:PAI 13 008110
CAS :
59468-39-2
Molecular Formula : C20H16ClFN2O4
Molecular Weight : 402.81


Methyl (E)-2-(7-chloro-5-(2-fluorophenyl)-3H-benzo[e][1,4]diazepin-2-yl)-2-(hydroxyimino)acetate
Methyl (E)-2-(7-chloro-5-(2-fluorophenyl)-3H-benzo[e][1,4]diazepin-2-yl)-2-(hydroxyimino)acetate
Catalogue No.:PAI 13 008111
CAS :
NA
Molecular Formula : C18H13ClFN3O3
Molecular Weight : 373.77


Diethyl 2-(7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-ylidene)malonate
Diethyl 2-(7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-ylidene)malonate
Catalogue No.:PAI 13 008115
CAS :
80530-58-1
Molecular Formula : C22H20ClFN2O4
Molecular Weight : 430.86