Molnupiravir and its Impurities
Molnupiravir is an experimental antiviral drug which is orally active and was developed for the treatment of influenza. EIDD-2801 is an orally bioavailable isopropylester cytidine analog being investigated to treat COVID-19. Reference standards of Molnupiravir API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-one
1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-one
Catalogue No.:PA 13 2381001
CAS :
13491-41-3
Molecular Formula : C9H13N3O6
Molecular Weight : 259.22


1-((2S,3S,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-one
1-((2S,3S,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-one
Catalogue No.:PA 13 2381002
CAS :
402725-23-9
Molecular Formula : C9H13N3O6
Molecular Weight : 259.22


((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl isobutyrate
((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl isobutyrate
Catalogue No.:PA 13 2381003
CAS :
886538-46-1
Molecular Formula : C13H19N3O6
Molecular Weight : 313.31


((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl isobutyrate
((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl isobutyrate
Catalogue No.:PA 13 2381004
CAS :
886538-48-3
Molecular Formula : C13H18N2O7
Molecular Weight : 314.29


((2R,3S,4R,5R)-3,4-Dihydroxy-5-((E)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate
((2R,3S,4R,5R)-3,4-Dihydroxy-5-((E)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate
Catalogue No.:PA 13 2381007
CAS :
2492423-30-8
Molecular Formula : C13H19N3O7
Molecular Weight : 329.31


((3aR,4R,6R,6aR)-6-(4-Amino-2-oxopyrimidin-1(2H)-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl isobutyrate
((3aR,4R,6R,6aR)-6-(4-Amino-2-oxopyrimidin-1(2H)-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl isobutyrate
Catalogue No.:PA 13 2381006
CAS :
1686124-74-2
Molecular Formula : C16H23N3O6
Molecular Weight : 353.38


((2R,3S,4R,5R)-3,4-Dihydroxy-5-(4-(hydroxyamino)-2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl Acetate
((2R,3S,4R,5R)-3,4-Dihydroxy-5-(4-(hydroxyamino)-2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl Acetate
Catalogue No.:PA 13 2381010
CAS :
NA
Molecular Formula : C11H15N3O7
Molecular Weight : 301.26


((3aR,4R,6R,6aR)-6-(4,6-Bis(hydroxyamino)-2-oxo-5,6-dihydropyrimidin-1(2H)-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl Isobutyrate
((3aR,4R,6R,6aR)-6-(4,6-Bis(hydroxyamino)-2-oxo-5,6-dihydropyrimidin-1(2H)-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl Isobutyrate
Catalogue No.:PA 13 2381013
CAS :
NA
Molecular Formula : C16H26N4O8
Molecular Weight : 402.4


(2R,3R,4R,5R)-2-(4-(Hydroxyamino)-2-oxopyrimidin-1(2H)-yl)-5-((isobutyryloxy)methyl)tetrahydrofuran-3,4-diyl bis(2-methylpropanoate)
(2R,3R,4R,5R)-2-(4-(Hydroxyamino)-2-oxopyrimidin-1(2H)-yl)-5-((isobutyryloxy)methyl)tetrahydrofuran-3,4-diyl bis(2-methylpropanoate)
Catalogue No.:PA 13 2381014
CAS :
2346619-88-1
Molecular Formula : C21H31N3O9
Molecular Weight : 469.49


((2S,3R,4S,5S)-3,4-Dihydroxy-5-(4-(hydroxyamino)-2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate
((2S,3R,4S,5S)-3,4-Dihydroxy-5-(4-(hydroxyamino)-2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate
Catalogue No.:PA 13 2381016
CAS :
NA
Molecular Formula : C13H19N3O7
Molecular Weight : 329.31


((2R,3S,4R,5S)-3,4-Dihydroxy-5-((Z)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate
((2R,3S,4R,5S)-3,4-Dihydroxy-5-((Z)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate
Catalogue No.:PA 13 2381017
CAS :
2920217-33-8
Molecular Formula : C13H19N3O7
Molecular Weight : 329.31


((3aR,4R,6R,6aR)-6-(2,4-bis(Hydroxyamino)pyrimidin-1(2H)-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl Isobutyrate
((3aR,4R,6R,6aR)-6-(2,4-bis(Hydroxyamino)pyrimidin-1(2H)-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl Isobutyrate
Catalogue No.:PA 13 2381018
CAS :
NA
Molecular Formula : C16H26N4O7
Molecular Weight : 386.41


((3aR,4R,6R,6aR)-6-(2,4-dioxo-3,4-Dihydropyrimidin-1(2H)-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl isobutyrate
((3aR,4R,6R,6aR)-6-(2,4-dioxo-3,4-Dihydropyrimidin-1(2H)-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl isobutyrate
Catalogue No.:PA 13 2381019
CAS :
2346620-53-7
Molecular Formula : C16H22N2O7
Molecular Weight : 354.36