Nalfurafine and its Impurities
Nalfurafine (INN, USAN) (brand name Remitch, former developmental code names TRK-820, AC-820, MT-9938) is an antipruritic (anti-itch drug) that is marketed in Japan for the treatment of uremic pruritus in individuals with chronic kidney disease undergoing hemodialysis. Reference standards of Nalfurafine API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
(4R,4aS,7S,7aR,12bS)-7-(Benzyl(methyl)amino)-3-(cyclopropylmethyl)-1,2,3,4,5,6,7,7a-octahydro-4aH-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol
(4R,4aS,7S,7aR,12bS)-7-(Benzyl(methyl)amino)-3-(cyclopropylmethyl)-1,2,3,4,5,6,7,7a-octahydro-4aH-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol
Catalogue No.:PA 14 1231004
CAS :
NA
Molecular Formula : C28H34N2O3
Molecular Weight : 446.59
(E)-N-((4R,4aS,7R,7aR,12bS,13S)-3-(Cyclopropylmethyl)-4a,9,13-trihydroxy-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl)-3-(furan-2-yl)-N-methylacrylamide
(E)-N-((4R,4aS,7R,7aR,12bS,13S)-3-(Cyclopropylmethyl)-4a,9,13-trihydroxy-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl)-3-(furan-2-yl)-N-methylacrylamide
Catalogue No.:PA 14 1231005
CAS :
2133305-36-7
Molecular Formula : C28H32N2O6
Molecular Weight : 492.57