Narlaprevir and its Impurities
Narlaprevir (trade name Arlansa, codenamed SCH 900518), is an inhibitor of NS3/4A serine protease, intended for the treatment of chronic hepatitis C caused by genotype 1 virus in combination with other antiviral drugs. Reference standards of Narlaprevir API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
Methyl (1R,2S,5S)-3-((S)-2-(3-(1-((tert-butylsulfonyl)methyl)cyclohexyl)ureido)-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate
Methyl (1R,2S,5S)-3-((S)-2-(3-(1-((tert-butylsulfonyl)methyl)cyclohexyl)ureido)-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate
Catalogue No.:PA 14 1441000
CAS :
1208245-88-8
Molecular Formula : C27H47N3O6S
Molecular Weight : 541.75
(1R,2S,5S)-3-((S)-2-(3-(1-((tert-Butylsulfonyl)methyl)cyclohexyl)ureido)-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic Acid
(1R,2S,5S)-3-((S)-2-(3-(1-((tert-Butylsulfonyl)methyl)cyclohexyl)ureido)-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic Acid
Catalogue No.:PA 14 1441001
CAS :
1229337-32-9
Molecular Formula : C26H45N3O6S
Molecular Weight : 527.72
(1R,2S,5S)-3-((S)-2-(3-(1-((tert-Butylsulfonyl)methyl)cyclohexyl)ureido)-3,3-dimethylbutanoyl)-N-((2S,3S)-1-(cyclopropylamino)-2-hydroxy-1-oxoheptan-3-yl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
(1R,2S,5S)-3-((S)-2-(3-(1-((tert-Butylsulfonyl)methyl)cyclohexyl)ureido)-3,3-dimethylbutanoyl)-N-((2S,3S)-1-(cyclopropylamino)-2-hydroxy-1-oxoheptan-3-yl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
Catalogue No.:PA 14 1441002
CAS :
1256345-29-5
Molecular Formula : C36H63N5O7S
Molecular Weight : 709.99
