nebivolol and its Impurities
A cardioselective β1 receptor blocker, Nebivolol is used for the treatment of hyertension. It works by blocking the action of certain natural substances in your body, such as epinephrine, on the heart and blood vessels. This lowers the heart rate and blood pressure. Reference standards of Nebivolol API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
Nebivolol Hydrochloride - Impurity C
(1RS)-2-[benzyl[(2RS)-2-[(2RS)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-2-hydroxyethyl]amino]-1-[(2SR)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]ethan-1-ol and (1RS)-2-[benzyl[(2SR)-2-[(2RS)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-2-hydroxyethyl]amino]-1-[(2RS)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]ethan-1-ol,
Catalogue No.:PA 14 15510
CAS :
929706-85-4
Molecular Formula : C29H31F2NO4
Molecular Weight : 495.56
(S)-1-((S)-6-Fluorochroman-2-yl)-2-(((R)-2-((S)-6-fluorochroman-2-yl)-2-hydroxyethyl)amino)ethanol
(S)-1-((S)-6-Fluorochroman-2-yl)-2-(((R)-2-((S)-6-fluorochroman-2-yl)-2-hydroxyethyl)amino)ethanol
Catalogue No.:PA 14 15690
CAS :
119365-25-2
Molecular Formula : C22H25F2NO4
Molecular Weight : 405.44
6-Fluoro-3,4-dihydro-α-[[(benzyl)amino]methyl]-2H-1-benzopyran-2-methanol-d2 (Mixture of Diastereomers)
6-Fluoro-3,4-dihydro-α-[[(benzyl)amino]methyl]-2H-1-benzopyran-2-methanol-d2 (Mixture of Diastereomers)
Catalogue No.:PA STI 041810
CAS :
1285866-07-0
Molecular Formula : C18H18D2FNO2
Molecular Weight : 303.37
Nebivolol Related Compound C (COLD SHIPMENT REQUIRED) ((RS)-6-Fluoro-2-[(RS)-oxiran-2-yl]chroman) (1457877)
Nebivolol Related Compound C (COLD SHIPMENT REQUIRED) ((RS)-6-Fluoro-2-[(RS)-oxiran-2-yl]chroman) (1457877)
Catalogue No.:PA USP1457877
CAS :
876514-31-7
Molecular Formula : NA
Molecular Weight : NA
(S)-1-((R)-6-Fluorochroman-2-yl)-2-(((R)-2-((R)-6-fluorochroman-2-yl)-2-hydroxyethyl)amino)ethan-1-ol
(S)-1-((R)-6-Fluorochroman-2-yl)-2-(((R)-2-((R)-6-fluorochroman-2-yl)-2-hydroxyethyl)amino)ethan-1-ol
Catalogue No.:PA 14 15790
CAS :
119365-26-3
Molecular Formula : C22H25F2NO4
Molecular Weight : 405.44
(S)-1-((R)-6-Fluorochroman-2-yl)-2-(((R)-2-((S)-6-fluorochroman-2-yl)-2-hydroxyethyl)amino)ethan-1-ol hydrochloride
(S)-1-((R)-6-Fluorochroman-2-yl)-2-(((R)-2-((S)-6-fluorochroman-2-yl)-2-hydroxyethyl)amino)ethan-1-ol hydrochloride
Catalogue No.:PA 14 0551001
CAS :
920275-26-9
Molecular Formula : C22H26ClF2NO4
Molecular Weight : 441.9
(S)-1-((S)-6-Fluorochroman-2-yl)-2-(((R)-2-((S)-6-fluorochroman-2-yl)-2-hydroxyethyl)amino)ethan-1-ol hydrochloride
(S)-1-((S)-6-Fluorochroman-2-yl)-2-(((R)-2-((S)-6-fluorochroman-2-yl)-2-hydroxyethyl)amino)ethan-1-ol hydrochloride
Catalogue No.:PA 14 0151014
CAS :
920299-27-0
Molecular Formula : C22H26ClF2NO4
Molecular Weight : 441.9
(R)-1-((R)-Chroman-2-yl)-2-(((R)-2-((S)-6-fluorochroman-2-yl)-2-hydroxyethyl) amino)ethan-1-ol
(R)-1-((R)-Chroman-2-yl)-2-(((R)-2-((S)-6-fluorochroman-2-yl)-2-hydroxyethyl) amino)ethan-1-ol
Catalogue No.:PA 14 0151013
CAS :
1696472-15-7
Molecular Formula : C22H26FNO4
Molecular Weight : 387.45
(R)-2-(Benzyl((R)-2-((R)-6-fluorochroman-2-yl)-2-hydroxyethyl)amino)-1-((S)-6-fluorochroman-2-yl)ethan-1-ol
(R)-2-(Benzyl((R)-2-((R)-6-fluorochroman-2-yl)-2-hydroxyethyl)amino)-1-((S)-6-fluorochroman-2-yl)ethan-1-ol
Catalogue No.:PA 14 0151012
CAS :
1030385-17-1
Molecular Formula : C29H31F2NO4
Molecular Weight : 495.57
(S)-1-((R)-Chroman-2-yl)-2-(((S)-2-((S)-6-fluorochroman-2-yl)-2-hydroxyethyl)amino)ethan-1-ol;
(S)-1-((R)-Chroman-2-yl)-2-(((S)-2-((S)-6-fluorochroman-2-yl)-2-hydroxyethyl)amino)ethan-1-ol;
Catalogue No.:PA 14 0151011
CAS :
129101-35-5
Molecular Formula : C22H26FNO4
Molecular Weight : 387.45
(R)-1-((S)-Chroman-2-yl)-2-(((R)-2-((R)-6-fluorochroman-2-yl)-2-hydroxyethyl)amino)ethan-1-ol
(R)-1-((S)-Chroman-2-yl)-2-(((R)-2-((R)-6-fluorochroman-2-yl)-2-hydroxyethyl)amino)ethan-1-ol
Catalogue No.:PA 14 0151010
CAS :
1696472-14-6
Molecular Formula : C22H26FNO4
Molecular Weight : 387.45
rel-(S)-1-((R)-6-Fluorochroman-2-yl)-2-(((S)-2-((S)-6-fluorochroman-2-yl)-2-hydroxyethyl-1,1-d2)amino)ethan-2,2-d2-1-ol
rel-(S)-1-((R)-6-Fluorochroman-2-yl)-2-(((S)-2-((S)-6-fluorochroman-2-yl)-2-hydroxyethyl-1,1-d2)amino)ethan-2,2-d2-1-ol
Catalogue No.:PA STI 089444
CAS :
2124271-47-0
Molecular Formula : C22H21D4F2NO4
Molecular Weight : 409.47
(R)-2-((S)-6-Fluorochroman-2-yl)-2-(tosyloxy)ethyl Acetate compound with (S)-2-((R)-6-Fluorochroman-2-yl)-2-(tosyloxy)ethyl Acetate (1:1)
(R)-2-((S)-6-fluorochroman-2-yl)-2-(tosyloxy)ethyl Acetate compound with (S)-2-((R)-6-fluorochroman-2-yl)-2-(tosyloxy)ethyl Acetate (1:1)
Catalogue No.:PA 14 0151035
CAS :
NA
Molecular Formula : C20H21FO6S
Molecular Weight : 408.44
2-(Benzyl((R)-2-((S)-6-fluorochroman-2-yl)-2-hydroxyethyl)amino)-1-(6-fluorochroman-2-yl)ethan-1-one compound with 2-(benzyl((S)-2-((R)-6-fluorochroman-2-yl)-2-hydroxyethyl)amino)-1-(6-fluorochroman-2-yl)ethan-1-one (1:1)
2-(Benzyl((R)-2-((S)-6-fluorochroman-2-yl)-2-hydroxyethyl)amino)-1-(6-fluorochroman-2-yl)ethan-1-one compound with 2-(benzyl((S)-2-((R)-6-fluorochroman-2-yl)-2-hydroxyethyl)amino)-1-(6-fluorochroman-2-yl)ethan-1-one (1:1)
Catalogue No.:PA 14 0151039
CAS :
NA
Molecular Formula : C29H29F2NO4
Molecular Weight : 493.55
rel-2-(Benzyl((R)-2-((S)-6-fluorochroman-2-yl)-2-hydroxyethyl)amino)-1-((R)-6-fluorochroman-2-yl)ethan-1-one
rel-2-(Benzyl((R)-2-((S)-6-fluorochroman-2-yl)-2-hydroxyethyl)amino)-1-((R)-6-fluorochroman-2-yl)ethan-1-one
Catalogue No.:PA 14 0151040
CAS :
943126-74-7
Molecular Formula : C29H29F2NO4
Molecular Weight : 493.55
