Nelarabine and its Impurities
Nelarabine is an antineoplastic agent that is typically employed to treat acute T-cell lymphoblastic leukemia. Nelarabine is a purine nucleoside analog converted to its corresponding arabinosylguanine nucleotide triphosphate (araGTP), resulting in inhibition of DNA synthesis and cytotoxicity. Reference standards of Nelarabine API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
9-((2R,3S,4R,5R)-3,4-Bis((2,4-dichlorobenzyl)oxy)-5-(((2,4-dichlorobenzyl)oxy)methyl)tetrahydrofuran-2-yl)-6-methoxy-9H-purin-2-amine
9-((2R,3S,4R,5R)-3,4-Bis((2,4-dichlorobenzyl)oxy)-5-(((2,4-dichlorobenzyl)oxy)methyl)tetrahydrofuran-2-yl)-6-methoxy-9H-purin-2-amine
Catalogue No.:PA 14 1241003
CAS :
1173825-84-7
Molecular Formula : C32H27Cl6N5O5
Molecular Weight : 774.3
(2R,3R,4S,5R)-2-(Acetoxymethyl)-5-(6-methoxy-2-oxo-2,3-dihydro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate
(2R,3R,4S,5R)-2-(Acetoxymethyl)-5-(6-methoxy-2-oxo-2,3-dihydro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate
Catalogue No.:PA 14 1241004
CAS :
NA
Molecular Formula : C17H20N4O9
Molecular Weight : 424.37
