Neratinib is used as an adjuvant therapy in people with early stage breast cancer in which HER2 is overexpressed, after the person receives treatment with trastuzumab. It is a tyrosine kinase inhibitor anticancer drug. Reference standards of Neratinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
Neratinib
Catalogue No.:PA 14 74000
CAS :
Molecular Formula : C30H29ClN6O3
Molecular Weight : 557.04
Neratinib-d6
Catalogue No.:PA STI 067320
Molecular Formula : C30H23D6ClN6O3
Molecular Weight : 563.08
4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxy-6-(2-hydroxy-5-oxopyrrolidin-1-yl)quinoline-3-carbonitrile
Catalogue No.:PA 14 74510
Molecular Formula : C28H24ClN5O4
Molecular Weight : 529.98
(E)-4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-6-(4-(dimethylamino)but-2-enamido)-7-ethoxyquinoline-3-carboxylic Acid
Catalogue No.:PA 14 74520
Molecular Formula : C30H30ClN5O5
Molecular Weight : 576.05
N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-methoxyquinolin-6-yl)acetamide
Catalogue No.:PA 14 74530
Molecular Formula : C25H20ClN5O3
Molecular Weight : 473.92
(E)-N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(methylamino)but-2-enamide
Catalogue No.:PA 14 74540
Molecular Formula : C29H27ClN6O3
Molecular Weight : 543.02
(E)-N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-methoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide
Catalogue No.:PA 14 74550
(E)-N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-hydroxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide
Catalogue No.:PA 14 74560
Molecular Formula : C28H25ClN6O3
Molecular Weight : 529
(E)-N-(4-((3-Chloro-4-hydroxyphenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide
Catalogue No.:PA 14 74570
Molecular Formula : C24H24ClN5O3
Molecular Weight : 465.94
(Z)-N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide
Catalogue No.:PA 14 0741000
Molecular Weight : 557.05
N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)formamide
Catalogue No.:PA 14 0741001
6-Amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile
Catalogue No.:PA 14 0741002
Molecular Formula : C24H20ClN5O2
Molecular Weight : 445.91
Neratinib pyridine N-oxide (M3)
Catalogue No.:PA 14 0741003
Molecular Formula : C30H29ClN6O4
Molecular Weight : 573.05
Neratinib dimethylamine N-oxide (M7)
Catalogue No.:PA 14 0741004
N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)acetamide
Catalogue No.:PA 14 0741005
Molecular Formula : C26H22ClN5O3
Molecular Weight : 487.94
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