neratinib and its Impurities
Neratinib is used as an adjuvant therapy in people with early stage breast cancer in which HER2 is overexpressed, after the person receives treatment with trastuzumab. It is a tyrosine kinase inhibitor anticancer drug. Reference standards of Neratinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxy-6-(2-hydroxy-5-oxopyrrolidin-1-yl)quinoline-3-carbonitrile
4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxy-6-(2-hydroxy-5-oxopyrrolidin-1-yl)quinoline-3-carbonitrile
Catalogue No.:PA 14 74510
CAS :
1144516-15-3
Molecular Formula : C28H24ClN5O4
Molecular Weight : 529.98
(E)-4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-6-(4-(dimethylamino)but-2-enamido)-7-ethoxyquinoline-3-carboxylic Acid
(E)-4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-6-(4-(dimethylamino)but-2-enamido)-7-ethoxyquinoline-3-carboxylic Acid
Catalogue No.:PA 14 74520
CAS :
NA
Molecular Formula : C30H30ClN5O5
Molecular Weight : 576.05
N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-methoxyquinolin-6-yl)acetamide
N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-methoxyquinolin-6-yl)acetamide
Catalogue No.:PA 14 74530
CAS :
2748212-19-1
Molecular Formula : C25H20ClN5O3
Molecular Weight : 473.92
(E)-N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(methylamino)but-2-enamide
(E)-N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(methylamino)but-2-enamide
Catalogue No.:PA 14 74540
CAS :
915788-27-1
Molecular Formula : C29H27ClN6O3
Molecular Weight : 543.02
(E)-N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-methoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide
(E)-N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-methoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide
Catalogue No.:PA 14 74550
CAS :
NA
Molecular Formula : C29H27ClN6O3
Molecular Weight : 543.02
(E)-N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-hydroxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide
(E)-N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-hydroxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide
Catalogue No.:PA 14 74560
CAS :
NA
Molecular Formula : C28H25ClN6O3
Molecular Weight : 529
(E)-N-(4-((3-Chloro-4-hydroxyphenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide
(E)-N-(4-((3-Chloro-4-hydroxyphenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide
Catalogue No.:PA 14 74570
CAS :
1895881-83-0
Molecular Formula : C24H24ClN5O3
Molecular Weight : 465.94
(Z)-N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide
(Z)-N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide
Catalogue No.:PA 14 0741000
CAS :
2186660-79-5
Molecular Formula : C30H29ClN6O3
Molecular Weight : 557.05
N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)formamide
N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)formamide
Catalogue No.:PA 14 0741001
CAS :
1144516-20-0
Molecular Formula : C25H20ClN5O3
Molecular Weight : 473.92
6-Amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile
6-Amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile
Catalogue No.:PA 14 0741002
CAS :
848139-78-6
Molecular Formula : C24H20ClN5O2
Molecular Weight : 445.91
N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)acetamide
N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)acetamide
Catalogue No.:PA 14 0741005
CAS :
915941-95-6
Molecular Formula : C26H22ClN5O3
Molecular Weight : 487.94
