Netarsudil and its Impurities
Netarsudil, sold under the brand name Rhopressa, is a medication for the treatment of glaucoma. Reference standards of Netarsudil API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


(R)-4-(3-Amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate Dimethanesulfonate
(R)-4-(3-Amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate Dimethanesulfonate
Catalogue No.:PA 14 1201000
CAS :
NA
Molecular Formula : C30H35N3O9S2
Molecular Weight : 645.74


4-(3-(1,3-Dioxoisoindolin-2-yl)-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-Dimethylbenzoate
4-(3-(1,3-Dioxoisoindolin-2-yl)-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-Dimethylbenzoate
Catalogue No.:PA 14 1201001
CAS :
NA
Molecular Formula : C36H29N3O5
Molecular Weight : 583.64


(S)-4-(3-((Tert-butoxycarbonyl)amino)-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate
(S)-4-(3-((Tert-butoxycarbonyl)amino)-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate
Catalogue No.:PA 14 1201002
CAS :
1253955-19-9
Molecular Formula : C33H35N3O5
Molecular Weight : 553.66


tert-Butyl (S)-(2-(4-(hydroxymethyl)phenyl)-3-(isoquinolin-6-ylamino)-3-oxopropyl)carbamate
tert-Butyl (S)-(2-(4-(hydroxymethyl)phenyl)-3-(isoquinolin-6-ylamino)-3-oxopropyl)carbamate
Catalogue No.:PA 14 1201008
CAS :
2166548-09-8
Molecular Formula : C24H27N3O4
Molecular Weight : 421.5


(S)-3-((tert-Butoxycarbonyl)amino)-2-(4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)propanoic Acid
(S)-3-((tert-Butoxycarbonyl)amino)-2-(4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)propanoic Acid
Catalogue No.:PA 14 1201009
CAS :
2566703-27-1
Molecular Formula : C21H35NO5Si
Molecular Weight : 409.6


3-((tert-Butoxycarbonyl)amino)-2-(4-(((triisopropylsilyl)oxy)methyl)phenyl)propanoic Acid
3-((tert-Butoxycarbonyl)amino)-2-(4-(((triisopropylsilyl)oxy)methyl)phenyl)propanoic Acid
Catalogue No.:PA 14 1201010
CAS :
1253955-24-6
Molecular Formula : C24H41NO5Si
Molecular Weight : 451.68