Neurotinib and its Impurities

Neurotinib (NCATS-SM1976) is a potent, selective c-Abl allosteric inhibitor, reduces c-Abl phosphorylation and the activation of CRKII, shows potential to prevent epileptic-like seizure. Reference standards of Neurotinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.