nicergoline and its Impurities
A derivative of ergot fungi, Nicergoline is used for treating vascular disorders such as cerebral thrombosis and atherosclerosis. It is a selective alpha-1A adrenergic receptor antagonist and works by increasing the blood flow in the brain. Reference standards of Nicergoline API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
((6aR,9R,10aS)-10a-methoxy-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)methanol
((6aR,9R,10aS)-10a-methoxy-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)methanol
Catalogue No.:PAI 14 018001
CAS :
NA
Molecular Formula : C17H22N2O2
Molecular Weight : 286.38
Nicergoline - Impurity I
[(6aR,6a'R,9R,9'R,10aS,10a'S)-9'-[[[(5-Bromopyridin-3-yl)carbonyl]oxy]methyl]-10a,10a'-dimethoxy-7,7'-dimethyl-4',6',6a,6a',7,7',8,8',9,9',10,10',10a,10a'-tetradecahydro-6H-4,5'-biindolo[4,3-fg]quinoline-9-yl]methyl 5-bromopyridine-3-carboxylate
Catalogue No.:PA 14 0180090
CAS :
NA
Molecular Formula : C46H46Br2N6O6
Molecular Weight : 938.72
Nicergoline - Impurity J
[(6aR,6a'R,9R,9'R,10aS,10a'S)-9'-[[[(5-Bromopyridin-3-yl)carbonyl]oxy]methyl]-10a,10a'-dimethoxy-4',7,7'-trimethyl-4',6',6a,6a',7,7',8,8',9,9',10,10',10a,10a'-tetradecahydro-6H-4,5'-biindolo[4,3-fg]quinoline-9-yl]methyl 5-bromopyridine-3-carboxylate
Catalogue No.:PA 14 0180100
CAS :
NA
Molecular Formula : C47H48Br2N6O6
Molecular Weight : 952.75
((6aR,9R,10aS)-10a-methoxy-4-methyl-7-nitroso-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)methyl 5-bromonicotinate
((6aR,9R,10aS)-10a-methoxy-4-methyl-7-nitroso-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl)methyl 5-bromonicotinate
Catalogue No.:PA 14 0181000
CAS :
57682-67-4
Molecular Formula : C23H23BrN4O4
Molecular Weight : 499.37
