nintedanib and its Impurities
A Nintedanib is used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer. It is a small molecule kinase inhibitor. Reference standards of Nintedanib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
Methyl (Z)-1-acetyl-3-((4-chloro-3-nitrophenyl)(hydroxy)methylene)-2-oxoindoline-6-carboxylate
Methyl (Z)-1-acetyl-3-((4-chloro-3-nitrophenyl)(hydroxy)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541075
CAS :
NA
Molecular Formula : C19H13ClN2O7
Molecular Weight : 416.77
Methyl (Z)-3-(((4-(2-(4-ethylpiperazin-1-yl)-N-methylacetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Methyl (Z)-3-(((4-(2-(4-ethylpiperazin-1-yl)-N-methylacetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541067
CAS :
NA
Molecular Formula : C32H35N5O4
Molecular Weight : 553.66
(Z)-2-((4-(((6-(Methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoacetic Acid
(Z)-2-((4-(((6-(Methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoacetic Acid
Catalogue No.:PA 14 0541080
CAS :
NA
Molecular Formula : C26H21N3O6
Molecular Weight : 471.47
Methyl (Z)-3-(2-((4-(2-(4-ethylpiperazin-1-yl)-N-methylacetamido)phenyl)amino)benzylidene)-2-oxoindoline-6-carboxylate
Methyl (Z)-3-(2-((4-(2-(4-ethylpiperazin-1-yl)-N-methylacetamido)phenyl)amino)benzylidene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541082
CAS :
NA
Molecular Formula : C32H35N5O4
Molecular Weight : 553.66
Methyl (E)-3-(((4-(2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Methyl (E)-3-(((4-(2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541083
CAS :
NA
Molecular Formula : C30H31N5O4
Molecular Weight : 525.61
