nintedanib and its Impurities
A Nintedanib is used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer. It is a small molecule kinase inhibitor. Reference standards of Nintedanib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
 
	
			                                   
																				Methyl (Z)-1-acetyl-3-((4-chloro-3-nitrophenyl)(hydroxy)methylene)-2-oxoindoline-6-carboxylate
Methyl (Z)-1-acetyl-3-((4-chloro-3-nitrophenyl)(hydroxy)methylene)-2-oxoindoline-6-carboxylate
- Catalogue No.:PA 14 0541075 
- CAS : - NA
- Molecular Formula : C19H13ClN2O7 
- Molecular Weight : 416.77 
 
	
			                                   
																				Methyl (Z)-3-(((4-(2-(4-ethylpiperazin-1-yl)-N-methylacetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Methyl (Z)-3-(((4-(2-(4-ethylpiperazin-1-yl)-N-methylacetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
- Catalogue No.:PA 14 0541067 
- CAS : - NA
- Molecular Formula : C32H35N5O4 
- Molecular Weight : 553.66 
 
	
			                                   
																				(Z)-2-((4-(((6-(Methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoacetic Acid
(Z)-2-((4-(((6-(Methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoacetic Acid
- Catalogue No.:PA 14 0541080 
- CAS : - NA
- Molecular Formula : C26H21N3O6 
- Molecular Weight : 471.47 

 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
 
 
 
