omacetaxine mepesuccinate and its Impurities
A naturally occurring drug used for the treatment of chronic myeloid leukemia . Also known as homoharringtonine , it is a protein translation inhibitor.Omacetaxine Mepesuccinate is an ester derivative of cephalotaxine.Reference standards of Omacetaxine Mepesuccinate API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
(11bS,12S,14aR)-2,3,5,6,11b,12-Hexahydro-1H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepine-12,13-diol
(11bS,12S,14aR)-2,3,5,6,11b,12-Hexahydro-1H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepine-12,13-diol
Catalogue No.:PA 15 39530
CAS :
NA
Molecular Formula : C17H19NO4
Molecular Weight : 301.34
(R)-3,7-Dihydroxy-3-((((11bS,12S,14aR)-13-hydroxy-2,3,5,6,11b,12-hexahydro-1H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-12-yl)oxy)carbonyl)-7-methyloctanoic Acid
(R)-3,7-Dihydroxy-3-((((11bS,12S,14aR)-13-hydroxy-2,3,5,6,11b,12-hexahydro-1H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-12-yl)oxy)carbonyl)-7-methyloctanoic Acid
Catalogue No.:PA 15 39550
CAS :
NA
Molecular Formula : C27H35NO9
Molecular Weight : 517.57
(R)-3-Hydroxy-3-((((11bS,12S,14aR)-13-hydroxy-2,3,5,6,11b,12-hexahydro-1H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-12-yl)oxy)carbonyl)-7-methyloct-7-enoic Acid
(R)-3-Hydroxy-3-((((11bS,12S,14aR)-13-hydroxy-2,3,5,6,11b,12-hexahydro-1H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-12-yl)oxy)carbonyl)-7-methyloct-7-enoic Acid
Catalogue No.:PA 15 39560
CAS :
NA
Molecular Formula : C27H33NO8
Molecular Weight : 499.55
(R)-1-((11bS,12S,14aR)-13-Methoxy-2,3,5,6,11b,12-hexahydro-1H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-12-yl) 4-methyl 2-hydroxy-2-(4-methylpent-4-en-1-yl)succinate
(R)-1-((11bS,12S,14aR)-13-Methoxy-2,3,5,6,11b,12-hexahydro-1H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-12-yl) 4-methyl 2-hydroxy-2-(4-methylpent-4-en-1-yl)succinate
Catalogue No.:PA 15 39570
CAS :
NA
Molecular Formula : C29H37NO8
Molecular Weight : 527.61
(R)-1-((11bS,12S,14aR)-13-Hydroxy-2,3,5,6,11b,12-hexahydro-1H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-12-yl) 4-methyl 2-hydroxy-2-(4-methylpent-4-en-1-yl)succinate
(R)-1-((11bS,12S,14aR)-13-Hydroxy-2,3,5,6,11b,12-hexahydro-1H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-12-yl) 4-methyl 2-hydroxy-2-(4-methylpent-4-en-1-yl)succinate
Catalogue No.:PA 15 39580
CAS :
NA
Molecular Formula : C28H35NO8
Molecular Weight : 513.58
(R)-3-Hydroxy-3-((((11bS,12S,14aR)-13-methoxy-2,3,5,6,11b,12-hexahydro-1H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-12-yl)oxy)carbonyl)-7-methyloct-7-enoic Acid
(R)-3-Hydroxy-3-((((11bS,12S,14aR)-13-methoxy-2,3,5,6,11b,12-hexahydro-1H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-12-yl)oxy)carbonyl)-7-methyloct-7-enoic Acid
Catalogue No.:PA 15 39590
CAS :
NA
Molecular Formula : C28H35NO8
Molecular Weight : 513.58
(R)-1-((11bS,12S,14aR)-13-Hydroxy-2,3,5,6,11b,12-hexahydro-1H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-12-yl) 4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)succinate
(R)-1-((11bS,12S,14aR)-13-Hydroxy-2,3,5,6,11b,12-hexahydro-1H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-12-yl) 4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)succinate
Catalogue No.:PA 15 0391000
CAS :
NA
Molecular Formula : C28H37NO9
Molecular Weight : 531.59
