Orforglipron and its Impurities
Orforglipron is under investigation in clinical trial NCT06010004 . Reference standards of Orforglipron API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
5-((S)-2,2-Dimethyltetrahydro-2H-pyran-4-yl)-1-((1S,2S)-2-methyl-1-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)cyclopropyl)-1H-indole-2-carboxylic Acid
5-((S)-2,2-Dimethyltetrahydro-2H-pyran-4-yl)-1-((1S,2S)-2-methyl-1-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)cyclopropyl)-1H-indole-2-carboxylic Acid
Catalogue No.:PA 15 1241000
CAS :
2212021-83-3
Molecular Formula : C22H25N3O5
Molecular Weight : 411.46
tert-Butyl (S)-2-(4-fluoro-3,5-dimethylphenyl)-3-((S)-4-hydroxy-2-oxoimidazolidin-1-yl)-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate
tert-Butyl (S)-2-(4-fluoro-3,5-dimethylphenyl)-3-((S)-4-hydroxy-2-oxoimidazolidin-1-yl)-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate
Catalogue No.:PA 15 1241003
CAS :
NA
Molecular Formula : C23H30FN5O4
Molecular Weight : 459.52
tert-Butyl (S)-3-amino-2-(3,5-dimethylphenyl)-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate
tert-Butyl (S)-3-amino-2-(3,5-dimethylphenyl)-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate
Catalogue No.:PA 15 1241007
CAS :
NA
Molecular Formula : C20H28N4O2
Molecular Weight : 356.47
tert-Butyl (S)-3-amino-2-(4-chloro-3,5-dimethylphenyl)-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate
tert-Butyl (S)-3-amino-2-(4-chloro-3,5-dimethylphenyl)-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate
Catalogue No.:PA 15 1241008
CAS :
NA
Molecular Formula : C20H27ClN4O2
Molecular Weight : 390.91
tert-Butyl (S)-2-(4-fluoro-3,5-dimethylphenyl)-3-((R)-4-hydroxy-2-oxoimidazolidin-1-yl)-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate
tert-Butyl (S)-2-(4-fluoro-3,5-dimethylphenyl)-3-((R)-4-hydroxy-2-oxoimidazolidin-1-yl)-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate
Catalogue No.:PA 15 1241011
CAS :
NA
Molecular Formula : C23H30FN5O4
Molecular Weight : 459.52
tert-Butyl (S)-3-(3-(tert-butoxycarbonyl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl)-2-(4-fluoro-3,5-dimethylphenyl)-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate
tert-Butyl (S)-3-(3-(tert-butoxycarbonyl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl)-2-(4-fluoro-3,5-dimethylphenyl)-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate
Catalogue No.:PA 15 1241012
CAS :
NA
Molecular Formula : C28H36FN5O5
Molecular Weight : 541.62
tert-Butyl (S)-2-(3,5-dimethylphenyl)-4-methyl-3-(2-oxo-2,3-dihydro-1H-imidazol-1-yl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate
tert-Butyl (S)-2-(3,5-dimethylphenyl)-4-methyl-3-(2-oxo-2,3-dihydro-1H-imidazol-1-yl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate
Catalogue No.:PA 15 1241013
CAS :
NA
Molecular Formula : C23H29N5O3
Molecular Weight : 423.52
(S)-1-(2-(4-Fluoro-3,5-dimethylphenyl)-4-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-3-yl)-1,3-dihydro-2H-imidazol-2-one
(S)-1-(2-(4-Fluoro-3,5-dimethylphenyl)-4-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-3-yl)-1,3-dihydro-2H-imidazol-2-one
Catalogue No.:PA 15 1241014
CAS :
2212021-62-8
Molecular Formula : C18H20FN5O
Molecular Weight : 341.39
tert-Butyl (R)-2-(4-fluoro-3,5-dimethylphenyl)-4-methyl-3-(2-oxo-2,3-dihydro-1H-imidazol-1-yl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate
tert-Butyl (R)-2-(4-fluoro-3,5-dimethylphenyl)-4-methyl-3-(2-oxo-2,3-dihydro-1H-imidazol-1-yl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate
Catalogue No.:PA 15 1241015
CAS :
NA
Molecular Formula : C23H28FN5O3
Molecular Weight : 441.51
