osimertinib and its Impurities
Osimertinib is used to treat locally advanced or metastatic non-small-cell lung cancer. It is a third-generation epidermal growth factor receptor tyrosine kinase inhibitor.Reference standards of Osimertinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-3-((2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)propanamide
N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-3-((2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)propanamide
Catalogue No.:PA 15 0511001
CAS :
2919324-15-3
Molecular Formula : C53H64N14O3
Molecular Weight : 945.19


N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-N-(3-((2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)-3-oxopropyl)acrylamide
N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-N-(3-((2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)-3-oxopropyl)acrylamide
Catalogue No.:PA 15 0511002
CAS :
NA
Molecular Formula : C56H66N14O4
Molecular Weight : 999.24


N-(2-((2-Acrylamido-5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)(methyl)amino)ethyl)-3-((2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)-N,N-dimethyl-3-oxopropan-1-aminium Chloride
N-(2-((2-Acrylamido-5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)(methyl)amino)ethyl)-3-((2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)-N,N-dimethyl-3-oxopropan-1-aminium Chloride
Catalogue No.:PA 15 0511003
CAS :
NA
Molecular Formula : C56H67ClN14O4
Molecular Weight : 1035.7


N-(5-((4-(1H-Indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide
N-(5-((4-(1H-Indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide
Catalogue No.:PA 15 0511004
CAS :
1421373-98-9
Molecular Formula : C27H31N7O2
Molecular Weight : 485.59


5-Methoxy-N1,N1-dimethyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)benzene-1,2,4-triamine hydrochloride
5-Methoxy-N1,N1-dimethyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)benzene-1,2,4-triamine hydrochloride
Catalogue No.:PA 15 0511005
CAS :
2044702-55-6
Molecular Formula : C22H25ClN6O
Molecular Weight : 424.93


2-Methoxy-N4,N4-dimethyl-N1-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)-5-nitrobenzene-1,4-diamine
2-Methoxy-N4,N4-dimethyl-N1-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)-5-nitrobenzene-1,4-diamine
Catalogue No.:PA 15 0511006
CAS :
1820891-36-8
Molecular Formula : C22H22N6O3
Molecular Weight : 418.46


 N-(4-Methoxy-2-(methyl(2-(methylamino)ethyl)amino)-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide
N-(4-Methoxy-2-(methyl(2-(methylamino)ethyl)amino)-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide
Catalogue No.:PA 15 0511007
CAS :
1421373-99-0
Molecular Formula : C27H31N7O2
Molecular Weight : 485.59

![N4-(4-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1- PA STI 088985](https://www.pharmaffiliates.com/pimages/PASTI088985.jpg)
N4-(4-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)pyrimidin-2-yl)-5-methoxy-N1-methyl-N1-(2-(methyl(methyl-d3)amino)ethyl)benzene-1,2,4-triamine
N4-(4-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)pyrimidin-2-yl)-5-methoxy-N1-methyl-N1-(2-(methyl(methyl-d3)amino)ethyl)benzene-1,2,4-triamine
Catalogue No.:PA STI 088985
CAS :
2211116-74-2
Molecular Formula : C27H30D3N7O
Molecular Weight : 474.63

![N-(5-((4-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin PA STI 088986](https://www.pharmaffiliates.com/pimages/PASTI088986.jpg)
N-(5-((4-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(2-(methyl(methyl-d3)amino)ethyl)amino)phenyl)acrylamide
N-(5-((4-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)pyrimidin-2-yl)amino)-4-methoxy-2-(methyl(2-(methyl(methyl-d3)amino)ethyl)amino)phenyl)acrylamide
Catalogue No.:PA STI 088986
CAS :
2211116-92-4
Molecular Formula : C30H32D3N7O2
Molecular Weight : 528.68


N-(2-(Dimethylamino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide
N-(2-(Dimethylamino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide
Catalogue No.:PA 15 0511008
CAS :
2044702-39-6
Molecular Formula : C25H26N6O2
Molecular Weight : 442.52


N-(2-((2-acrylamido-5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)(methyl)amino)ethyl)-3-((2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)-N,N-dimethyl-3-oxopropan-1-aminium
N-(2-((2-acrylamido-5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)(methyl)amino)ethyl)-3-((2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)-N,N-dimethyl-3-oxopropan-1-aminium
Catalogue No.:PA 15 0511010
CAS :
2564638-97-5
Molecular Formula : C56H67N14O4
Molecular Weight : 1000.25


N-(5-((4-(1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide hydrochloride
N-(5-((4-(1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide hydrochloride
Catalogue No.:PA 15 0511011
CAS :
2469006-57-1
Molecular Formula : C27H32ClN7O2
Molecular Weight : 522.05


2-((2-Acrylamido-5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)(methyl)amino)-N,N-dimethyl-N-((2-oxopyrrolidin-1-yl)methyl)ethan-1-aminium chloride
2-((2-Acrylamido-5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)(methyl)amino)-N,N-dimethyl-N-((2-oxopyrrolidin-1-yl)methyl)ethan-1-aminium chloride
Catalogue No.:PA 15 0511012
CAS :
2411395-25-8
Molecular Formula : C33H41ClN8O3
Molecular Weight : 633.19

![N4-(4-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1- PA 15 0511013](https://www.pharmaffiliates.com/pimages/PA150511013.jpg)
N4-(4-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)pyrimidin-2-yl)-N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methylbenzene-1,2,4-triamine
N4-(4-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)pyrimidin-2-yl)-N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methylbenzene-1,2,4-triamine
Catalogue No.:PA 15 0511013
CAS :
1825290-88-7
Molecular Formula : C27H33N7O
Molecular Weight : 471.61

![N-(5-((4-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin PA 15 0511015](https://www.pharmaffiliates.com/pimages/PA150511015.jpg)
N-(5-((4-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide
N-(5-((4-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide
Catalogue No.:PA 15 0511015
CAS :
1825287-91-9
Molecular Formula : C30H35N7O2
Molecular Weight : 525.66


2-((2-Acrylamido-5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)(methyl)amino)-N,N-dimethylethan-1-amine oxide
2-((2-Acrylamido-5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)(methyl)amino)-N,N-dimethylethan-1-amine oxide
Catalogue No.:PA 15 0511016
CAS :
1975982-94-5
Molecular Formula : C28H33N7O3
Molecular Weight : 515.62


3-Chloro-N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)propanamide
3-Chloro-N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)propanamide
Catalogue No.:PA 15 0511021
CAS :
1421373-36-5
Molecular Formula : C28H34ClN7O2
Molecular Weight : 536.08


N1-(2-(Dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)benzene-1,2,4-triamine
N1-(2-(Dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)benzene-1,2,4-triamine
Catalogue No.:PA 15 0511022
CAS :
1421372-66-8
Molecular Formula : C25H31N7O
Molecular Weight : 445.57


N1,N5-Bis(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-2-methylenepentanediamide
N1,N5-Bis(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-2-methylenepentanediamide
Catalogue No.:PA 15 0511023
CAS :
2945220-41-5
Molecular Formula : C56H66N14O4
Molecular Weight : 999.24


1-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)azetidin-2-one
1-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)azetidin-2-one
Catalogue No.:PA 15 0511028
CAS :
NA
Molecular Formula : C28H33N7O2
Molecular Weight : 499.62


N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide
N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide
Catalogue No.:PAI 15 051001
CAS :
NA
Molecular Formula : C28H33N7O2
Molecular Weight : 499.62


3-((2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)propanoic acid
3-((2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)propanoic acid
Catalogue No.:PAI 15 051002
CAS :
NA
Molecular Formula : C28H35N7O3
Molecular Weight : 517.63


N-(4-Methoxy-2-(methyl(2-(methylamino)ethyl)amino)-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide Hydrochloride
N-(4-Methoxy-2-(methyl(2-(methylamino)ethyl)amino)-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide Hydrochloride
Catalogue No.:PA 15 0511032
CAS :
2309762-40-9
Molecular Formula : C27H32ClN7O2
Molecular Weight : 522.05


N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-nitroso-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide
N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-nitroso-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide
Catalogue No.:PA 15 0511033
CAS :
NA
Molecular Formula : C27H30N8O3
Molecular Weight : 514.59


N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)(nitroso)amino)phenyl)acrylamide
N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)(nitroso)amino)phenyl)acrylamide
Catalogue No.:PA 15 0511034
CAS :
NA
Molecular Formula : C28H32N8O3
Molecular Weight : 528.62


N-(2-((2-(Dimethylamino)ethyl)(nitroso)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide
N-(2-((2-(Dimethylamino)ethyl)(nitroso)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide
Catalogue No.:PA 15 0511035
CAS :
NA
Molecular Formula : C27H30N8O3
Molecular Weight : 514.59


N-(4-Methoxy-2-(methyl(2-(methyl(nitroso)amino)ethyl)amino)-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide
N-(4-Methoxy-2-(methyl(2-(methyl(nitroso)amino)ethyl)amino)-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide
Catalogue No.:PA 15 0511036
CAS :
NA
Molecular Formula : C27H30N8O3
Molecular Weight : 514.59


N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-N-(3-((2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)-3-oxopropyl)acrylamide
N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-N-(3-((2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)-3-oxopropyl)acrylamide
Catalogue No.:PA 15 0511039
CAS :
2919324-18-6
Molecular Formula : C56H66N14O4
Molecular Weight : 999.24


Ethyl (3R,4R,5S)-5-(allylamino)-4-(N-(tert-butyl)acetamido)-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate
Ethyl (3R,4R,5S)-5-(allylamino)-4-(N-(tert-butyl)acetamido)-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate
Catalogue No.:PA 15 0511042
CAS :
2765792-94-5
Molecular Formula : C23H40N2O4
Molecular Weight : 408.58