palonosetron and its Impurities
Palonosetron is used in the prevention and treatment of chemotherapy-induced nausea and vomiting.Reference standards of Palonosetron API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

![(3aR)-2-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4, PA 16 80560](https://www.pharmaffiliates.com/pimages/PA1680560.jpg)
(3aR)-2-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one Hydrochloride
(3aR)-2-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one Hydrochloride
Catalogue No.:PA 16 80560
CAS :
135729-75-8
Molecular Formula : C19H25ClN2O
Molecular Weight : 332.87

![(3S)-N-[[(1S)-1,2,3,4-Tetrahydro-1-naphthalenyl]me PA STI 082260](https://www.pharmaffiliates.com/pimages/PASTI082260.jpg)
(3S)-N-[[(1S)-1,2,3,4-Tetrahydro-1-naphthalenyl]methyl]-1-azabicyclo[2.2.2]octan-3-amine-d3
(3S)-N-[[(1S)-1,2,3,4-Tetrahydro-1-naphthalenyl]methyl]-1-azabicyclo[2.2.2]octan-3-amine-d3
Catalogue No.:PA STI 082260
CAS :
1329499-39-9
Molecular Formula : C18H23D3N2
Molecular Weight : 273.43


Palonosetron Enantiomer ((3aR)-2-[(3R)-Quinuclidin-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquin (1492211)
Palonosetron Enantiomer ((3aR)-2-[(3R)-Quinuclidin-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquin (1492211)
Catalogue No.:PA USP1492211
CAS :
135729-75-8
Molecular Formula : NA
Molecular Weight : NA


Palonosetron Related Compound A ((3aS)-1-Oxo-2-[(3S)-quinuclidin-3-yl]-2,3,3a,4,5,6-hexahydro-1H-be (1492222)
Palonosetron Related Compound A ((3aS)-1-Oxo-2-[(3S)-quinuclidin-3-yl]-2,3,3a,4,5,6-hexahydro-1H-be (1492222)
Catalogue No.:PA USP1492222
CAS :
813425-83-1
Molecular Formula : NA
Molecular Weight : NA


Palonosetron Related Compound B ((3S)-3-(1-Oxo-5,6-dihydro-1H-benzo[de]isoquinolin-2(4H)-yl)quinucl (1492233)
Palonosetron Related Compound B ((3S)-3-(1-Oxo-5,6-dihydro-1H-benzo[de]isoquinolin-2(4H)-yl)quinucl (1492233)
Catalogue No.:PA USP1492233
CAS :
1021456-82-5
Molecular Formula : NA
Molecular Weight : NA


Palonosetron Related Compound C ((3aS)-2-[(3R)-Quinuclidin-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de (1492244)
Palonosetron Related Compound C ((3aS)-2-[(3R)-Quinuclidin-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de (1492244)
Catalogue No.:PA USP1492244
CAS :
135729-76-9
Molecular Formula : NA
Molecular Weight : NA


Palonosetron Related Compound D ((3aR)-2-[(3S)-Quinuclidin-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de (1492255)
Palonosetron Related Compound D ((3aR)-2-[(3S)-Quinuclidin-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de (1492255)
Catalogue No.:PA USP1492255
CAS :
135755-51-0
Molecular Formula : NA
Molecular Weight : NA


Palonosetron Related Compound E (2-[(3S)-Quinuclidin-3-yl]-2,4,5,6-tetrahydro-1H-benzo[de]isoquinol (1492266)
Palonosetron Related Compound E (2-[(3S)-Quinuclidin-3-yl]-2,4,5,6-tetrahydro-1H-benzo[de]isoquinol (1492266)
Catalogue No.:PA USP1492266
CAS :
135729-55-4
Molecular Formula : NA
Molecular Weight : NA

![1H-Benz[de]isoquinoline, 2-(3R)-1-azabicyclo[2.2.2 PA 69 0161000](https://www.pharmaffiliates.com/pimages/PA690161000.jpg)
1H-Benz[de]isoquinoline, 2-(3R)-1-azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-, (3aR)-rel
1H-Benz[de]isoquinoline, 2-(3R)-1-azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-, (3aR)-rel
Catalogue No.:PA 69 0161000
CAS :
1796933-62-4
Molecular Formula : C19H26N2
Molecular Weight : 282.43


1-Naphthalenecarboxamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-1,2,3,4-tetrahydro-, (1R)-rel
1-Naphthalenecarboxamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-1,2,3,4-tetrahydro-, (1R)-rel
Catalogue No.:PA 69 0161001
CAS :
2216755-75-6
Molecular Formula : C18H24N2O
Molecular Weight : 284.4


(S)-8-((((R)-Quinuclidin-3-yl)amino)methyl)-5,6,7,8-tetrahydronaphthalene-1-carboxylic Acid
(S)-8-((((R)-Quinuclidin-3-yl)amino)methyl)-5,6,7,8-tetrahydronaphthalene-1-carboxylic Acid
Catalogue No.:PA 69 0161002
CAS :
2407763-12-4
Molecular Formula : C19H26N2O2
Molecular Weight : 314.43

![1-Azabicyclo[2.2.2]octan-3-amine, N-[[(1R)-1,2,3, PA 69 0161003](https://www.pharmaffiliates.com/pimages/PA690161003.jpg)
1-Azabicyclo[2.2.2]octan-3-amine, N-[[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]methyl]-, (3S)-rel
1-Azabicyclo[2.2.2]octan-3-amine, N-[[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]methyl]-, (3S)-rel
Catalogue No.:PA 69 0161003
CAS :
2216755-70-1
Molecular Formula : C18H26N2
Molecular Weight : 270.42


(3aS)-5,6-Dihydroxy-2-((S)-quinuclidin-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one
(3aS)-5,6-Dihydroxy-2-((S)-quinuclidin-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one
Catalogue No.:PA 69 0161005
CAS :
NA
Molecular Formula : C19H24N2O3
Molecular Weight : 328.41


(3S)-3-((3aS)-6-Hydroxy-1-oxo-3a,4,5,6-tetrahydro-1H-benzo[de]isoquinolin-2(3H)-yl)quinuclidine 1-oxide
(3S)-3-((3aS)-6-Hydroxy-1-oxo-3a,4,5,6-tetrahydro-1H-benzo[de]isoquinolin-2(3H)-yl)quinuclidine 1-oxide
Catalogue No.:PA 69 0161008
CAS :
NA
Molecular Formula : C19H24N2O3
Molecular Weight : 328.41


(S)-8-((((S)-Quinuclidin-3-yl)amino)methyl)-5,6,7,8-tetrahydronaphthalene-1-carboxylic Acid
(S)-8-((((S)-Quinuclidin-3-yl)amino)methyl)-5,6,7,8-tetrahydronaphthalene-1-carboxylic Acid
Catalogue No.:PA 69 0161009
CAS :
2407763-21-5
Molecular Formula : C19H26N2O2
Molecular Weight : 314.43


1-Naphthalenecarboxylic acid, 8-[[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]methyl]-5,6,7,8-tetrahydro-, (8R)-rel
1-Naphthalenecarboxylic acid, 8-[[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]methyl]-5,6,7,8-tetrahydro-, (8R)-rel
Catalogue No.:PA 69 0161010
CAS :
2125941-92-4
Molecular Formula : C19H26N2O2
Molecular Weight : 314.43


(S)-8-((Nitroso((1S,3R,4S)-quinuclidin-3-yl)amino)methyl)-5,6,7,8-tetrahydronaphthalene-1-carboxylic Acid
(S)-8-((Nitroso((1S,3R,4S)-quinuclidin-3-yl)amino)methyl)-5,6,7,8-tetrahydronaphthalene-1-carboxylic Acid
Catalogue No.:PA 69 0161015
CAS :
NA
Molecular Formula : C19H25N3O3
Molecular Weight : 343.43