pimecrolimus and its Impurities
An ascomycin macrolactam derivative, Pimecrolimus is an immunomodulating agent. It belongs to the class of calcineurin inhibitors and used in the treatment of dermatitis and other inflammatory skin infections.Reference standards of Pimecrolimus API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
(4R,5R,7S,8R,9S,11S,13E,15R,17E,19R,20S,23R)-20-((E)-1-((1R,3R,4R)-4-Chloro-3-methoxycyclohexyl)prop-1-en-2-yl)-15-ethyl-4-hydroxy-7,9-dimethoxy-5,11,13,19-tetramethyl-21,28-dioxa-1-azatricyclo[21.3.1.14,8]octacosa-13,17-diene-2,3,16,22-tetraone
(4R,5R,7S,8R,9S,11S,13E,15R,17E,19R,20S,23R)-20-((E)-1-((1R,3R,4R)-4-Chloro-3-methoxycyclohexyl)prop-1-en-2-yl)-15-ethyl-4-hydroxy-7,9-dimethoxy-5,11,13,19-tetramethyl-21,28-dioxa-1-azatricyclo[21.3.1.14,8]octacosa-13,17-diene-2,3,16,22-tetraone
Catalogue No.:PA 16 69510
CAS :
NA
Molecular Formula : C43H66ClNO10
Molecular Weight : 792.45
(3S,4R,5R,8R,12S,14S,15R,16S,18R,19S,26aS,E)-3-((E)-1-((1R,3R,4S)-4-Chloro-3-methoxycyclohexyl)prop-1-en-2-yl)-8-ethyl-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1]oxa[4]azacyclotricosine-1,7,20,21(4H,23H)-tetraone
(3S,4R,5R,8R,12S,14S,15R,16S,18R,19S,26aS,E)-3-((E)-1-((1R,3R,4S)-4-Chloro-3-methoxycyclohexyl)prop-1-en-2-yl)-8-ethyl-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1]oxa[4]azacyclotricosine-1,7,20,21(4H,23H)-tetraone
Catalogue No.:PA 16 0691004
CAS :
NA
Molecular Formula : C43H68ClNO11
Molecular Weight : 810.46
