ponatinib and its Impurities
A multi-targeted tyrosine-kinase inhibitor, Ponatinib is used in treating chronic myeloid leukemia. Shows antiangiogenic and antineoplastic activities.Reference standards of Ponatinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


N-(4-Formyl-3-(trifluoromethyl)phenyl)-3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide
N-(4-Formyl-3-(trifluoromethyl)phenyl)-3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide
Catalogue No.:PA 16 91530
CAS :
1638193-92-6
Molecular Formula : C24H15F3N4O2
Molecular Weight : 448.4


3-Ethynyl-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
3-Ethynyl-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
Catalogue No.:PA 16 91540
CAS :
957147-18-1
Molecular Formula : C23H24F3N3O
Molecular Weight : 415.45

![3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N PA 16 91560](https://www.pharmaffiliates.com/pimages/PA1691560.jpg)
3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl)benzamide
3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl)benzamide
Catalogue No.:PA 16 91560
CAS :
943319-87-7
Molecular Formula : C28H25F3N6O
Molecular Weight : 518.53


3,3-(Buta-1,3-diyne-1,4-diyl)bis(4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide);
3,3-(Buta-1,3-diyne-1,4-diyl)bis(4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide);
Catalogue No.:PA 16 0911001
CAS :
2097674-16-1
Molecular Formula : C46H46F6N6O2
Molecular Weight : 828.9

![3,5-bis(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-met PA 16 0911005](https://www.pharmaffiliates.com/pimages/PA160911005.jpg)
3,5-bis(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
3,5-bis(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
Catalogue No.:PA 16 0911005
CAS :
NA
Molecular Formula : C37H30F3N9O
Molecular Weight : 673.7

![3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N PA 16 0911006](https://www.pharmaffiliates.com/pimages/PA160911006.jpg)
3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-nitrosopiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-nitrosopiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
Catalogue No.:PA 16 0911006
CAS :
NA
Molecular Formula : C28H24F3N7O2
Molecular Weight : 547.54