Pralsetinib and its Impurities
Pralsetinib, sold under the brand name Gavreto, is a medication approved RET mutation-positive medullary thyroid cancer and RET fusion-positive differentiated thyroid cancer refractory to radioactive iodine therapy. Reference standards of Pralsetinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


Methyl cis-1-methoxy-4-[4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]cyclohexanecarboxylate
Methyl cis-1-methoxy-4-[4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]cyclohexanecarboxylate
Catalogue No.:PA 16 3771001
CAS :
2778223-51-9
Molecular Formula : C18H25N5O3
Molecular Weight : 359.43


cis-1-Methoxy-4-[4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]cyclohexanecarboxylic Acid
cis-1-Methoxy-4-[4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]cyclohexanecarboxylic Acid
Catalogue No.:PA 16 3771002
CAS :
2778223-52-0
Molecular Formula : C17H23N5O3
Molecular Weight : 345.4