prucalopride and its Impurities
A serotonin (5-HT4) receptor agonist, Prucalopride is used for the treatment of chronic constipation. Prucalopride belongs to dihydro-benzofuran-carboxamide class and helps in stimulating colonic mass movements.Reference standards of Prucalopride API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


4-(4-Amino-5-chloro-2,3-dihydrobenzofuran-7-carboxamido)-1-(3-methoxypropyl)piperidine 1-oxide
4-(4-Amino-5-chloro-2,3-dihydrobenzofuran-7-carboxamido)-1-(3-methoxypropyl)piperidine 1-oxide
Catalogue No.:PA 43 35560
CAS :
1900715-98-1
Molecular Formula : C18H26ClN3O4
Molecular Weight : 383.87


4-Amino-5-chloro-N-(1-(3-hydroxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide
4-Amino-5-chloro-N-(1-(3-hydroxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide
Catalogue No.:PA 43 35590
CAS :
1599434-55-5
Molecular Formula : C17H24ClN3O3
Molecular Weight : 353.84


4-Acetamido-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide
4-Acetamido-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide
Catalogue No.:PA 43 35600
CAS :
2181480-01-1
Molecular Formula : C20H28ClN3O4
Molecular Weight : 409.91


5-chloro-4-(((2S,3R,4R,5S,6S)-3,4-dihydroxy-6-methoxy-5-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)amino)-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide
5-chloro-4-(((2S,3R,4R,5S,6S)-3,4-dihydroxy-6-methoxy-5-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)amino)-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide
Catalogue No.:PA 43 0351001
CAS :
NA
Molecular Formula : C30H46ClN3O13
Molecular Weight : 692.16


5-chloro-4-(((3S,4S,5R)-3-hydroxy-2,5-bis(hydroxymethyl)-4-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydrofuran-2-yl)amino)-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide
5-chloro-4-(((3S,4S,5R)-3-hydroxy-2,5-bis(hydroxymethyl)-4-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydrofuran-2-yl)amino)-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide
Catalogue No.:PA 43 0351002
CAS :
2245785-75-3
Molecular Formula : C30H46ClN3O13
Molecular Weight : 692.16


4-amino-5-chloro-N-((3S,4S,5R)-3-hydroxy-2,5-bis(hydroxymethyl)-4-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydrofuran-2-yl)-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide
4-amino-5-chloro-N-((3S,4S,5R)-3-hydroxy-2,5-bis(hydroxymethyl)-4-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydrofuran-2-yl)-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide
Catalogue No.:PA 43 0351003
CAS :
2245785-74-2
Molecular Formula : C30H46ClN3O13
Molecular Weight : 692.16


4-(4-Amino-5-chloro-2,3-dihydrobenzofuran-7-carboxamido)-3,5-dihydroxy-1-(3-methoxypropyl)piperidine 1-oxide
4-(4-Amino-5-chloro-2,3-dihydrobenzofuran-7-carboxamido)-3,5-dihydroxy-1-(3-methoxypropyl)piperidine 1-oxide
Catalogue No.:PA 43 0351006
CAS :
1900715-95-8
Molecular Formula : C18H26ClN3O6
Molecular Weight : 415.87


Tert-Butyl 4-(4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxamido)piperidine-1-carboxylate
Tert-Butyl 4-(4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxamido)piperidine-1-carboxylate
Catalogue No.:PAI 43 035001
CAS :
2124248-66-2
Molecular Formula : C19H26ClN3O4
Molecular Weight : 395.88


5-Chloro-4-(((2R,3S,4R,6S)-3,4-dihydroxy-6-(hydroxymethyl)-5-(((2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)amino)-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide
5-Chloro-4-(((2R,3S,4R,6S)-3,4-dihydroxy-6-(hydroxymethyl)-5-(((2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)amino)-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide
Catalogue No.:PA 43 0351017
CAS :
NA
Molecular Formula : C30H46ClN3O13
Molecular Weight : 692.16


4-Amino-5-chloro-2-hydroxy-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide
4-Amino-5-chloro-2-hydroxy-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide
Catalogue No.:PA 43 0351019
CAS :
1900715-97-0
Molecular Formula : C18H26ClN3O4
Molecular Weight : 383.87


4-(4-Amino-5-chloro-2,3-dihydrobenzofuran-7-carboxamido)-1-(3-methoxypropyl)-1,2,3,4-tetrahydropyridine 1-oxide
4-(4-Amino-5-chloro-2,3-dihydrobenzofuran-7-carboxamido)-1-(3-methoxypropyl)-1,2,3,4-tetrahydropyridine 1-oxide
Catalogue No.:PA 43 0351021
CAS :
1900715-99-2
Molecular Formula : C18H24ClN3O4
Molecular Weight : 381.86


3-(4-(4-Amino-5-chloro-2,3-dihydrobenzofuran-7-carboxamido)piperidin-1-yl)propyl 4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylate
3-(4-(4-Amino-5-chloro-2,3-dihydrobenzofuran-7-carboxamido)piperidin-1-yl)propyl 4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylate
Catalogue No.:PA 43 0351022
CAS :
NA
Molecular Formula : C26H30Cl2N4O5
Molecular Weight : 549.45