Regorafenib-impurities | Pharmaffiliates

regorafenib and its Impurities

A multikinase inhibitor, Regorafenib is used in the treatment of metastatic colorectal cancer and advanced gastrointestinal stromal tumors. Shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition.Reference standards of Regorafenib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

Displaying 21 results for regorafenib Impurities
PA 18 49000

Regorafenib - API

Regorafenib


  • Catalogue No.:PA 18 49000

  • CAS :

    755037-03-7

  • Molecular Formula : C21H15ClF4N4O3

  • Molecular Weight : 482.82

PA 18 49510

Regorafenib N-Oxide

Regorafenib N-Oxide


  • Catalogue No.:PA 18 49510

  • CAS :

    835621-11-9

  • Molecular Formula : C21H15ClF4N4O4

  • Molecular Weight : 498.81

PA 18 49520

4-(4-Amino-3-fluorophenoxy)-N-(2-fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)picolinamide

4-(4-Amino-3-fluorophenoxy)-N-(2-fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)picolinamide


  • Catalogue No.:PA 18 49520

  • CAS :

    NA

  • Molecular Formula : C25H19F2N5O4

  • Molecular Weight : 491.45

PA 18 49530

Hydroxyregorafenib

Hydroxyregorafenib


  • Catalogue No.:PA 18 49530

  • CAS :

    1343498-71-4

  • Molecular Formula : C21H15ClF4N4O4

  • Molecular Weight : 498.81

PA 18 49540

4-Dechloro-2-chloro-Regorafenib

4-Dechloro-2-chloro-Regorafenib


  • Catalogue No.:PA 18 49540

  • CAS :

    NA

  • Molecular Formula : C21H15ClF4N4O3

  • Molecular Weight : 482.82

PA 18 49550

Regorafenib - Impurity C

4-(3-Fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)amino)phenoxy)-N-methylpicolinamide


  • Catalogue No.:PA 18 49550

  • CAS :

    NA

  • Molecular Formula : C20H18FN5O3

  • Molecular Weight : 395.39

PA 18 49560

Regorafenib - Impurity D

4,4'-(((Carbonylbis(azanediyl))bis(3-fluoro-4,1-phenylene))bis(oxy))bis(N-methylpicolinamide)


  • Catalogue No.:PA 18 49560

  • CAS :

    NA

  • Molecular Formula : C27H22F2N6O5

  • Molecular Weight : 548.5

PA 18 49570

4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinic Acid

4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinic Acid


  • Catalogue No.:PA 18 49570

  • CAS :

    1187945-05-6

  • Molecular Formula : C20H12ClF4N3O4

  • Molecular Weight : 469.77

PA 18 49580

N-Desmethyl Regorafenib

N-Desmethyl Regorafenib


  • Catalogue No.:PA 18 49580

  • CAS :

    1343498-72-5

  • Molecular Formula : C20H13ClF4N4O3

  • Molecular Weight : 468.79

PA 18 49590

4-Amino-3-fluorophenol

4-Amino-3-fluorophenol


  • Catalogue No.:PA 18 49590

  • CAS :

    399-95-1

  • Molecular Formula : C6H6FNO

  • Molecular Weight : 127.12

PA 18 49600

(4-Chloro-3-(trifluoromethyl)phenyl)carbamic Acid

(4-Chloro-3-(trifluoromethyl)phenyl)carbamic Acid


  • Catalogue No.:PA 18 49600

  • CAS :

    NA

  • Molecular Formula : C8H5ClF3NO2

  • Molecular Weight : 239.58

PA 18 49610

(2-Fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)carbamic Acid

(2-Fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)carbamic Acid


  • Catalogue No.:PA 18 49610

  • CAS :

    NA

  • Molecular Formula : C14H12FN3O4

  • Molecular Weight : 305.26

PA 18 49620

4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinic Acid

4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinic Acid


  • Catalogue No.:PA 18 49620

  • CAS :

    1187945-05-6

  • Molecular Formula : C20H12ClF4N3O4

  • Molecular Weight : 469.77

PA 18 49630

Ethyl (2-Fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)carbamate

Ethyl (2-Fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)carbamate


  • Catalogue No.:PA 18 49630

  • CAS :

    NA

  • Molecular Formula : C16H16FN3O4

  • Molecular Weight : 333.31

PA 18 49640

Ethyl (4-chloro-3-(trifluoromethyl)phenyl)carbamate

Ethyl (4-chloro-3-(trifluoromethyl)phenyl)carbamate


  • Catalogue No.:PA 18 49640

  • CAS :

    18585-06-3

  • Molecular Formula : C10H9ClF3NO2

  • Molecular Weight : 267.63

PA 18 49010

Regorafenib - Impurity A

4-(4-Amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide


  • Catalogue No.:PA 18 49010

  • CAS :

    757251-39-1

  • Molecular Formula : C13H12FN3O2

  • Molecular Weight : 261.25

PA 18 0490050

Regorafenib - Impurity E

4-[4-[[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl]amino]-3-[4-[[[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl]amino]-3-fluorophenoxy]phenoxy]-N-methylpyridine-2-carboxamide


  • Catalogue No.:PA 18 0490050

  • CAS :

    NA

  • Molecular Formula : C35H23Cl2F7N6O5

  • Molecular Weight : 811.49

PA 18 0491000

N-Desmethyl Regorafenib N-Oxide (M5 Metabolite)

N-Desmethyl Regorafenib N-Oxide (M5 Metabolite)


  • Catalogue No.:PA 18 0491000

  • CAS :

    835621-12-0

  • Molecular Formula : C20H13ClF4N4O4

  • Molecular Weight : 484.79

PA 18 0491001

4-(3-Fluoro-4-(3-(3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide

4-(3-Fluoro-4-(3-(3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide


  • Catalogue No.:PA 18 0491001

  • CAS :

    NA

  • Molecular Formula : C21H16F4N4O3

  • Molecular Weight : 448.38

PA 18 0491002

4-(4-acetamido-3-fluorophenoxy)-N-methylpicolinamide

4-(4-acetamido-3-fluorophenoxy)-N-methylpicolinamide


  • Catalogue No.:PA 18 0491002

  • CAS :

    2141961-84-2

  • Molecular Formula : C15H14FN3O3

  • Molecular Weight : 303.29

PA STI 089099

Regorafenib D3

Regorafenib D3


  • Catalogue No.:PA STI 089099

  • CAS :

    1255386-16-3

  • Molecular Formula : C21H12D3ClF4N4O3

  • Molecular Weight : 485.84