regorafenib and its Impurities
A multikinase inhibitor, Regorafenib is used in the treatment of metastatic colorectal cancer and advanced gastrointestinal stromal tumors. Shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition.Reference standards of Regorafenib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
4-(4-Amino-3-fluorophenoxy)-N-(2-fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)picolinamide
4-(4-Amino-3-fluorophenoxy)-N-(2-fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)picolinamide
Catalogue No.:PA 18 49520
CAS :
2518234-85-8
Molecular Formula : C25H19F2N5O4
Molecular Weight : 491.45
Regorafenib - Impurity E
4-[4-[[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl]amino]-3-[4-[[[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl]amino]-3-fluorophenoxy]phenoxy]-N-methylpyridine-2-carboxamide
Catalogue No.:PA 18 0490050
CAS :
2098799-13-2
Molecular Formula : C35H23Cl2F7N6O5
Molecular Weight : 811.49
4,4'-((2-Fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)azanediyl)bis(N-methylpicolinamide)
4,4'-((2-Fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)azanediyl)bis(N-methylpicolinamide)
Catalogue No.:PA 18 0491004
CAS :
NA
Molecular Formula : C27H24FN7O4
Molecular Weight : 529.53
3-(4-Chloro-3-(trifluoromethyl)phenyl)-1-((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl)-1-(2-fluoro-4-hydroxyphenyl)urea
3-(4-Chloro-3-(trifluoromethyl)phenyl)-1-((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl)-1-(2-fluoro-4-hydroxyphenyl)urea
Catalogue No.:PA 18 0491012
CAS :
NA
Molecular Formula : C22H12Cl2F7N3O3
Molecular Weight : 570.24
4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenyl (4-chloro-3-(trifluoromethyl)phenyl)carbamate
4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenyl (4-chloro-3-(trifluoromethyl)phenyl)carbamate
Catalogue No.:PA 18 0491013
CAS :
2518416-73-2
Molecular Formula : C22H12Cl2F7N3O3
Molecular Weight : 570.24
1,3-Bis(4-chloro-3-(trifluoromethyl)phenyl)-1-((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl)urea
1,3-Bis(4-chloro-3-(trifluoromethyl)phenyl)-1-((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl)urea
Catalogue No.:PA 18 0491014
CAS :
NA
Molecular Formula : C23H11Cl3F9N3O2
Molecular Weight : 638.7