Ripasudil Monohydrochloride Dihydrate and its Impurities

Ripasudil Monohydrochloride Dihydrate (trade name Glanatec), a derivative of fasudil, is a rho kinase inhibitor drug (previously known as K-115). it used for the treatment of glaucoma and ocular hypertension. Reference standards of Ripasudil Monohydrochloride Dihydrate API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.