Risdiplam is an oral mRNA splicing modifier used in the treatment of spinal muscular atrophy (SMA). Reference standards of Risdiplam API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
Risdiplam
Catalogue No.:PA 18 1410000
CAS :
Molecular Formula : C22H23N7O
Molecular Weight : 401.47
tert-Butyl 7-(2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)-4,7-diazaspiro[2.5]octane-4-carboxylate
Catalogue No.:PA 18 1411000
Molecular Formula : C19H24N4O4
Molecular Weight : 372.43
tert-Butyl 7-(4-oxo-2-(tosyloxy)-4H-pyrido[1,2-a]pyrimidin-7-yl)-4,7-diazaspiro[2.5]octane-4-carboxylate
Catalogue No.:PA 18 1411001
Molecular Formula : C26H30N4O6S
Molecular Weight : 526.61
tert-Butyl 7-(2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)-4,7-diazaspiro[2.5]octane-4-carboxylate
Catalogue No.:PA 18 1411002
Molecular Formula : C27H31N7O3
Molecular Weight : 501.59
2-(2,8-Dimethylimidazo[1,2-b]pyridazin-6-yl)-7-fluoro-4H-pyrido[1,2-a]pyrimidin-4-one
Catalogue No.:PA 18 1411003
Molecular Formula : C16H12FN5O
Molecular Weight : 309.3
2-(2,8-Dimethylimidazo[1,2-b]pyridazin-6-yl)-7-(4-hydroxy-4,7-diazaspiro[2.5]octan-7-yl)-4H-pyrido[1,2-a]pyrimidin-4-one
Catalogue No.:PA 18 1411004
Molecular Formula : C22H23N7O2
Molecular Weight : 417.47
7-(2-(2,8-Dimethylimidazo[1,2-b]pyridazin-6-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)-4,7-diazaspiro[2.5]octane-4-carbaldehyde
Catalogue No.:PA 18 1411005
Molecular Formula : C23H23N7O2
Molecular Weight : 429.48
2-(2,8-Dimethylimidazo[1,2-b]pyridazin-6-yl)-7-hydroxy-4H-pyrido[1,2-a]pyrimidin-4-one
Catalogue No.:PA 18 1411006
Molecular Formula : C16H13N5O2
Molecular Weight : 307.31
7,7'-Di(4,7-diazaspiro[2.5]octan-7-yl)-4H,4'H-[2,2'-bipyrido[1,2-a]pyrimidine]-4,4'-dione
Catalogue No.:PA 18 1411007
Molecular Formula : C28H30N8O2
Molecular Weight : 510.6
7-(4,7-Diazaspiro[2.5]octan-7-yl)-2-(2,2',8,8'-tetramethyl-[3,6'-biimidazo[1,2-b]pyridazin]-6-yl)-4H-pyrido[1,2-a]pyrimidin-4-one
Catalogue No.:PA 18 1411008
Molecular Formula : C30H30N10O
Molecular Weight : 546.64
2-(2,8-Dimethylimidazo[1,2-b]pyridazin-6-yl)-7-(4-nitroso-4,7-diazaspiro[2.5]octan-7-yl)-4H-pyrido[1,2-a]pyrimidin-4-one
Catalogue No.:PA 18 1411009
Molecular Formula : C22H22N8O2
Molecular Weight : 430.47
tert-Butyl 4-nitroso-4,7-diazaspiro[2.5]octane-7-carboxylate
Catalogue No.:PA 18 1411010
Molecular Formula : C11H19N3O3
Molecular Weight : 241.29
7-(2-(2,8-Dimethylimidazo[1,2-b]pyridazin-6-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)-4,7-diazaspiro[2.5]octane 7-oxide
Catalogue No.:PA 18 1411011
3-Hydroxy-N-(2-((2-(8-methylimidazo[1,2-b]pyridazin-6-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)amino)ethyl)propanamide
Catalogue No.:PA 18 1411012
Molecular Formula : C20H21N7O3
Molecular Weight : 407.43
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