rivaroxaban and its Impurities
An anticoagulant drug used to prevent blood clots. A direct factor Xa inhibitor which is taken by mouth. An oxazolidinone derivative and structurally similar to anibiotic Linezolid.Reference standards of Rivaroxaban API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


3-((4-(5-((1,3-Dioxoisoindolin-2-yl)methyl)-2-oxooxazolidin-3-yl)phenyl)amino)propyl ((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)carbamate
3-((4-(5-((1,3-Dioxoisoindolin-2-yl)methyl)-2-oxooxazolidin-3-yl)phenyl)amino)propyl ((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)carbamate
Catalogue No.:PA 18 38630
CAS :
NA
Molecular Formula : C36H36N6O10
Molecular Weight : 712.71


4-(4-(((2-Oxo-3-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)oxazolidin-5-yl)methyl)amino)phenyl)morpholin-3-one
4-(4-(((2-Oxo-3-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)oxazolidin-5-yl)methyl)amino)phenyl)morpholin-3-one
Catalogue No.:PA 18 38650
CAS :
2809182-22-5
Molecular Formula : C28H31N5O8
Molecular Weight : 565.57


(S)-2-(2-((4-(5-((5-Chlorothiophene-2-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)amino)ethoxy)acetic Acid
(S)-2-(2-((4-(5-((5-Chlorothiophene-2-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)amino)ethoxy)acetic Acid
Catalogue No.:PA 18 38680
CAS :
931204-39-6
Molecular Formula : C19H20ClN3O6S
Molecular Weight : 453.9


5-Chloro-N-(1-hydroxy-2-((4-(3-oxomorpholino)phenyl)amino)ethyl)-N-(2-hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)thiophene-2-carboxamide
5-Chloro-N-(1-hydroxy-2-((4-(3-oxomorpholino)phenyl)amino)ethyl)-N-(2-hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)thiophene-2-carboxamide
Catalogue No.:PA 18 38750
CAS :
NA
Molecular Formula : C30H34ClN5O7S
Molecular Weight : 644.14


5-Chloro-N-((2S)-3-((3-(5-chlorothiophene-2-carboxamido)-2-hydroxypropyl)(4-(3-oxomorpholino)phenyl)amino)-2-hydroxypropyl)thiophene-2-carboxamide
5-Chloro-N-((2S)-3-((3-(5-chlorothiophene-2-carboxamido)-2-hydroxypropyl)(4-(3-oxomorpholino)phenyl)amino)-2-hydroxypropyl)thiophene-2-carboxamide
Catalogue No.:PA 18 38760
CAS :
NA
Molecular Formula : C26H28Cl2N4O6S2
Molecular Weight : 627.56


2-​[2-​[[4-​[(5S)​-​5-​[[[(5-Chloro-​2-​thienyl)​carbonyl]​amino]​methyl]​-​2-​oxo-​3-​oxazolidinyl]​phenyl]​amino]​ethoxy]​-acetic Acid Hydrochloride
2-​[2-​[[4-​[(5S)​-​5-​[[[(5-Chloro-​2-​thienyl)​carbonyl]​amino]​methyl]​-​2-​oxo-​3-​oxazolidinyl]​phenyl]​amino]​ethoxy]​-acetic Acid Hydrochloride
Catalogue No.:PA 18 38780
CAS :
931117-61-2
Molecular Formula : C19H21Cl2N3O6S
Molecular Weight : 490.36


Rivaroxaban - Impurity J
5-Chloro-N-[4-[(5S)-5-[(5-chlorothiophene-2-carboxamido)methyl]-2-oxo-1,3-oxazolidin-3- yl]phenyl]-N-[2-[2-oxo-2-[[[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5- yl]methyl]amino]ethoxy]ethyl]thiophene-2-carboxamide
Catalogue No.:PA 18 38790
CAS :
1632463-24-1
Molecular Formula : C38H36Cl2N6O10S2
Molecular Weight : 871.76


(S)-2-(2-((4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)amino)ethoxy)acetic Acid Hydrochloride
(S)-2-(2-((4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)amino)ethoxy)acetic Acid Hydrochloride
Catalogue No.:PA 18 38820
CAS :
2206135-28-4
Molecular Formula : C14H20ClN3O5
Molecular Weight : 345.78


2,2'-((2R,2'R)-((4-(3-Oxomorpholino)phenyl)azanediyl)bis(2-hydroxypropane-3,1-diyl))bis(isoindoline-1,3-dione)
2,2'-((2R,2'R)-((4-(3-Oxomorpholino)phenyl)azanediyl)bis(2-hydroxypropane-3,1-diyl))bis(isoindoline-1,3-dione)
Catalogue No.:PA 18 38860
CAS :
1643354-27-1
Molecular Formula : C32H30N4O8
Molecular Weight : 598.61


((4-(3-Oxomorpholino)phenyl)azanediyl)bis(1-(1,3-dioxoisoindolin-2-yl)propane-3,2-diyl) bis(1H-imidazole-1-carboxylate)
((4-(3-Oxomorpholino)phenyl)azanediyl)bis(1-(1,3-dioxoisoindolin-2-yl)propane-3,2-diyl) bis(1H-imidazole-1-carboxylate)
Catalogue No.:PA 18 38870
CAS :
NA
Molecular Formula : C40H34N8O10
Molecular Weight : 786.75


4,4'-(((Azanediylbis(2-hydroxypropane-3,1-diyl))bis(azanediyl))bis(4,1-phenylene))bis(morpholin-3-one)
4,4'-(((Azanediylbis(2-hydroxypropane-3,1-diyl))bis(azanediyl))bis(4,1-phenylene))bis(morpholin-3-one)
Catalogue No.:PA 18 38930
CAS :
NA
Molecular Formula : C26H35N5O6
Molecular Weight : 513.6


4-(4-(((3-(5-Chlorothiophene-2-carbonyl)-2-oxooxazolidin-5-yl)methyl)amino)phenyl)morpholin-3-one
4-(4-(((3-(5-Chlorothiophene-2-carbonyl)-2-oxooxazolidin-5-yl)methyl)amino)phenyl)morpholin-3-one
Catalogue No.:PA 18 38940
CAS :
NA
Molecular Formula : C19H18ClN3O5S
Molecular Weight : 435.88


(S)-2,5-Dichloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-3-carboxamide
(S)-2,5-Dichloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-3-carboxamide
Catalogue No.:PA 18 38515
CAS :
NA
Molecular Formula : C19H17Cl2N3O5S
Molecular Weight : 470.32


3-Chloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide
3-Chloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide
Catalogue No.:PA 18 38990
CAS :
1855920-54-5
Molecular Formula : C19H18ClN3O5S
Molecular Weight : 435.88

![2-[[(5R)-2-Oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5 PA 18 38545](https://www.pharmaffiliates.com/pimages/PA1838545.jpg)
2-[[(5R)-2-Oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-1H-isoindole-1,3(2H)-dione
2-[[(5R)-2-Oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-1H-isoindole-1,3(2H)-dione
Catalogue No.:PA 18 38545
CAS :
1424944-35-3
Molecular Formula : C22H19N3O6
Molecular Weight : 421.41


2-(2-((4-((3-(5-Chlorothiophene-2-carboxamido)-2-hydroxypropyl)amino)phenyl)amino)ethoxy)acetic Acid Hydrochloride
2-(2-((4-((3-(5-Chlorothiophene-2-carboxamido)-2-hydroxypropyl)amino)phenyl)amino)ethoxy)acetic Acid Hydrochloride
Catalogue No.:PA 18 0381010
CAS :
NA
Molecular Formula : C18H23Cl2N3O5S
Molecular Weight : 464.36


(S)-2-(2-((4-((3-(5-Chlorothiophene-2-carboxamido)-2-hydroxypropyl)amino)phenyl)amino)ethoxy)acetic Acid
(S)-2-(2-((4-((3-(5-Chlorothiophene-2-carboxamido)-2-hydroxypropyl)amino)phenyl)amino)ethoxy)acetic Acid
Catalogue No.:PA 18 0381013
CAS :
NA
Molecular Formula : C18H22ClN3O5S
Molecular Weight : 427.9

![5-Chloro-N-[[(5S)-3-[4-[(2-hydroxyethyl)amino]phen PA 18 0381014](https://www.pharmaffiliates.com/pimages/PA180381014.jpg)
5-Chloro-N-[[(5S)-3-[4-[(2-hydroxyethyl)amino]phenyl]-2-oxo-5-oxazolidinyl]methyl]-2-thiophenecarboxamide
5-Chloro-N-[[(5S)-3-[4-[(2-hydroxyethyl)amino]phenyl]-2-oxo-5-oxazolidinyl]methyl]-2-thiophenecarboxamide
Catalogue No.:PA 18 0381014
CAS :
936232-22-3
Molecular Formula : C17H18ClN3O4S
Molecular Weight : 395.86


5-Chloro-N-[[(5S)-3-[4-(2-Hydroxy-3-oxo-4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-2-thiophenecarboxamide
5-Chloro-N-[[(5S)-3-[4-(2-Hydroxy-3-oxo-4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-2-thiophenecarboxamide
Catalogue No.:PA 18 0381015
CAS :
1160169-99-2
Molecular Formula : C19H18ClN3O6S
Molecular Weight : 451.88


(S)-(3-(5-Chlorothiophene-2-carboxamido)-2-hydroxypropyl)(4-(3-oxomorpholino)phenyl)carbamic Acid
(S)-(3-(5-Chlorothiophene-2-carboxamido)-2-hydroxypropyl)(4-(3-oxomorpholino)phenyl)carbamic Acid
Catalogue No.:PA 18 0381016
CAS :
2304798-51-2
Molecular Formula : C19H20ClN3O6S
Molecular Weight : 453.89

![2-[[4-[(5S)-5-[[[(5-Chloro-2-thienyl)carbonyl]amin PA 18 0381017](https://www.pharmaffiliates.com/pimages/PA180381017.jpg)
2-[[4-[(5S)-5-[[[(5-Chloro-2-thienyl)carbonyl]amino]methyl]-2-oxo-3-oxazolidinyl]phenyl](2-hydroxyethyl)amino]-2-oxo-acetic Acid
2-[[4-[(5S)-5-[[[(5-Chloro-2-thienyl)carbonyl]amino]methyl]-2-oxo-3-oxazolidinyl]phenyl](2-hydroxyethyl)amino]-2-oxo-acetic Acid
Catalogue No.:PA 18 0381017
CAS :
1160169-98-1
Molecular Formula : C19H18ClN3O7S
Molecular Weight : 467.88


(S)-N-((3-(4-Acetamidophenyl)-2-oxooxazolidin-5-yl)methyl)-5-chlorothiophene-2-carboxamide
(S)-N-((3-(4-Acetamidophenyl)-2-oxooxazolidin-5-yl)methyl)-5-chlorothiophene-2-carboxamide
Catalogue No.:PA 18 0381021
CAS :
2422046-61-3
Molecular Formula : C17H16ClN3O4S
Molecular Weight : 393.84


4-(4-((((S)-2-Oxo-3-(((S)-2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)oxazolidin-5-yl)methyl)amino)phenyl)morpholin-3-one
4-(4-((((S)-2-Oxo-3-(((S)-2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)oxazolidin-5-yl)methyl)amino)phenyl)morpholin-3-one
Catalogue No.:PA 18 0381027
CAS :
NA
Molecular Formula : C28H31N5O8
Molecular Weight : 565.58