roflumilast and its Impurities

Roflumilast is used in the prevention of lung attacks in severe COPD. It is a long-acting inhibitor of the enzyme phosphodiesterase-4 (PDE-4).Reference standards of Roflumilast API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

Displaying 38 results for roflumilast Impurities
Drug Reference Standards & Impurity Synthesis in India
PA 18 15000

Roflumilast

Roflumilast

  • Catalogue No.:PA 18 15000

  • CAS :

    162401-32-3

  • Molecular Formula : C17H14Cl2F2N2O3

  • Molecular Weight : 403.21

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Drug Reference Standards & Impurity Synthesis in India
PA 18 15510

5-Dechloro Roflumilast

5-Dechloro Roflumilast

  • Catalogue No.:PA 18 15510

  • CAS :

    1391053-75-0

  • Molecular Formula : C17H15ClF2N2O3

  • Molecular Weight : 368.76

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Drug Reference Standards & Impurity Synthesis in India
PA 18 15520

3-O-Decyclopropyl Roflumilast

3-O-Decyclopropyl Roflumilast

  • Catalogue No.:PA 18 15520

  • CAS :

    1391052-76-8

  • Molecular Formula : C13H8Cl2F2N2O3

  • Molecular Weight : 349.12

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Drug Reference Standards & Impurity Synthesis in India
PA 18 15530

Roflumilast N-Oxide

Roflumilast N-Oxide

  • Catalogue No.:PA 18 15530

  • CAS :

    292135-78-5

  • Molecular Formula : C17H14Cl2F2N2O4

  • Molecular Weight : 419.21

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Drug Reference Standards & Impurity Synthesis in India
PA 18 15540

Roflumilast Carboxylic Acid Impurity

Roflumilast Carboxylic Acid Impurity

  • Catalogue No.:PA 18 15540

  • CAS :

    162401-62-9

  • Molecular Formula : C12H12F2O4

  • Molecular Weight : 258.22

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Drug Reference Standards & Impurity Synthesis in India
PA 18 15550

4-Amino-3,5-dichloropyridine

4-Amino-3,5-dichloropyridine

  • Catalogue No.:PA 18 15550

  • CAS :

    22889-78-7

  • Molecular Formula : C5H4Cl2N2

  • Molecular Weight : 163

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Drug Reference Standards & Impurity Synthesis in India
PA 18 15560

3-(Cyclobutoxy-N-(3,5-dichloropyridin-4-yl))-4-(difluoromethoxy)benzamide

3-(Cyclobutoxy-N-(3,5-dichloropyridin-4-yl))-4-(difluoromethoxy)benzamide

  • Catalogue No.:PA 18 15560

  • CAS :

    2368178-28-1

  • Molecular Formula : C17H14Cl2F2N2O3

  • Molecular Weight : 403.21

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Drug Reference Standards & Impurity Synthesis in India
PA 18 15570

3,4-Di(cyclopropylmethoxy) Roflumilast

3,4-Di(cyclopropylmethoxy) Roflumilast

  • Catalogue No.:PA 18 15570

  • CAS :

    1391052-24-6

  • Molecular Formula : C20H20Cl2N2O3

  • Molecular Weight : 407.29

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Drug Reference Standards & Impurity Synthesis in India
PA 18 15580

4-(Cyclopropylmethoxy)-3-(difluoromethoxy) Roflumilast

4-(Cyclopropylmethoxy)-3-(difluoromethoxy) Roflumilast

  • Catalogue No.:PA 18 15580

  • CAS :

    162401-43-6

  • Molecular Formula : C17H14Cl2F2N2O3

  • Molecular Weight : 403.21

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Drug Reference Standards & Impurity Synthesis in India
PA 18 15590

3,4-bis(Difluoromethoxy) Roflumilast

3,4-bis(Difluoromethoxy) Roflumilast

  • Catalogue No.:PA 18 15590

  • CAS :

    162401-30-1

  • Molecular Formula : C14H8Cl2F4N2O3

  • Molecular Weight : 399.12

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Drug Reference Standards & Impurity Synthesis in India
PA 18 15600

N-(3,5-Dichloro-4-pyridinyl)-3,4-Dihydroxybenzamide

N-(3,5-Dichloro-4-pyridinyl)-3,4-Dihydroxybenzamide

  • Catalogue No.:PA 18 15600

  • CAS :

    1412448-29-3

  • Molecular Formula : C12H8Cl2N2O3

  • Molecular Weight : 299.11

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Drug Reference Standards & Impurity Synthesis in India
PA 18 15610

3-Cyclobutyl-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide

3-Cyclobutyl-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide

  • Catalogue No.:PA 18 15610

  • CAS :

    NA

  • Molecular Formula : C17H14Cl2F2N2O2

  • Molecular Weight : 387.21

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Drug Reference Standards & Impurity Synthesis in India
PA 18 15620

3-(But-3-en-1-yloxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide

3-(But-3-en-1-yloxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide

  • Catalogue No.:PA 18 15620

  • CAS :

    2368178-29-2

  • Molecular Formula : C17H14Cl2F2N2O3

  • Molecular Weight : 403.21

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Drug Reference Standards & Impurity Synthesis in India
PA 18 15630

3,4-Di(cyclopropylmethoxy)-benzoic Acid

3,4-Di(cyclopropylmethoxy)-benzoic Acid

  • Catalogue No.:PA 18 15630

  • CAS :

    1369851-30-8

  • Molecular Formula : C15H18O4

  • Molecular Weight : 262.3

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Drug Reference Standards & Impurity Synthesis in India
PA 18 15640

4-(Cyclopropylmethoxy)-3-(difluoromethoxy) benzoic Acid

4-(Cyclopropylmethoxy)-3-(difluoromethoxy) benzoic Acid

  • Catalogue No.:PA 18 15640

  • CAS :

    162401-69-6

  • Molecular Formula : C12H12F2O4

  • Molecular Weight : 258.22

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Drug Reference Standards & Impurity Synthesis in India
PA 18 15650

3,4-bis(Difluoromethoxy)benzoic Acid

3,4-bis(Difluoromethoxy)benzoic Acid

  • Catalogue No.:PA 18 15650

  • CAS :

    162401-60-7

  • Molecular Formula : C9H6F4O4

  • Molecular Weight : 254.14

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Drug Reference Standards & Impurity Synthesis in India
PA STI 023650

3-Cyclopropylmethoxy-4-difluoromethoxybenzoic-d4 Acid

3-Cyclopropylmethoxy-4-difluoromethoxybenzoic-d4 Acid

  • Catalogue No.:PA STI 023650

  • CAS :

    1794816-96-8

  • Molecular Formula : C12H8D4F2O4

  • Molecular Weight : 262.24

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Drug Reference Standards & Impurity Synthesis in India
PA STI 078300

Roflumilast-d4

Roflumilast-d4

  • Catalogue No.:PA STI 078300

  • CAS :

    1398065-69-4

  • Molecular Formula : C17H11D3Cl2F2N2O3

  • Molecular Weight : 407.23

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Drug Reference Standards & Impurity Synthesis in India
PA STI 078310

Roflumilast-d4 N-Oxide

Roflumilast-d4 N-Oxide

  • Catalogue No.:PA STI 078310

  • CAS :

    1794760-31-8

  • Molecular Formula : C17H10D4Cl2F2N2O4

  • Molecular Weight : 423.23

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Drug Reference Standards & Impurity Synthesis in India
PA 18 15660

2,5-Dichloropyridin-4-amine

2,5-Dichloropyridin-4-amine

  • Catalogue No.:PA 18 15660

  • CAS :

    405230-82-2

  • Molecular Formula : C5H4Cl2N2

  • Molecular Weight : 163

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Drug Reference Standards & Impurity Synthesis in India
PA 18 15670

2,3-Dichloropyridin-4-amine

2,3-Dichloropyridin-4-amine

  • Catalogue No.:PA 18 15670

  • CAS :

    184416-83-9

  • Molecular Formula : C5H4Cl2N2

  • Molecular Weight : 163

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Drug Reference Standards & Impurity Synthesis in India
PA 18 15680

4-Amino-2,6-dichloropyridine

4-Amino-2,6-dichloropyridine

  • Catalogue No.:PA 18 15680

  • CAS :

    2587-02-2

  • Molecular Formula : C5H4Cl2N2

  • Molecular Weight : 163

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Drug Reference Standards & Impurity Synthesis in India
PA IPIPRS 81 13

Roflumilast (IPRS/81/13)-from IPC

Roflumilast (IPRS/81/13)-from IPC

  • Catalogue No.:PA IPIPRS 81 13

  • CAS :

    NA

  • Molecular Formula : NA

  • Molecular Weight : NA

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Drug Reference Standards & Impurity Synthesis in India
PA 18 0151000

3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-hydroxybenzamide

3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-hydroxybenzamide

  • Catalogue No.:PA 18 0151000

  • CAS :

    475271-62-6

  • Molecular Formula : C16H14Cl2N2O3

  • Molecular Weight : 353.2

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Drug Reference Standards & Impurity Synthesis in India
PA 18 0151001

N-(3-Bromo-5-chloropyridin-4-yl)-3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzamide

N-(3-Bromo-5-chloropyridin-4-yl)-3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzamide

  • Catalogue No.:PA 18 0151001

  • CAS :

    3031785-18-6

  • Molecular Formula : C17H14BrClF2N2O3

  • Molecular Weight : 447.66

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Drug Reference Standards & Impurity Synthesis in India
PA 18 0151002

5-((3,5-Dichloropyridin-4-yl)carbamoyl)-2-(difluoromethoxy)phenyl dimethylcarbamate

5-((3,5-Dichloropyridin-4-yl)carbamoyl)-2-(difluoromethoxy)phenyl dimethylcarbamate

  • Catalogue No.:PA 18 0151002

  • CAS :

    2048860-65-5

  • Molecular Formula : C16H13Cl2F2N3O4

  • Molecular Weight : 420.19

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Drug Reference Standards & Impurity Synthesis in India
PA 18 0151003

 4-(Difluoromethoxy)-3-Hydroxybenzoic Acid

4-(Difluoromethoxy)-3-Hydroxybenzoic Acid

  • Catalogue No.:PA 18 0151003

  • CAS :

    913985-07-6

  • Molecular Formula : C8H6F2O4

  • Molecular Weight : 204.13

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Drug Reference Standards & Impurity Synthesis in India
PA 18 0151004

Roflumilast KSM-II Bromo Compound

Roflumilast KSM-II Bromo Compound

  • Catalogue No.:PA 18 0151004

  • CAS :

    159783-78-5

  • Molecular Formula : C5H4BrClN2

  • Molecular Weight : 207.46

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Drug Reference Standards & Impurity Synthesis in India
PA 18 0151005

Roflumilast Dimer

Roflumilast Dimer

  • Catalogue No.:PA 18 0151005

  • CAS :

    1352122-37-2

  • Molecular Formula : C29H24Cl2F4N2O6

  • Molecular Weight : 643.41

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Drug Reference Standards & Impurity Synthesis in India
PA 18 0151006

3-(Cyclopropylmethoxy)-4-hydroxybenzaldehyde

3-(Cyclopropylmethoxy)-4-hydroxybenzaldehyde

  • Catalogue No.:PA 18 0151006

  • CAS :

    25934-52-5

  • Molecular Formula : C11H12O3

  • Molecular Weight : 192.21

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Drug Reference Standards & Impurity Synthesis in India
PA 18 0151007

3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde

3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde

  • Catalogue No.:PA 18 0151007

  • CAS :

    151103-09-2

  • Molecular Formula : C12H12F2O3

  • Molecular Weight : 242.22

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Drug Reference Standards & Impurity Synthesis in India
PA 18 0151008

3-(Cyclopropylmethoxy)-4-hydroxybenzoic Acid

3-(Cyclopropylmethoxy)-4-hydroxybenzoic Acid

  • Catalogue No.:PA 18 0151008

  • CAS :

    1243391-44-7

  • Molecular Formula : C11H12O4

  • Molecular Weight : 208.21

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Drug Reference Standards & Impurity Synthesis in India
PA 18 0151009

N-(3,5-Dichloropyridin-4-yl)-4-(difluoromethoxy)-3-methoxybenzamide

N-(3,5-Dichloropyridin-4-yl)-4-(difluoromethoxy)-3-methoxybenzamide

  • Catalogue No.:PA 18 0151009

  • CAS :

    162401-29-8

  • Molecular Formula : C14H10Cl2F2N2O3

  • Molecular Weight : 363.14

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Drug Reference Standards & Impurity Synthesis in India
PA IPRSR033

Roflumilast (IPRSR033)

Roflumilast (IPRSR033)

  • Catalogue No.:PA IPRSR033

  • CAS :

    NA

  • Molecular Formula : NA

  • Molecular Weight : NA

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Drug Reference Standards & Impurity Synthesis in India
PA 18 0151010

3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-N-methylbenzamide

3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-N-methylbenzamide

  • Catalogue No.:PA 18 0151010

  • CAS :

    1616666-83-1

  • Molecular Formula : C18H16Cl2F2N2O3

  • Molecular Weight : 417.23

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Drug Reference Standards & Impurity Synthesis in India
PA 18 0151011

Roflumilast Cyclized Impurity

Roflumilast Cyclized Impurity

  • Catalogue No.:PA 18 0151011

  • CAS :

    2206607-17-0

  • Molecular Formula : C17H13ClF2N2O3

  • Molecular Weight : 366.75

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Drug Reference Standards & Impurity Synthesis in India
PA 18 0151012

(E)-1,2-Bis(3-chloropyridin-4-yl)diazene

(E)-1,2-Bis(3-chloropyridin-4-yl)diazene

  • Catalogue No.:PA 18 0151012

  • CAS :

    2407572-31-8

  • Molecular Formula : C10H6Cl2N4

  • Molecular Weight : 253.09

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Drug Reference Standards & Impurity Synthesis in India
PA 18 0151013

(E)-1,2-Di(pyridin-4-yl)diazene

(E)-1,2-Di(pyridin-4-yl)diazene

  • Catalogue No.:PA 18 0151013

  • CAS :

    4253-82-1

  • Molecular Formula : C10H8N4

  • Molecular Weight : 184.2

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