sacubitril and its Impurities
An antihypertensive drug, Sacubitril is used in combination with valsartan for the treatment of heart ailments. A prodrug of sacubitrilat which is an inhibitor of enzyme neprilysin, which aids the degradation of blood pressure-lowering peptides, atrial and brain natriuretic peptide.Reference standards of Sacubitril API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


(2R,4S)-2-Methyl-4-[(2-methylpropan-2-yl)oxycarbonylamino]-5-(4-phenylphenyl)pentanoic Acid
(2R,4S)-2-Methyl-4-[(2-methylpropan-2-yl)oxycarbonylamino]-5-(4-phenylphenyl)pentanoic Acid
Catalogue No.:PA 19 66520
CAS :
1012341-50-2
Molecular Formula : C23H29NO4
Molecular Weight : 383.48


(αR,γR)-γ-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-methyl-[1,1'-biphenyl]-4-pentanoic Acid
(αR,γR)-γ-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-methyl-[1,1'-biphenyl]-4-pentanoic Acid
Catalogue No.:PA 19 66550
CAS :
1012341-56-8
Molecular Formula : C23H29NO4
Molecular Weight : 383.48

![4-(((2S,4R)-1-([1,1'-Biphenyl]-4-yl)-5-methoxy-4-m PA 19 66730](https://www.pharmaffiliates.com/pimages/PA1966730.jpg)
4-(((2S,4R)-1-([1,1'-Biphenyl]-4-yl)-5-methoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic Acid
4-(((2S,4R)-1-([1,1'-Biphenyl]-4-yl)-5-methoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic Acid
Catalogue No.:PA 19 66730
CAS :
2408053-56-3
Molecular Formula : C23H27NO5
Molecular Weight : 397.47

![4-(((2S,4R)-1-([1,1'-Biphenyl]-4-yl)-4-methyl-5-ox PA 19 66740](https://www.pharmaffiliates.com/pimages/PA1966740.jpg)
4-(((2S,4R)-1-([1,1'-Biphenyl]-4-yl)-4-methyl-5-oxo-5-propoxypentan-2-yl)amino)-4-oxobutanoic Acid
4-(((2S,4R)-1-([1,1'-Biphenyl]-4-yl)-4-methyl-5-oxo-5-propoxypentan-2-yl)amino)-4-oxobutanoic Acid
Catalogue No.:PA 19 66740
CAS :
2751722-76-4
Molecular Formula : C25H31NO5
Molecular Weight : 425.53

![(2E,4S)-5-[1,1'-Biphenyl]-4-yl-4-[[(1,1-dimethylet PA 19 0661010](https://www.pharmaffiliates.com/pimages/PA190661010.jpg)
(2E,4S)-5-[1,1'-Biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-2-pentenoic Acid
(2E,4S)-5-[1,1'-Biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-2-pentenoic Acid
Catalogue No.:PA 19 0661010
CAS :
1015037-46-3
Molecular Formula : C23H27NO4
Molecular Weight : 381.47

![(2R,4S)-Isopropyl 5-([1,1'-biphenyl]-4-yl)-4-(4-is PA 19 0661012](https://www.pharmaffiliates.com/pimages/PA190661012.jpg)
(2R,4S)-Isopropyl 5-([1,1'-biphenyl]-4-yl)-4-(4-isopropoxy-4-oxobutanamido)-2-methylpentanoate
(2R,4S)-Isopropyl 5-([1,1'-biphenyl]-4-yl)-4-(4-isopropoxy-4-oxobutanamido)-2-methylpentanoate
Catalogue No.:PA 19 0661012
CAS :
2216755-67-6
Molecular Formula : C28H37NO5
Molecular Weight : 467.61

![Ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-(4-isopro PA 19 0661013](https://www.pharmaffiliates.com/pimages/PA190661013.jpg)
Ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-(4-isopropoxy-4-oxobutanamido)-2-methylpentanoate
Ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-(4-isopropoxy-4-oxobutanamido)-2-methylpentanoate
Catalogue No.:PA 19 0661013
CAS :
2459446-53-6
Molecular Formula : C27H35NO5
Molecular Weight : 453.58

![Isopropyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-(2,5- PA 19 0661015](https://www.pharmaffiliates.com/pimages/PA190661015.jpg)
Isopropyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-(2,5-dioxopyrrolidin-1-yl)-2-methylpentanoate
Isopropyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-(2,5-dioxopyrrolidin-1-yl)-2-methylpentanoate
Catalogue No.:PA 19 0661015
CAS :
2459446-55-8
Molecular Formula : C25H29NO4
Molecular Weight : 407.51

![Isopropyl 4-((3R,5S)-5-([1,1'-biphenyl]-4-ylmethyl PA 19 0661018](https://www.pharmaffiliates.com/pimages/PA190661018.jpg)
Isopropyl 4-((3R,5S)-5-([1,1'-biphenyl]-4-ylmethyl)-3-methyl-2-oxopyrrolidin-1-yl)-4-oxobutanoate
Isopropyl 4-((3R,5S)-5-([1,1'-biphenyl]-4-ylmethyl)-3-methyl-2-oxopyrrolidin-1-yl)-4-oxobutanoate
Catalogue No.:PA 19 0661018
CAS :
2149600-13-3
Molecular Formula : C25H29NO4
Molecular Weight : 407.51

![4-(((2S,4R)-1-([1,1'-Biphenyl]-4-yl)-5-isopropoxy- PA 19 0661020](https://www.pharmaffiliates.com/pimages/PA190661020.jpg)
4-(((2S,4R)-1-([1,1'-Biphenyl]-4-yl)-5-isopropoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid
4-(((2S,4R)-1-([1,1'-Biphenyl]-4-yl)-5-isopropoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid
Catalogue No.:PA 19 0661020
CAS :
2514965-95-6
Molecular Formula : C25H31NO5
Molecular Weight : 425.53


(E)-(R)-5-Biphenyl-4-yl-4-(3-carboxy-propionylamino)-2-methyl-pent-2-enoic Acid Ethyl Ester
(E)-(R)-5-Biphenyl-4-yl-4-(3-carboxy-propionylamino)-2-methyl-pent-2-enoic Acid Ethyl Ester
Catalogue No.:PA 19 0661023
CAS :
2957885-24-2
Molecular Formula : C24H27NO5
Molecular Weight : 409.48


2-Methylpropan-2-aminium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-methoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
2-Methylpropan-2-aminium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-methoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
Catalogue No.:PA 19 0661025
CAS :
NA
Molecular Formula : C27H38N2O5
Molecular Weight : 470.61


2-Methylpropan-2-aminium (Z)-4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobut-2-enoate
2-Methylpropan-2-aminium (Z)-4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobut-2-enoate
Catalogue No.:PA 19 0661026
CAS :
NA
Molecular Formula : C28H38N2O5
Molecular Weight : 482.62


2-Methylpropan-2-aminium 4-(((2S,4S)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
2-Methylpropan-2-aminium 4-(((2S,4S)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
Catalogue No.:PA 19 0661027
CAS :
NA
Molecular Formula : C28H40N2O5
Molecular Weight : 484.64


2-Methylpropan-2-aminium 4-(((2R,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
2-Methylpropan-2-aminium 4-(((2R,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
Catalogue No.:PA 19 0661028
CAS :
NA
Molecular Formula : C28H40N2O5
Molecular Weight : 484.64

![rel.4-(((2R,4R)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy- PA 19 0661034](https://www.pharmaffiliates.com/pimages/PA190661034.jpg)
rel.4-(((2R,4R)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic Acid
rel.4-(((2R,4R)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic Acid
Catalogue No.:PA 19 0661034
CAS :
766480-48-2
Molecular Formula : C24H29NO5
Molecular Weight : 411.5

![(2Z,4R)-5-[1,1′-Biphenyl]-4-yl-4-[[(1,1-dimethyl PA 19 0661045](https://www.pharmaffiliates.com/pimages/PA190661045.jpg)
(2Z,4R)-5-[1,1′-Biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-2-pentenoic Acid
(2Z,4R)-5-[1,1′-Biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-2-pentenoic Acid
Catalogue No.:PA 19 0661045
CAS :
1361408-16-3
Molecular Formula : C23H27NO4
Molecular Weight : 381.47

![Calcium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-met PA 19 0661058](https://www.pharmaffiliates.com/pimages/PA190661058.jpg)
Calcium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-methoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
Calcium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-methoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
Catalogue No.:PA 19 0661058
CAS :
2751722-74-2
Molecular Formula : C46H54CaN2O10
Molecular Weight : 835.02


2-Methylpropan-2-aminium 4-(((2R,4S)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
2-Methylpropan-2-aminium 4-(((2R,4S)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
Catalogue No.:PA 19 0661061
CAS :
NA
Molecular Formula : C28H40N2O5
Molecular Weight : 484.64

![(2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxyca PA 19 0661063](https://www.pharmaffiliates.com/pimages/PA190661063.jpg)
(2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)(nitroso)amino)-2-methylpentanoic Acid
(2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)(nitroso)amino)-2-methylpentanoic Acid
Catalogue No.:PA 19 0661063
CAS :
NA
Molecular Formula : C23H28N2O5
Molecular Weight : 412.49