Sacubitril Tetrabutylammonium and its Impurities

Sacubitril Tetrabutylammonium, sold under the brand name Entresto, is a fixed-dose combination medication for use in heart failure. It consists of the neprilysin inhibitor sacubitril and the angiotensin receptor blocker valsartan. Reference standards of Sacubitril Tetrabutylammonium API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.