salmeterol and its Impurities
Salmeterol is used for the treatment of moderate-to-severe persistent asthma. It is a long-acting β2 adrenergic receptor agonist (LABA) that acts as a bronchodilator. Salmeterol was first marketed and manufactured by Glaxo.Reference standards of Salmeterol API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
 
	
			                                   
																				Salmeterol - Impurity G
1-[4-Hydroxy-3-[[[2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl][6-(4-phenylbutoxy)hexyl]amino]methyl]phenyl]-2-[[6-(4-phenylbutoxy)hexyl]amino]ethanol.
- Catalogue No.:PA 19 38070 
- CAS : - 2470130-36-8
- Molecular Formula : C50H72N2O7 
- Molecular Weight : 813.12 
 
	
			                                  ![1-(RS)-1-[4-Hydroxy-3-(Hydroxymethylphenyl]-2-[(4- PA STI 049300](https://www.pharmaffiliates.com/pimages/PASTI049300.jpg) 
																				1-(RS)-1-[4-Hydroxy-3-(Hydroxymethylphenyl]-2-[(4-phenylbutyl)aminoethanol-d3 (Salmeterol EP Impurity)
1-(RS)-1-[4-Hydroxy-3-(Hydroxymethylphenyl]-2-[(4-phenylbutyl)aminoethanol-d3 (Salmeterol EP Impurity)
- Catalogue No.:PA STI 049300 
- CAS : - NA
- Molecular Formula : C19H22D3NO3 
- Molecular Weight : 318.43 
 
	
			                                   
																				Salmeterol Related Compound A (4-[1-Hydroxy-2-(4-phenylbutylamino)ethyl]-2-(hydroxymethyl)phenol) (1609614)
Salmeterol Related Compound A (4-[1-Hydroxy-2-(4-phenylbutylamino)ethyl]-2-(hydroxymethyl)phenol) (1609614)
- Catalogue No.:PA USP1609614 
- CAS : - 1798014-51-3
- Molecular Formula : NA 
- Molecular Weight : NA 
 
	
			                                   
																				Salmeterol Related Compound B (3 x 1.3 mg) (4-{1-Hydroxy-2-[6-(4-phenylbutan-2-yloxy)hexylamino]ethy (1609625)
Salmeterol Related Compound B (3 x 1.3 mg) (4-{1-Hydroxy-2-[6-(4-phenylbutan-2-yloxy)hexylamino]ethy (1609625)
- Catalogue No.:PA USP1609625 
- CAS : - 108928-81-0
- Molecular Formula : NA 
- Molecular Weight : NA 
 
	
			                                   
																				Salmeterol Related Compound H (1-hydroxy-4-[2-hydroxy-5-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amin (1609680)
Salmeterol Related Compound H (1-hydroxy-4-[2-hydroxy-5-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amin (1609680)
- Catalogue No.:PA USP1609680 
- CAS : - 1330076-52-2
- Molecular Formula : NA 
- Molecular Weight : NA 
 
	
			                                   
																				2-(Benzyl(6-(4-phenylbutoxy)hexyl)amino)-1-(4-(benzyloxy)-3-(hydroxymethyl)phenyl)ethan-1-ol
2-(Benzyl(6-(4-phenylbutoxy)hexyl)amino)-1-(4-(benzyloxy)-3-(hydroxymethyl)phenyl)ethan-1-ol
- Catalogue No.:PA 19 0381004 
- CAS : - 943969-38-8
- Molecular Formula : C39H49NO4 
- Molecular Weight : 595.82 
 
	
			                                   
																				4-(1-Hydroxy-2-((2-hydroxy-4-(1-hydroxy-2-((6-(4-phenylbutoxy)hexyl)amino)ethyl)benzyl)(6-(4-phenylbutoxy)hexyl)amino)ethyl)-2-(hydroxymethyl)phenol
4-(1-Hydroxy-2-((2-hydroxy-4-(1-hydroxy-2-((6-(4-phenylbutoxy)hexyl)amino)ethyl)benzyl)(6-(4-phenylbutoxy)hexyl)amino)ethyl)-2-(hydroxymethyl)phenol
- Catalogue No.:PA 19 0381006 
- CAS : - 1391051-88-9
- Molecular Formula : C50H72N2O7 
- Molecular Weight : 813.13 
 
	
			                                   
																				N-(2-Hydroxy-2-(4-hydroxy-3-(hydroxymethyl)phenyl)ethyl)-N-(6-(4-phenylbutoxy)hexyl)nitrous Amide
N-(2-Hydroxy-2-(4-hydroxy-3-(hydroxymethyl)phenyl)ethyl)-N-(6-(4-phenylbutoxy)hexyl)nitrous Amide
- Catalogue No.:PA 19 0381008 
- CAS : - 3036581-81-1
- Molecular Formula : C25H36N2O5 
- Molecular Weight : 444.57 
 
	
			                                   
																				2-(Benzyl(6-(4-(2-bromophenyl)butoxy)hexyl)amino)-1-(4-(benzyloxy)-3-(hydroxymethyl)phenyl)ethan-1-ol
2-(Benzyl(6-(4-(2-bromophenyl)butoxy)hexyl)amino)-1-(4-(benzyloxy)-3-(hydroxymethyl)phenyl)ethan-1-ol
- Catalogue No.:PA 19 0381012 
- CAS : - NA
- Molecular Formula : C39H48BrNO4 
- Molecular Weight : 674.72 
 
	
			                                   
																				2-(Benzyl(6-(4-(4-bromophenyl)butoxy)hexyl)amino)-1-(4-(benzyloxy)-3-(hydroxymethyl)phenyl)ethan-1-ol
2-(Benzyl(6-(4-(4-bromophenyl)butoxy)hexyl)amino)-1-(4-(benzyloxy)-3-(hydroxymethyl)phenyl)ethan-1-ol
- Catalogue No.:PA 19 0381013 
- CAS : - NA
- Molecular Formula : C39H48BrNO4 
- Molecular Weight : 674.72 

 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				![4-Hydroxy-α1-[[[6-(2-phenylethoxy)hexyl]amino]met PA STI 050650](https://www.pharmaffiliates.com/pimages/PASTI050650.jpg) 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				 
																				![[6-(4-Phenylbutoxy)hexyl]benzylamine PA 19 0381000](https://www.pharmaffiliates.com/pimages/PA190381000.jpg) 
																				 
																				 
																				 
																				 
																				 
																				![Tert-Butyl (S)-(2-(2,2-dimethyl-4H-benzo[d][1,3]di PA 19 0381007](https://www.pharmaffiliates.com/pimages/PA190381007.jpg) 
																				 
																				 
																				 
																				 
																				 
 
 
 
