salmeterol and its Impurities
Salmeterol is used for the treatment of moderate-to-severe persistent asthma. It is a long-acting β2 adrenergic receptor agonist (LABA) that acts as a bronchodilator. Salmeterol was first marketed and manufactured by Glaxo.Reference standards of Salmeterol API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


Salmeterol - Impurity G
1-[4-Hydroxy-3-[[[2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl][6-(4-phenylbutoxy)hexyl]amino]methyl]phenyl]-2-[[6-(4-phenylbutoxy)hexyl]amino]ethanol.
Catalogue No.:PA 19 38070
CAS :
2470130-36-8
Molecular Formula : C50H72N2O7
Molecular Weight : 813.12

![1-(RS)-1-[4-Hydroxy-3-(Hydroxymethylphenyl]-2-[(4- PA STI 049300](https://www.pharmaffiliates.com/pimages/PASTI049300.jpg)
1-(RS)-1-[4-Hydroxy-3-(Hydroxymethylphenyl]-2-[(4-phenylbutyl)aminoethanol-d3 (Salmeterol EP Impurity)
1-(RS)-1-[4-Hydroxy-3-(Hydroxymethylphenyl]-2-[(4-phenylbutyl)aminoethanol-d3 (Salmeterol EP Impurity)
Catalogue No.:PA STI 049300
CAS :
NA
Molecular Formula : C19H22D3NO3
Molecular Weight : 318.43


Salmeterol Related Compound A (4-[1-Hydroxy-2-(4-phenylbutylamino)ethyl]-2-(hydroxymethyl)phenol) (1609614)
Salmeterol Related Compound A (4-[1-Hydroxy-2-(4-phenylbutylamino)ethyl]-2-(hydroxymethyl)phenol) (1609614)
Catalogue No.:PA USP1609614
CAS :
1798014-51-3
Molecular Formula : NA
Molecular Weight : NA


Salmeterol Related Compound B (3 x 1.3 mg) (4-{1-Hydroxy-2-[6-(4-phenylbutan-2-yloxy)hexylamino]ethy (1609625)
Salmeterol Related Compound B (3 x 1.3 mg) (4-{1-Hydroxy-2-[6-(4-phenylbutan-2-yloxy)hexylamino]ethy (1609625)
Catalogue No.:PA USP1609625
CAS :
108928-81-0
Molecular Formula : NA
Molecular Weight : NA


Salmeterol Related Compound H (1-hydroxy-4-[2-hydroxy-5-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amin (1609680)
Salmeterol Related Compound H (1-hydroxy-4-[2-hydroxy-5-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amin (1609680)
Catalogue No.:PA USP1609680
CAS :
1330076-52-2
Molecular Formula : NA
Molecular Weight : NA


2-(Benzyl(6-(4-phenylbutoxy)hexyl)amino)-1-(4-(benzyloxy)-3-(hydroxymethyl)phenyl)ethan-1-ol
2-(Benzyl(6-(4-phenylbutoxy)hexyl)amino)-1-(4-(benzyloxy)-3-(hydroxymethyl)phenyl)ethan-1-ol
Catalogue No.:PA 19 0381004
CAS :
943969-38-8
Molecular Formula : C39H49NO4
Molecular Weight : 595.82


4-(1-Hydroxy-2-((2-hydroxy-4-(1-hydroxy-2-((6-(4-phenylbutoxy)hexyl)amino)ethyl)benzyl)(6-(4-phenylbutoxy)hexyl)amino)ethyl)-2-(hydroxymethyl)phenol
4-(1-Hydroxy-2-((2-hydroxy-4-(1-hydroxy-2-((6-(4-phenylbutoxy)hexyl)amino)ethyl)benzyl)(6-(4-phenylbutoxy)hexyl)amino)ethyl)-2-(hydroxymethyl)phenol
Catalogue No.:PA 19 0381006
CAS :
1391051-88-9
Molecular Formula : C50H72N2O7
Molecular Weight : 813.13


N-(2-Hydroxy-2-(4-hydroxy-3-(hydroxymethyl)phenyl)ethyl)-N-(6-(4-phenylbutoxy)hexyl)nitrous Amide
N-(2-Hydroxy-2-(4-hydroxy-3-(hydroxymethyl)phenyl)ethyl)-N-(6-(4-phenylbutoxy)hexyl)nitrous Amide
Catalogue No.:PA 19 0381008
CAS :
3036581-81-1
Molecular Formula : C25H36N2O5
Molecular Weight : 444.57